The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy (Q34093787)

31 July 2017

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy (English)

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31 July 2017

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Blagosklonny MV

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Neckers LM

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Trepel JB

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Fojo T

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Bhalla KN

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Kim JS

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Figg WD

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Rivera Y

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1 October 2001

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1537-1543

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2402257

31 July 2017

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Reversibility of acute B-cell leukaemia induced by BCR-ABL1.

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL.

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Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

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7 January 2021

Kinases: positive and negative regulators of apoptosis.

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

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7 January 2021

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

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7 January 2021

Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity

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7 January 2021

Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

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Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death

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Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells

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7 January 2021

Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia

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Dysregulation of apoptosis in cancer

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Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR–ABL tyrosine kinase, CGP 57148

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7 January 2021

Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells

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7 January 2021

In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor

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7 January 2021

Heat shock proteins--modulators of apoptosis in tumour cells

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7 January 2021

Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402257

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Dimensions Publication ID

31 July 2017

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