Granzymes in cancer and immunity (Q34092936)

31 July 2017

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title

Granzymes in cancer and immunity (English)

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31 July 2017

S P Cullen

1

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31 July 2017

M Brunet

series ordinal

2

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31 July 2017

S J Martin

series ordinal

3

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31 July 2017

language of work or name

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15 January 2010

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Cell Death & Differentiation

31 July 2017

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31 July 2017

17

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31 July 2017

4

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31 July 2017

616-623

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https://scigraph.springernature.com/pub.10.1038/cdd.2009.206

31 July 2017

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cites work

Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Mechanisms of granule-dependent killing

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Decreased tumor surveillance in perforin-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme-positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Human and mouse granzyme A induce a proinflammatory cytokine response.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Macrophages express granzyme B in the lesion areas of atherosclerosis and rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Expression of granzyme B in peripheral blood polymorphonuclear neutrophils (PMN), myeloid cell lines and in PMN derived from haemotopoietic stem cells in vitro

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Apoptosis induced by the lymphocyte effector molecule perforin

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Addressing the mysteries of perforin function.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Lymphocyte-mediated cytotoxicity.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme B: pro-apoptotic, antiviral and antitumor functions

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Human and murine granzyme B exhibit divergent substrate preferences

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

The major human and mouse granzymes are structurally and functionally divergent

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme C supports efficient CTL-mediated killing late in primary alloimmune responses

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Cell death induced by granzyme C.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme M mediates a novel form of perforin-dependent cell death

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Analysis of apoptosis in cell-free systems

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Immune surveillance: a balance between protumor and antitumor immunity

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Tumor Development after 3-Methylcholanthrene in Immunologically Deficient Athymic-Nude Mice

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Regulation of cutaneous malignancy by gammadelta T cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Differential tumor surveillance by natural killer (NK) and NKT cells.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Suppression of lymphoma and epithelial malignancies effected by interferon gamma

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

NKG2D recognition and perforin effector function mediate effective cytokine immunotherapy of cancer

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

The immunobiology of cancer immunosurveillance and immunoediting

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Transforming growth factor-beta in T-cell biology

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Regulatory T cells, tumour immunity and immunotherapy

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme B, a new player in activation-induced cell death, is down-regulated by vasoactive intestinal peptide in Th2 but not Th1 effectors

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Perforin-dependent apoptosis functionally compensates Fas deficiency in activation-induced cell death of human T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Increase in granzyme B+ lymphocytes and soluble granzyme B in bronchoalveolar lavage of allergen challenged patients with atopic asthma

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Increased airway granzyme b and perforin in current and ex-smoking COPD subjects

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

A lymphocyte serine protease granzyme A causes detachment of a small-intestinal epithelial cell line (IEC-6).

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme A is an interleukin 1 beta-converting enzyme

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

The caspase-1 inflammasome: a pilot of innate immune responses

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Perforin and Granzymes Have Distinct Roles in Defensive Immunity and Immunopathology

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

NF-kappa B activation mediates the cross-talk between extracellular matrix and interferon-gamma (IFN-gamma) leading to enhanced monokine induced by IFN-gamma (MIG) expression in macrophages

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Transforming growth factor-beta1 regulation of laminin gamma1 and fibronectin expression and survival of mouse mesangial cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Altered levels and molecular forms of granzyme k in plasma from septic patients.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme K: a novel mediator in acute airway inflammation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Noncytotoxic lytic granule-mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Four functionally distinct populations of human effector-memory CD8+ T lymphocytes.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Human keratinocytes acquire cellular cytotoxicity under UV-B irradiation. Implication of granzyme B and perforin

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

The danger model: a renewed sense of self

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Heat shock proteins: linking danger and pathogen recognition

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Activation of pro-urokinase by the human T cell-associated serine proteinase HuTSP-1.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Charge-dependent binding of granzyme A (MTSP-1) to basement membranes

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

The serine protease granzyme A does not induce platelet aggregation but inhibits responses triggered by thrombin.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Cutting Edge: Granzyme B Proteolysis of a Neuronal Glutamate Receptor Generates an Autoantigen and Is Modulated by Glycosylation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Antiangiogenic plasma activity in patients with systemic sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.206

7 January 2021

Identifiers

DOI

10.1038/CDD.2009.206

1 reference

Dimensions Publication ID

31 July 2017

1050017831

0 references

Fatcat ID

release_yct6h23flne5fejihpoddtujvu

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yct6h23flne5fejihpoddtujvu

24 November 2022

mapped directly with Wikidata item

1 reference