Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression (Q34111025)

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English	Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression	scientific article

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scholarly article

1 reference

Europe PubMed Central

31 July 2017

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Europe PubMed Central

Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression (English)

1 reference

Europe PubMed Central

31 July 2017

Alzheimer's disease

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author name string

Pettegrew JW

1

1 reference

Europe PubMed Central

31 July 2017

Levine J

2

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Europe PubMed Central

31 July 2017

McClure RJ

3

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Europe PubMed Central

31 July 2017

language of work or name

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publication date

1 November 2000

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Europe PubMed Central

31 July 2017

Molecular Psychiatry

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Europe PubMed Central

31 July 2017

5

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Europe PubMed Central

31 July 2017

6

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Europe PubMed Central

31 July 2017

616-632

1 reference

Europe PubMed Central

31 July 2017

https://scigraph.springernature.com/pub.10.1038/sj.mp.4000805

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Carnitine Acetyltransferase: the Question of Multiple Forms

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Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type.

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High uptake of [2-11C]acetyl-L-carnitine into the brain: a PET study.

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Acetyl-L-carnitine modulates glucose metabolism and stimulates glycogen synthesis in rat brain.

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Progressive decrease of cerebral cytochrome C oxidase activity in sparse-fur mice: role of acetyl-L-carnitine in restoring the ammonia-induced cerebral energy depletion.

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Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine

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Purinoceptors in the nervous system.

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Neuroprotective role of adenosine in cerebral ischaemia

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Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport

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Adenosine modulates hypoxia-induced responses in rat PC12 cells via the A2A receptor

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Aging brain: effect of acetyl-L-carnitine treatment on rat brain energy and phospholipid metabolism. A study by 31P and 1H NMR spectroscopy.

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Acetyl-L-carnitine influences the fluidity of brain microsomes and of liposomes made of rat brain microsomal lipid extracts.

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Effect of L-carnitine and acetyl-L-carnitine on the human erythrocyte membrane stability and deformability

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The Structure of Cytochrome b5 at 2.0 A Resolution

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Nerve growth factor binding in aged rat central nervous system: effect of acetyl-L-carnitine

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Acetyl-l-carnitine enhances the response of PC12 cells to nerve growth factor

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Stimulation of nerve growth factor receptors in PC12 by acetyl-L-carnitine

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Neurite outgrowth in PC12 cells stimulated by acetyl-L-carnitine arginine amide.

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Acetyl-L-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats.

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Acetyl-L-carnitine treatment increases choline acetyltransferase activity and NGF levels in the CNS of adult rats following total fimbria-fornix transection.

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Spatial memory and NGF levels in aged rats: natural variability and effects of acetyl-L-carnitine treatment.

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New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor

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Action of L-acetylcarnitine on different cerebral mitochondrial populations from cerebral cortex.

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Brain enzyme activities after intracerebroventricular injection of streptozotocin in rats receiving acetyl-L-carnitine.

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Protein kinase C activation and anti-amnesic effect of acetyl-L-carnitine: in vitro and in vivo studies.

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Effect of acetyl-L-carnitine treatment on brain adenylate cyclase activity in young and aged rats.

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Action of L-acetylcarnitine on different cerebral mitochondrial populations from hippocampus and striatum during aging

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1.9-A structures of ternary complexes of citrate synthase with D- and L-malate: mechanistic implications

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Sequence analysis of a proteolyzed site in Drosophila choline acetyltransferase

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Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+

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Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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Stimulation of gonadotropin-releasing hormone secretion by acetyl-L-carnitine in hypothalamic neurons and GT1 neuronal cells

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Effect of different chronic intermittent stressors and acetyl-l-carnitine on hypothalamic beta-endorphin and GnRH and on plasma testosterone levels in male rats.

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Actions of acetyl-L-carnitine on the hypothalamo-pituitary-gonadal system in female rats

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Acetyl-L-carnitine has a neuromodulatory influence on neuronal phenotypes during early embryogenesis in the chick embryo

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Dynamic morphology of the synaptic junctional areas during aging: the effect of chronic acetyl-L-carnitine administration.

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Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions

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Acetyl-L-carnitine: behavioral, electrophysiological, and neurochemical effects.

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Acetyl-L-carnitine restores choline acetyltransferase activity in the hippocampus of rats with partial unilateral fimbria-fornix transection.

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Spatial discrimination learning and choline acetyltransferase activity in streptozotocin-treated rats: effects of chronic treatment with acetyl-L-carnitine.

