Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine (Q34106544)

31 July 2017

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title

Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine (English)

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31 July 2017

Suzuki H

1

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PubMed ID

11121729

31 July 2017

Sugiyama Y

series ordinal

2

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PubMed ID

11121729

31 July 2017

language of work or name

English

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publication date

1 November 2000

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European Journal of Pharmaceutical Sciences

31 July 2017

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31 July 2017

12

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31 July 2017

3-12

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31 July 2017

1

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

31 July 2017

1 reference

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7 January 2021

Drug interactions with grapefruit juice

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7 January 2021

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

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7 January 2021

Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells

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7 January 2021

Polarized efflux of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein from cultured epithelial cell monolayers

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Active intestinal elimination of ciprofloxacin in rats: modulation by different substrates

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7 January 2021

Absorption and presystemic glucuronidation of 1-naphthol in the vascularly fluorocarbon emulsion perfused rat small intestine. The influence of 1-naphthol concentration, perfusate flow and noradrenaline

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7 January 2021

Hepatic, intestinal and renal transport of 1-naphthol-beta-D-glucuronide in mutant rats with hereditary-conjugated hyperbilirubinemia

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Cytochrome P450 3A: ontogeny and drug disposition

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Route-dependent metabolism of morphine in the vascularly perfused rat small intestine preparation

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7 January 2021

6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein

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7 January 2021

Net secretion of furosemide is subject to indomethacin inhibition, as observed in Caco-2 monolayers and excised rat jejunum

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7 January 2021

Tacrolimus oral bioavailability doubles with coadministration of ketoconazole

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7 January 2021

Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation

1 reference

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7 January 2021

Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance

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https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Calcein is excreted from the intestinal mucosal cell membrane by the active transport system

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7 January 2021

Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy

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7 January 2021

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine

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7 January 2021

Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil

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7 January 2021

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

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7 January 2021

Influence of grapefruit juice on cisapride pharmacokinetics

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7 January 2021

Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Evidence for different ABC-transporters in Caco-2 cells modulating drug uptake

1 reference

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7 January 2021

Effects of rifampin on tacrolimus pharmacokinetics in healthy volunteers

1 reference

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7 January 2021

Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3).

1 reference

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7 January 2021

ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3)

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7 January 2021

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

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7 January 2021

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption--theoretical approach

1 reference

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7 January 2021

Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid

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7 January 2021

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

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7 January 2021

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1 reference

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7 January 2021

Interaction between grapefruit juice and midazolam in humans.

1 reference

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7 January 2021

Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man

1 reference

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7 January 2021

Multidrug resistance mediated by the multidrug resistance protein (MRP) gene.

1 reference

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7 January 2021

Peptide transporters in the intestine and the kidney

1 reference

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7 January 2021

Grapefruit juice substantially increases plasma concentrations of buspirone

1 reference

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7 January 2021

Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors

1 reference

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7 January 2021

Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin

1 reference

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7 January 2021

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

1 reference

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7 January 2021

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

1 reference

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7 January 2021

Effects of grapefruit juice ingestion--pharmacokinetics and haemodynamics of intravenously and orally administered felodipine in healthy men.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells.

1 reference

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7 January 2021

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

1 reference

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7 January 2021

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

1 reference

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7 January 2021

Effect of oral pretreatment with indomethacin on the intestinal first-pass metabolism of salicylamide in rabbits

1 reference

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7 January 2021

Glutathione-conjugate transport by human colon adenocarcinoma cells (Caco-2 cells)

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

First-pass metabolism of midazolam by the human intestine.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Pharmacokinetics of felodipine in patients with liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Restricted intestinal absorption of some beta-lactam antibiotics by an energy-dependent efflux system in rat intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Effects of ketoconazole on digoxin absorption and disposition in rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Biliary excretion of glycyrrhizin in rats: kinetic basis for multiplicity in bile canalicular transport of organic anions

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Drug metabolism and metabolite transport in the small and large intestine: experiments with 1-naphthol and phenolphthalein by luminal and contraluminal administration in the isolated guinea pig mucosa.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

1-Naphthol metabolism and metabolite transport in the small and large intestine. II: Effect of sulphate and phosphate ion omission, and of 2,6-dichloro-4-nitrophenol in the isolated guinea pig mucosa

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

2-Naphthol metabolism and metabolite transport in the isolated guinea pig mucosa: further evidence for compartmentation of intestinal drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

In vitro and in vivo drug interactions involving human CYP3A.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

The barrier function of CYP3A4 and P-glycoprotein in the small bowel

1 reference

https://api.crossref.org/works/10.1016%2FS0928-0987%2800%2900178-0

7 January 2021

Vectorial release of sulfoconjugates in the vascularly perfused mouse small intestine

1 reference

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7 January 2021

10.1016/S0928-0987(00)00178-0

Identifiers

DOI

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31 July 2017

1 reference

PubMed ID

11121729