Drug-activated nuclear receptors CAR and PXR. (Q35160978)

6 August 2017

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title

Drug-activated nuclear receptors CAR and PXR. (English)

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6 August 2017

Paavo Honkakoski

1

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6 August 2017

Tatsuya Sueyoshi

series ordinal

2

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6 August 2017

Masahiko Negishi

series ordinal

3

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6 August 2017

language of work or name

English

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publication date

1 January 2003

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6 August 2017

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6 August 2017

35

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6 August 2017

3

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6 August 2017

172-182

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Inhibition and induction of human cytochrome P450 (CYP) enzymes

6 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Screening of drug candidates for their drug--drug interaction potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Enzyme induction in the cytochrome P-450 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Induction and drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

PXR, CAR and drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Regulation of cyp3a gene transcription by the pregnane x receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Genetic susceptibility to adverse effects of drugs and environmental toxicants. The role of the CYP family of enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Identification of the novel splicing variants for the hPXR in human livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

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https://api.crossref.org/works/10.1080%2F07853890310008224

In vitro and in vivo drug interactions involving human CYP3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

A pharmacophore for human pregnane X receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Use of the nuclear receptor PXR to predict drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated t

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Induction of drug metabolism by nuclear receptor CAR: molecular mechanisms and implications for drug research

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Suppression of the expression of the CYP2B1/2 gene by retinoic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Peroxisome proliferator-activated receptor-alpha mice show enhanced hepatocyte proliferation in response to the hepatomitogen 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene, a ligand of constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Retinoic acids repress constitutive active receptor-mediated induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene of the CYP2B10 gene in mouse primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Direct expression of fluorescent protein-tagged nuclear receptor CAR in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890310008224

10.1080/07853890310008224

21 January 2018

Identifiers

DOI

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6 August 2017

1 reference