Dissection of the complex role of apolipoprotein E in lipoprotein metabolism and atherosclerosis using mouse models (Q34107200)

31 July 2017

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title

Dissection of the complex role of apolipoprotein E in lipoprotein metabolism and atherosclerosis using mouse models (English)

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31 July 2017

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van Dijk KW

1

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31 July 2017

Hofker MH

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2

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31 July 2017

Havekes LM

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3

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31 July 2017

1 September 1999

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Current Atherosclerosis Reports

31 July 2017

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31 July 2017

1

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31 July 2017

2

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31 July 2017

101-107

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https://scigraph.springernature.com/pub.10.1007/s11883-999-0005-y

31 July 2017

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cites work

Nascent very-low-density lipoprotein triacylglycerol hydrolysis by lipoprotein lipase is inhibited by apolipoprotein E in a dose-dependent manner

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https://api.crossref.org/works/10.1007%2FS11883-999-0005-Y

Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-999-0005-Y

Binding of beta-VLDL to heparan sulfate proteoglycans requires lipoprotein lipase, whereas ApoE only modulates binding affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-999-0005-Y

Expression of the VLDL receptor in endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-999-0005-Y

Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice

21 January 2018

1 reference

12 December 2020

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein

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12 December 2020

Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice

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12 December 2020

Apolipoprotein E polymorphism in The Netherlands and its effect on plasma lipid and apolipoprotein levels

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12 December 2020

Variable expression of familial dysbetalipoproteinemia in apolipoprotein E*2 (Lys146-->Gln) Allele carriers

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12 December 2020

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor

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12 December 2020

Atherosclerosis in APOE*3-Leiden transgenic mice: from proliferative to atheromatous stage

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12 December 2020

Chylomicron remnant clearance from the plasma is normal in familial hypercholesterolemic homozygotes with defined receptor defects

1 reference

12 December 2020

Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia

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12 December 2020

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity

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12 December 2020

Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo.

1 reference

12 December 2020

Low-dose expression of a human apolipoprotein E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein E-deficient mouse plasma

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12 December 2020

Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E

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12 December 2020

Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice

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12 December 2020

Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E

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12 December 2020

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

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12 December 2020

Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo

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12 December 2020

In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice

1 reference

12 December 2020

Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia

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12 December 2020

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

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12 December 2020

Apolipoprotein E as a risk factor for coronary heart disease: a genetic and molecular biology approach.

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12 December 2020

Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans

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12 December 2020

Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E.

1 reference

12 December 2020

Elimination of macrophage-specific apolipoprotein E reduces diet-induced atherosclerosis in C57BL/6J male mice

1 reference

12 December 2020

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery

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12 December 2020

Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.

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12 December 2020

Elevated levels of chylomicron- and VLDL-remnants leads to atherosclerosis in apoE transgenic mice

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12 December 2020

Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes

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12 December 2020

In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE

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12 December 2020

Apolipoprotein E effectively inhibits lipoprotein lipase-mediated lipolysis of chylomicron-like triglyceride-rich lipid emulsions in vitro and in vivo.

1 reference

12 December 2020

Triglyceride-rich lipoproteins of subjects heterozygous for apolipoprotein E2(Lysl46→Gln) are inefficiently converted to cholesterol-rich lipoproteins

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12 December 2020

Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression

1 reference

12 December 2020

Familial dysbetalipoproteinemia associated with apolipoprotein E3-Leiden in an extended multigeneration pedigree

1 reference

12 December 2020

Low density lipoprotein receptor internalizes low density and very low density lipoproteins that are bound to heparan sulfate proteoglycans via lipoprotein lipase

1 reference

12 December 2020

Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice

1 reference

12 December 2020

Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor

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12 December 2020

Endocytic mechanisms for uptake and metabolism of chylomicron remnants in the liver

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12 December 2020

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

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12 December 2020

Inefficient degradation of triglyceride-rich lipoprotein by HepG2 cells is due to a retarded transport to the lysosomal compartment

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12 December 2020

Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins.

1 reference

12 December 2020

The role of apolipoprotein E genetic variants in lipoprotein disorders

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12 December 2020

Apolipoprotein E secretion by macrophages: its potential physiological functions.

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12 December 2020

Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia

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12 December 2020

Effect of apolipoprotein E variants on lipolysis of very low density lipoproteins by heparan sulphate proteoglycan-bound lipoprotein lipase

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12 December 2020

Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis

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12 December 2020

Role of apolipoprotein E in the lipolytic conversion of beta-very low density lipoproteins to low density lipoproteins in type III hyperlipoproteinemia

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12 December 2020

Recycling of apolipoprotein E in mouse liver

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12 December 2020

The pathogenesis of atherosclerosis: a perspective for the 1990s

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12 December 2020

Both lipolysis and hepatic uptake of VLDL are impaired in transgenic mice coexpressing human apolipoprotein E*3Leiden and human apolipoprotein C1

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12 December 2020

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

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12 December 2020

Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

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12 December 2020

Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

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12 December 2020

10.1007/S11883-999-0005-Y

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Dimensions Publication ID

31 July 2017

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