Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice (Q34090139)

30 July 2017

Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice (English)

1 reference

30 July 2017

Sam D Molyneux

1

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Tamara Maiuri

Tamara Maiuri

9

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Alexander G Beristain

Alexander G Beristain

3

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Trevor McKee

Trevor D McKee

4

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Pingzhao Hu

Pingzhao Hu

8

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Vuk Stambolic

Vuk Stambolic

11

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Jeremy A. Squire

Jeremy Squire

12

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Josef Penninger

Josef Penninger

13

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Marco A Di Grappa

2

Marco A Di Grappa

1 reference

30 July 2017

18

Rama Khokha

1 reference

30 July 2017

Daniel H Wai

5

1 reference

30 July 2017

Jana Paderova

6

1 reference

30 July 2017

Meenakshi Kashyap

7

1 reference

30 July 2017

Swami R Narala

10

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30 July 2017

Otto Sanchez

14

1 reference

30 July 2017

Timothy J Triche

15

1 reference

30 July 2017

Geoffrey A Wood

16

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30 July 2017

Lawrence S Kirschner

17

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30 July 2017

language of work or name

English

0 references

publication date

9 August 2010

1 reference

Journal of Clinical Investigation

30 July 2017

1 reference

30 July 2017

120

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30 July 2017

9

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30 July 2017

3310-3325

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describes a project that uses

30 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2929719/fullTextXML

inferred from PubMed Central ID database lookup

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Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling

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Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression

28 July 2018

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Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice

28 July 2018

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Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

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28 July 2018

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28 July 2018

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Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

28 July 2018

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Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease

28 July 2018

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Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer

28 July 2018

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A review of clinical and molecular prognostic factors in osteosarcoma

28 July 2018

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Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A.

28 July 2018

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PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation

28 July 2018

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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

28 July 2018

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Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Protein kinase A and its role in human neoplasia: the Carney complex paradigm

28 July 2018

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Frequent amplification and rearrangement of chromosomal bands 6p12-p21 and 17p11.2 in osteosarcoma

28 July 2018

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Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis

28 July 2018

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Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein

28 July 2018

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28 July 2018

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28 July 2018

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Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex.

28 July 2018

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Common musculoskeletal tumors of childhood and adolescence

28 July 2018

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

An integrated genomic analysis of human glioblastoma multiforme

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

Secondary osteosarcoma arising in fibrous dysplasia, case report.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

The genomic landscapes of human breast and colorectal cancers

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

Identification of specific PP2A complexes involved in human cell transformation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

Osteosarcoma in a patient with McCune-Albright syndrome and Mazabraud's syndrome: a case report emphasizing the cytological and cytogenetic findings

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

Functional hierarchy between two OSE2 elements in the control of osteocalcin gene expression in vivo.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

c-fos expression induces bone tumors in transgenic mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2929719

Detection of c-fos expression in benign and malignant musculoskeletal lesions

28 October 2018

1 reference

12 December 2020

MDM2 gene amplification in metastatic osteosarcoma

1 reference

12 December 2020

Sporadic amplification of the MYC gene in human osteosarcomas

1 reference

12 December 2020

Clinical relevance of Ki-67 expression in bone tumors

1 reference

12 December 2020

The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit

1 reference

12 December 2020

CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons

1 reference

12 December 2020

A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues

1 reference

12 December 2020

Williams-Beuren syndrome diagnosis using fluorescence in situ hybridization

1 reference

12 December 2020

Osteochondromyxoma of bone: a congenital tumor associated with lentigines and other unusual disorders

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI42391

1 reference

30 July 2017

1 reference

30 July 2017

1 reference