Protease inhibitors and their peptidomimetic derivatives as potential drugs (Q36650691)

15 August 2017

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title

Protease inhibitors and their peptidomimetic derivatives as potential drugs (English)

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15 August 2017

Slavko Komarnytsky

2

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author name string

Georgie Fear

series ordinal

1

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15 August 2017

Ilya Raskin

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3

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15 August 2017

language of work or name

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22 September 2006

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Pharmacology & Therapeutics

15 August 2017

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15 August 2017

113

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15 August 2017

2

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15 August 2017

354-368

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Doxycycline and tissue repair in rats

15 August 2017

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12 December 2020

Unraveling the role of proteases in cancer

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12 December 2020

Marked inhibition of tumor growth in a malignant glioma tumor model by a novel synthetic matrix metalloproteinase inhibitor AG3340.

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12 December 2020

Treatment with an oral proteinase inhibitor slows gastric emptying and acutely reduces glucose and insulin levels after a liquid meal in type II diabetic patients

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12 December 2020

Novel roles of protease inhibitors in infection and inflammation

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12 December 2020

Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers

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12 December 2020

A novel coronavirus associated with severe acute respiratory syndrome

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12 December 2020

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

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12 December 2020

Design of selective eglin inhibitors of HCV NS3 proteinase

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12 December 2020

Clinical modulation of oral leukoplakia and protease activity by Bowman-Birk inhibitor concentrate in a phase IIa chemoprevention trial

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12 December 2020

Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors

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12 December 2020

Oral trypsin inhibitor can improve reflux esophagitis after distal gastrectomy concomitant with decreased trypsin activity

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12 December 2020

Soybean trypsin inhibitor confers protection against rotavirus infection in infant mice

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12 December 2020

Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke.

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12 December 2020

Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes.

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12 December 2020

Inhibitors of the proteolytic activity of urokinase type plasminogen activator

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12 December 2020

Reducing bleeding complications after thrombolytic therapy for stroke: clinical potential of metalloproteinase inhibitors and spin trap agents

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12 December 2020

Nanomolar concentrations of Bowman-Birk soybean protease inhibitor suppress x-ray-induced transformation in vitro

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12 December 2020

The interaction of the potato-derived chymotrypsin inhibitor with C3H/10T1/2 cells.

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12 December 2020

Proteasome inhibitor bortezomib for the treatment of multiple myeloma.

1 reference

12 December 2020

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

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12 December 2020

Quest for selectivity in inhibition of matrix metalloproteinases

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12 December 2020

Bowman-Birk inhibitor abates proteasome function and suppresses the proliferation of MCF7 breast cancer cells through accumulation of MAP kinase phosphatase-1.

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12 December 2020

Impact of protease inhibitors and other antiretroviral treatments on acquired immunodeficiency syndrome survival in San Francisco, California, 1987-1996.

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12 December 2020

Liquid chromatography-mass spectrometry and liquid chromatography-NMR characterization of in vitro metabolites of a potent and irreversible peptidomimetic inhibitor of rhinovirus 3C protease

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12 December 2020

Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA.

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12 December 2020

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

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12 December 2020

Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells

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12 December 2020

Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata

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12 December 2020

Phase I trial of the matrix metalloproteinase inhibitor BAY12-9566 in patients with advanced solid tumors

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12 December 2020

Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy.

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12 December 2020

Aprotinin diminishes inflammatory processes

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12 December 2020

In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease

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12 December 2020

Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid

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12 December 2020

Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4)

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12 December 2020

Bivalirudin: a direct thrombin inhibitor

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12 December 2020

Non-peptide inhibitors of HCV serine proteinase

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12 December 2020

RAS inhibition in hypertension

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12 December 2020

Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis.

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12 December 2020

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

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12 December 2020

Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis

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12 December 2020

Antimalarial synergy of cysteine and aspartic protease inhibitors

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12 December 2020

Treatment of acute pancreatitis with protease inhibitors: a meta-analysis

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12 December 2020

Alpha 1-antitrypsin Pittsburgh (Met358-->Arg) inhibits the contact pathway of intrinsic coagulation and alters the release of human neutrophil elastase during simulated extracorporeal circulation

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12 December 2020

The uPA/uPA receptor system as a target for tumor therapy.

