Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes (Q34101899)

31 July 2017

title

Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes (English)

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31 July 2017

Jian Yang

1

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31 July 2017

Chunshu Hao

2

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31 July 2017

Dongfang Yang

3

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31 July 2017

Deshi Shi

4

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31 July 2017

Xiulong Song

5

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31 July 2017

Xiaofei Luan

6

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31 July 2017

Gang Hu

7

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31 July 2017

Bingfang Yan

8

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31 July 2017

publication date

9 June 2010

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31 July 2017

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31 July 2017

volume

197

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31 July 2017

issue

3

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31 July 2017

page(s)

219-226

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Inflammation and altered drug clearance in cancer: transcriptional repression of a human CYP3A4 transgene in tumor-bearing mice

31 July 2017

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5 July 2018

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Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes

5 July 2018

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The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha

5 July 2018

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Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes.

5 July 2018

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Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor

5 July 2018

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Human PXR forms a tryptophan zipper-mediated homodimer

5 July 2018

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Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.

5 July 2018

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5 July 2018

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Review of the in vivo functions of the p160 steroid receptor coactivator family

5 July 2018

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Genetic contribution to variable human CYP3A-mediated metabolism

5 July 2018

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Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Regulation of cytochrome p450 by inflammatory mediators: why and how?

5 July 2018

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5 July 2018

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Cytochrome P-450 3A4: regulation and role in drug metabolism

5 July 2018

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

5 July 2018

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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28 October 2018

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Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents.

28 October 2018

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Simultaneous substitution of phenylalanine-305 and aspartate-318 of rat pregnane X receptor with the corresponding human residues abolishes the ability to transactivate the CYP3A23 promoter

28 October 2018

1 reference

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28 October 2018

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Serum and ascites levels of macrophage migration inhibitory factor, TNF-alpha and IL-6 in patients with chronic virus hepatitis B and hepatitis cirrhosis

28 October 2018

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Lipopolysaccharide and Cecal Ligation/Puncture Differentially Affect the Subcellular Distribution of the Pregnane X Receptor but Consistently Cause Suppression of Its Target Genes CYP3A

28 October 2018

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28 October 2018

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Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response

28 October 2018

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Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6

28 October 2018

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12 December 2020

Reduced urinary 6beta-hydroxycortisol to cortisol ratios in patients with liver cirrhosis

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12 December 2020

Impaired clearance of phenacetin in hepatic cirrhosis and fibrosis

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12 December 2020

Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved

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12 December 2020

Rapid induction of nuclear transcripts and inhibition of intron decay in response to the polymerase II inhibitor DRB

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12 December 2020

Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

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12 December 2020

The acute phase response

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12 December 2020

10.1016/J.TOXLET.2010.06.003

Identifiers

DOI

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31 July 2017

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31 July 2017

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