The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone action (Q34092838)

31 July 2017

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title

The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone action (English)

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31 July 2017

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Heddle JG

1

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31 July 2017

Barnard FM

series ordinal

2

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31 July 2017

Wentzell LM

series ordinal

3

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31 July 2017

Maxwell A

series ordinal

4

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31 July 2017

publication date

1 August 2000

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Nucleosides, Nucleotides & Nucleic Acids

31 July 2017

number of pages

16

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based on heuristic

inferred from page(s)

published in

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31 July 2017

volume

19

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31 July 2017

issue

8

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31 July 2017

page(s)

1249-1264

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DNA gyrase: structure and function.

31 July 2017

cites work

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21 January 2018

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Crystal structure of an N-terminal fragment of the DNA gyrase B protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Crystal structure of the breakage-reunion domain of DNA gyrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Probing the two-gate mechanism of DNA gyrase using cysteine cross-linking.

21 January 2018

1 reference

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Locking the DNA gate of DNA gyrase: investigating the effects on DNA cleavage and ATP hydrolysis.

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770008033048

DNA gyrase as a drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Energy coupling in DNA gyrase and the mechanism of action of novobiocin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

An unusual mechanism for resistance to the antibiotic coumermycin A1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

21 January 2018

1 reference

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The Entropic Penalty of Ordered Water Accounts for Weaker Binding of the Antibiotic Novobiocin to a Resistant Mutant of DNA Gyrase: A Thermodynamic and Crystallographic Study

21 January 2018

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Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity

21 January 2018

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Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme

21 January 2018

1 reference

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Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones

21 January 2018

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https://api.crossref.org/works/10.1080%2F15257770008033048

Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

In vitro cleavable-complex assay to monitor antimicrobial potency of quinolones

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Topoisomerase IV is a target of quinolones in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

21 January 2018

1 reference

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Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Mechanism of action of quinolones against Escherichia coli DNA gyrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Nalidixic acid-resistant mutations of the gyrB gene of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Studies on the interaction of 4-quinolones with DNA by DNA unwinding experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

DNA unwinding induced by nalidixic acid binding to DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Quinolone binding to DNA is mediated by magnesium ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

DNA cleavage is not required for the binding of quinolone drugs to the DNA gyrase-DNA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Structure and mechanism of DNA topoisomerase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Conformational changes in DNA gyrase revealed by limited proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

Probing the Binding of Coumarins and Cyclothialidines to DNA Gyrase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

The DNA Gyrase-Quinolone Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F15257770008033048

10.1080/15257770008033048

21 January 2018

Identifiers

DOI

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31 July 2017

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