Regulatory T cells, tumour immunity and immunotherapy (Q36430144)

14 August 2017

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title

Regulatory T cells, tumour immunity and immunotherapy (English)

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14 August 2017

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Weiping Zou

1

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14 August 2017

1 April 2006

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Nature Reviews Immunology

14 August 2017

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14 August 2017

6

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14 August 2017

295-307

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14 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nri1806

14 August 2017

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cites work

Fatal attraction: tumors beckon regulatory T cells

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Immunosuppressor T cells in tumor bearing host

31 March 2020

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T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor

31 March 2020

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Generation and decay of the immune response to a progressive fibrosarcoma. II. Failure to demonstrate postexcision immunity after the onset of T cell-mediated suppression of immunity

31 March 2020

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Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1+2- suppressor T cells down-regulate the generation of Ly-1-2+ effector T cells

31 March 2020

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Control of regulatory T cell development by the transcription factor Foxp3

31 March 2020

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

31 March 2020

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

31 March 2020

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A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

31 March 2020

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Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells

31 March 2020

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Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes

31 March 2020

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Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4

31 March 2020

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Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis

31 March 2020

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Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells

31 March 2020

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Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma.

31 March 2020

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Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells

31 March 2020

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CD4+ CD25+ suppressor T cells: more questions than answers

31 March 2020

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The immunobiology of cancer immunosurveillance and immunoediting

31 March 2020

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Immunosuppressive networks in the tumour environment and their therapeutic relevance

31 March 2020

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Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

31 March 2020

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Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy

31 March 2020

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Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses

31 March 2020

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Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors

31 March 2020

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Depletion of CD4+ CD25+ regulatory cells augments the generation of specific immune T cells in tumor-draining lymph nodes

31 March 2020

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In vivo elimination of CD25+ regulatory T cells leads to tumor rejection of B16F10 melanoma, when combined with interleukin-12 gene transfer

31 March 2020

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Dendritic cells loaded with stressed tumor cells elicit long-lasting protective tumor immunity in mice depleted of CD4+CD25+ regulatory T cells

31 March 2020

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Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells.

31 March 2020

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Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens

31 March 2020

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CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination.

31 March 2020

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Regulatory T cells in ovarian cancer: biology and therapeutic potential

31 March 2020

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Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

31 March 2020

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Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma

31 March 2020

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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

31 March 2020

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Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells

31 March 2020

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CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.

31 March 2020

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Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

31 March 2020

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

31 March 2020

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

31 March 2020

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Enhancement of antitumor immunity by CTLA-4 blockade

31 March 2020

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Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer

31 March 2020

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Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy.

31 March 2020

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CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma.

31 March 2020

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Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accomp

31 March 2020

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CTLA-4 blockade enhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model

31 March 2020

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Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

31 March 2020

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Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

31 March 2020

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Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade

31 March 2020

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Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

31 March 2020

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Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T lymphocytes

31 March 2020

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Augmentation of specific immune response against a syngeneic SV40-induced sarcoma in mice by depletion of suppressor T cells with cyclophosphamide

31 March 2020

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Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

31 March 2020

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Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response

31 March 2020

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CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

31 March 2020

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Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells

31 March 2020

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Antigen-induced regulatory T cells in autoimmunity

31 March 2020

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Natural selection of tumor variants in the generation of "tumor escape" phenotypes

31 March 2020

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Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma

31 March 2020

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CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression

31 March 2020

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Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma

31 March 2020

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Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells.

31 March 2020

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Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma

31 March 2020

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Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells

31 March 2020

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Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

31 March 2020

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Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II

31 March 2020

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Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy

31 March 2020

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Regulatory T cell lineage specification by the forkhead transcription factor foxp3

31 March 2020

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Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals.

31 March 2020

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Mechanisms and functional significance of tumour-induced dendritic-cell defects

31 March 2020

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Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells

31 March 2020

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Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells

31 March 2020

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Regulatory T-cell response and tumor vaccine-induced cytotoxic T lymphocytes in human melanoma

31 March 2020

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Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation

31 March 2020

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Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells

31 March 2020

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CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.

31 March 2020

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

31 March 2020

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CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion

31 March 2020

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Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

31 March 2020

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Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus

31 March 2020

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Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

31 March 2020

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Interleukin-10 expressed at early tumour sites induces subsequent generation of CD4(+) T-regulatory cells and systemic collapse of antitumour immunity

31 March 2020

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Do suppressor T cells exist?

31 March 2020

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Tumor-specific human CD4+ regulatory T cells and their ligands: implications for immunotherapy

31 March 2020

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Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma.

31 March 2020

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Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors

31 March 2020

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Reciprocal changes in tumor antigenicity and antigen-specific T cell function during tumor progression

31 March 2020

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CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner

31 March 2020

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Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo

31 March 2020

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TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes

31 March 2020

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CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes

31 March 2020

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B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

31 March 2020

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Mechanisms of suppression by suppressor T cells

31 March 2020

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Interleukin-2 is essential for CD4+CD25+ regulatory T cell function

31 March 2020

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Human T regulatory cells can use the perforin pathway to cause autologous target cell death

31 March 2020

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Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

31 March 2020

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IDO expression by dendritic cells: tolerance and tryptophan catabolism

31 March 2020

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Modulation of tryptophan catabolism by regulatory T cells.

31 March 2020

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B7-H4, a molecule of the B7 family, negatively regulates T cell immunity

31 March 2020

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B7x: a widely expressed B7 family member that inhibits T cell activation

31 March 2020

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B7S1, a novel B7 family member that negatively regulates T cell activation

31 March 2020

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Definition of target antigens for naturally occurring CD4(+) CD25(+) regulatory T cells

31 March 2020

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CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients

31 March 2020

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Origin of regulatory T cells with known specificity for antigen

31 March 2020

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Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines

31 March 2020

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Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific

31 March 2020

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DAB(389)IL-2 (ONTAK): a novel fusion toxin therapy for lymphoma

31 March 2020

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Effects of immunosuppressants on induction of regulatory cells after intratracheal delivery of alloantigen

31 March 2020

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Inhibitory and stimulatory effects of cyclosporine A on the development of regulatory T cells in vivo

31 March 2020

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Interleukin 2 signaling is required for CD4(+) regulatory T cell function

31 March 2020

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Tolerance, not immunity, crucially depends on IL-2.

31 March 2020

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Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period

31 March 2020

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Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

31 March 2020

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Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function.

31 March 2020

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CD4+CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2.

31 March 2020

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Cancer vaccines: between the idea and the reality

31 March 2020

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IL-2-induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation

31 March 2020

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IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients

31 March 2020

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IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

31 March 2020

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Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.

31 March 2020

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Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia

31 March 2020

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Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4+CD25+ T cells

31 March 2020

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Characterization of Dendritic Cells that Induce Tolerance and T Regulatory 1 Cell Differentiation In Vivo

31 March 2020

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Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

31 March 2020

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Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans

31 March 2020

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Mature dendritic cells induce tumor-specific type 1 regulatory T cells

31 March 2020

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Immunology. Policing the immune system

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1806

1 reference

PubMed ID

16557261

Dimensions Publication ID

14 August 2017

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1 reference

PubMed ID

16557261