1 reference

12 December 2020

N-arylaminonitriles as bioavailable peptidomimetic inhibitors of cathepsin B

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12 December 2020

Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

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12 December 2020

ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms

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12 December 2020

Selective kallikrein inhibitors alter human neutrophil elastase release during extracorporeal circulation

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12 December 2020

Battle against malaria could involve anti-HIV drugs.

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12 December 2020

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

1 reference

12 December 2020

Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies

1 reference

12 December 2020

Cysteine proteases of malaria parasites

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12 December 2020

Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease

1 reference

12 December 2020

Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B

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12 December 2020

Proteases and the diabetic foot syndrome: mechanisms and therapeutic implications

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12 December 2020

Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors

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12 December 2020

Pharmacokinetics and safety of an antirhinoviral agent, ruprintrivir, in healthy volunteers

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12 December 2020

Protease Inhibitors Prevent the Development of Human Rotavirus-Induced Diarrhea in Suckling Mice

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12 December 2020

SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells

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12 December 2020

Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L.

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12 December 2020

Treatment of SARS with human interferons

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12 December 2020

Matrix metalloproteinases: structures, evolution, and diversification

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12 December 2020

Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings.

1 reference

12 December 2020

Inhibition of human rhinovirus-induced cytokine production by AG7088, a human rhinovirus 3C protease inhibitor

1 reference

12 December 2020

Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat

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12 December 2020

Cholecystokinin and satiety: current perspectives

1 reference

12 December 2020

Pyrimido[1,2- b ]-1,2,4,5-tetrazin-6-ones as HCMV protease inhibitors: a new class of heterocycles with flavin-like redox properties

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12 December 2020

Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors.

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12 December 2020

Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies

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12 December 2020

Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors

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12 December 2020

Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells

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12 December 2020

Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro.

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12 December 2020

Inhalation of alpha(1)-protease inhibitor in cystic fibrosis does not affect surfactant convertase and surface activity

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12 December 2020

Oral administration of proteinase inhibitor II from potatoes reduces energy intake in man.

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12 December 2020

The nutritive quality and the trypsin inhibitor content of soybean flour heated at various temperatures

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12 December 2020

Peptidomimetic inhibitors of the human cytomegalovirus protease.

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12 December 2020

In vitro antiviral activity and single-dose pharmacokinetics in humans of a novel, orally bioavailable inhibitor of human rhinovirus 3C protease

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12 December 2020

Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor cell growth

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12 December 2020

Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril

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12 December 2020

Regulation of pulmonary and systemic bacterial lipopolysaccharide responses in transgenic mice expressing human elafin

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12 December 2020

Picornavirus receptor down-regulation by plasminogen activator inhibitor type 2

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12 December 2020

Membrane associated proteases and their inhibitors in tumour angiogenesis

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12 December 2020

Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo

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12 December 2020

Attenuation of host defense function of lung phagocytes in young cystic fibrosis patients

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12 December 2020

Procyanidin structure defines the extent and specificity of angiotensin I converting enzyme inhibition

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12 December 2020

Evolutionary families of peptidase inhibitors

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12 December 2020

Consumption of diets containing raw soya beans (Glycine max), kidney beans (Phaseolus vulgaris), cowpeas (Vigna unguiculata) or lupin seeds (Lupinus angustifolius) by rats for up to 700 days: effects on body composition and organ weights

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12 December 2020

Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors

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12 December 2020

Extracellular proteases as targets for treatment of cancer metastases

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12 December 2020

Longitudinal follow-up of patients with alpha(1)-protease inhibitor deficiency before and during therapy with IV alpha(1)-protease inhibitor

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12 December 2020

New mechanism-based inactivators of trypsin-like proteinases. Selective inactivation of urokinase by functionalized cyclopeptides incorporating a sulfoniomethyl-substituted m-aminobenzoic acid residue.