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Acetyl-L-carnitine affects aged brain receptorial system in rodents

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Acetyl-L-carnitine releases dopamine in rat corpus striatum: an in vivo microdialysis study

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Acetyl-L-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats

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Effect of acetyl-L-carnitine on the dopaminergic system in aging brain

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Systemic acetyl-L-carnitine elevates nigral levels of glutathione and GABA.

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Stereospecific effects of acetylcarnitine on the spontaneous activity of brainstem neurones and their responses to acetylcholine and serotonin.

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Effect of acetyl-L-carnitine on extracellular amino acid levels in vivo in rat brain regions.

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Neuroprotective activity of acetyl-L-carnitine: studies in vitro.

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Activation of apoptosis by serum deprivation in a teratocarcinoma cell line: inhibition by L-acetylcarnitine

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Effect of acetyl-L-carnitine on hyperactivity and spatial memory deficits of rats exposed to neonatal anoxia.

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Acetyl-L-Carnitine: chronic treatment improves spatial acquisition in a new environment in aged rats.

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Long-term acetyl-L-carnitine treatment in Alzheimer's disease

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Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease.

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Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease.

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Evidence for a membrane defect in Alzheimer disease brain

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Synaptic pathology of Alzheimer's disease

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Synapse alterations in the hippocampal-entorhinal formation in Alzheimer's disease with and without Lewy body disease.

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Reduced O-glycosylated clathrin assembly protein AP180: implication for synaptic vesicle recycling dysfunction in Alzheimer's disease.

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Serum lipid concentrations in patients with major depressive disorder.

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Effects of lithium treatment in vitro and in vivo on acetylcholine metabolism in rat brain

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Chronic lithium treatment decreases brain phospholipase A2 activity.

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Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex.

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Lithium stimulation of membrane-bound phospholipase C from PC12 cells exposed to nerve growth factor.

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The lipid structure of biological membranes

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Polymorphic regulation of membrane lipid composition

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Return of the magnificent seven

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EFFECTS OF CARNITINE ON ACETYL-COA OXIDATION BY HEART MUSCLE MITOCHONDRIA

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Biosynthesis and turnover of carnitine acetyltransferase in rat liver

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7 January 2021

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Carnitines increase plasma levels of adenosine and ATP in humans

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7 January 2021

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Action of L-acetylcarnitine on age-dependent modifications of mitochondrial membrane proteins from rat cerebellum

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Acetylcarnitine increases membrane cytoskeletal protein-protein interactions

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The effect of aging and acetyl-L-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria

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7 January 2021

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7 January 2021

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7 January 2021

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Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach.

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7 January 2021

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ESR studies of the erythrocyte membrane skeletal protein network: influence of the state of aggregation of spectrin on the physical state of membrane proteins, bilayer lipids, and cell surface carbohydrates

1 reference

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7 January 2021

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Electrostatic coupling of spectrin dimers to phosphatidylserine containing lipid lamellae

1 reference

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7 January 2021

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Lower serum high-density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: relationship with immune-inflammatory markers

1 reference

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7 January 2021

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Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients

1 reference

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7 January 2021

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Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients

1 reference

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7 January 2021

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Abnormalities of one-carbon metabolism in psychiatric disorders: study of methionine adenosyltransferase kinetics and lipid composition of erythrocyte membranes

1 reference

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7 January 2021

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Treatment outcome in recurrent major depression: a post hoc comparison of elderly ("young old") and midlife patients

1 reference

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7 January 2021

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The effect of myo-inositol deficiency on lipid metabolism in rats. II. The mechanism of triacylglycerol accumulation in the liver of myo-inositol-deficient rats

1 reference

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7 January 2021

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Chronic myo-inositol increases rat brain phosphatidylethanolamine plasmalogen

1 reference

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7 January 2021

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Plasmenylethanolamine facilitates rapid membrane fusion: a stopped-flow kinetic investigation correlating the propensity of a major plasma membrane constituent to adopt an HII phase with its ability to promote membrane fusion

1 reference

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7 January 2021

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Acetyl-L-carnitine deficiency as a cause of altered nerve myo-inositol content, Na,K-ATPase activity, and motor conduction velocity in the streptozotocin-diabetic rat

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4000805

7 January 2021

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Systemic lithium administration alters rat cerebral cortex phospholipids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4000805

7 January 2021

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Evidence that Lithium Alters Phosphoinositide Metabolism: Chronic Administration Elevates Primarily d-myo-Inositol-1-Phosphate in Cerebral Cortex of the Rat

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4000805

7 January 2021

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Identifiers

10.1038/SJ.MP.4000805

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

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