1 reference

12 December 2020

In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses

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12 December 2020

HIV protease inhibitors and atherosclerosis

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12 December 2020

The role of protease inhibition with emphasis on the effects of inflammation and vascular immune phenomena

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12 December 2020

Trypsin activation pathway of rotavirus infectivity.

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12 December 2020

Leucaena leucocephala serine proteinase inhibitor: primary structure and action on blood coagulation, kinin release and rat paw edema

1 reference

12 December 2020

Inhibition of urokinase by 4-substituted benzo[b]thiophene-2-carboxamidines: an important new class of selective synthetic urokinase inhibitor

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12 December 2020

Selective nonpeptidic inhibitors of herpes simplex virus type 1 and human cytomegalovirus proteases

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12 December 2020

Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury

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12 December 2020

Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain

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12 December 2020

Novel hepatitis C virus protease inhibitors: thiazolidine derivatives

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12 December 2020

Plasmepsins as potential targets for new antimalarial therapy

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12 December 2020

Inhibitors of proteases as anticancer drugs.

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12 December 2020

HIV protease inhibitors attenuate adherence of Candida albicans to epithelial cells in vitro

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12 December 2020

The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications

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12 December 2020

Gateways to clinical trials

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12 December 2020

Oral anticoagulants in development: focus on thromboprophylaxis in patients undergoing orthopaedic surgery

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12 December 2020

Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents

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12 December 2020

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

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12 December 2020

Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus

1 reference

12 December 2020

Lopinavir/ritonavir as single-drug therapy for maintenance of HIV-1 viral suppression: 48-week results of a randomized, controlled, open-label, proof-of-concept pilot clinical trial (OK Study).

1 reference

12 December 2020

Proteinase inhibitors I and II from potatoes block UVB-induced AP-1 activity by regulating the AP-1 protein compositional patterns in JB6 cells

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12 December 2020

Crystal structure of Dengue virus NS3 protease in complex with a Bowman-Birk inhibitor: implications for flaviviral polyprotein processing and drug design

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12 December 2020

Cysteine protease inhibitors as chemotherapy: lessons from a parasite target

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12 December 2020

Serine protease inhibitors block invasion of host cells by Toxoplasma gondii.

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12 December 2020

Structure-based design of aliskiren, a novel orally effective renin inhibitor

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12 December 2020

Proteinase inhibitors induce selective stimulation of human trypsin and chymotrypsin secretion

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12 December 2020

Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients.

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12 December 2020

Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits

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12 December 2020

Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C.

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12 December 2020

Metalloproteinases, inflammation, and rheumatoid arthritis.

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12 December 2020

Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight.

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12 December 2020

Protease inhibitors as antiviral agents.

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12 December 2020

Aprotinin improves kidney function and decreases tubular cell apoptosis and proapoptotic signaling after renal ischemia-reperfusion

1 reference

12 December 2020

Expression and functional properties of antibodies to tissue inhibitors of metalloproteinases (TIMPs) in rheumatoid arthritis

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12 December 2020

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12 December 2020

Aprotinin attenuated ischemia-reperfusion injury in an isolated rat lung model after 18-hours preservation

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12 December 2020

Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents?

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12 December 2020

Flavins inhibit human cytomegalovirus UL80 protease via disulfide bond formation

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12 December 2020

Effects of the Bowman-Birk inhibitor on growth, invasion, and clonogenic survival of human prostate epithelial cells and prostate cancer cells

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12 December 2020

Apical cell surface expression of rat dipeptidyl peptidase IV in transfected Madin-Darby canine kidney cells

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12 December 2020

Anti-inflammatory effects of mutant forms of secretory leukocyte protease inhibitor

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12 December 2020

Acceleration of phagocytosis in human neutrophils incubated with gabexate mesilate

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12 December 2020

HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus

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12 December 2020

Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.

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12 December 2020

Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases.

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12 December 2020

Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro

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12 December 2020

Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.

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12 December 2020

Tactics for vascular protection after acute ischemic stroke

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12 December 2020

Design and therapeutic application of matrix metalloproteinase inhibitors

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12 December 2020

10.1016/J.PHARMTHERA.2006.09.001

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DOI

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release_7fnx3ypxbzb2fe4h7xlizqkmte

15 August 2017

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