Human genomics and obesity: finding appropriate drug targets. (Q34116512)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11134665%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

review article

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title

Human genomics and obesity: finding appropriate drug targets (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11134665%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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2

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3 November 2019

author name string

Ravussin E

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11134665%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

language of work or name

English

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publication date

1 December 2000

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11134665%20AND%20SRC:MED&resulttype=core&format=json

European Journal of Pharmacology

3 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11134665%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

volume

410

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11134665%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

issue

2-3

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3 November 2019

page(s)

131-145

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11134665%20AND%20SRC:MED&resulttype=core&format=json

Investigation of the melanocyte stimulating hormones on food intake. Lack Of evidence to support a role for the melanocortin-3-receptor

3 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

In vivo modulation of Hmgic reduces obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Meta-analysis of resting metabolic rate in formerly obese subjects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Genetics of body-weight regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Comparison of central administration of corticotropin-releasing hormone and urocortin on food intake, conditioned taste aversion, and c-Fos expression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Adenosine deaminase and body mass index in non-insulin-dependent diabetes mellitus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

The response to exercise with constant energy intake in identical twins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Modulation of Urocortin-Induced Hypophagia and Weight Loss by Corticotropin-Releasing Factor Receptor 1 Deficiency in Mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Obesity, A Disorder Of Nutrient Partitioning: The MONA LISA Hypothesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Current and potential drugs for treatment of obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Sibutramine produces dose-related weight loss

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Pharmacology of nociceptin and its receptor: a novel therapeutic target

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Genome-wide search for genes related to the fat-free body mass in the Québec family study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

The human obesity gene map: the 1999 update.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

The N-terminal domain of rat liver carnitine palmitoyltransferase 1 mediates import into the outer mitochondrial membrane and is essential for activity and malonyl-CoA sensitivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Haploinsufficiency of the melanocortin-4 receptor: part of a thrifty genotype?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Sibutramine and thermogenesis in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Body-build and its inheritance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Food intake regulation in rodents: Y5 or Y1 NPY receptors or both?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Cocaine- and amphetamine-regulated transcript, glucagon-like peptide-1 and corticotrophin releasing factor inhibit feeding via agouti-related protein independent pathways in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

An "ecological" approach to the obesity pandemic

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Enterostatin--a peptide regulating fat intake

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Stimulation of food intake by muscimol and beta endorphin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Pharmacology of appetite suppression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Several Mutations in the Melanocortin-4 Receptor Gene Including a Nonsense and a Frameshift Mutation Associated with Dominantly Inherited Obesity in Humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Identification of receptors for neuromedin U and its role in feeding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Leptin: a multifunctional hormone

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Association of polymorphisms in the beta2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Thioperamide, a histamine H3 receptor antagonist, powerfully suppresses peptide YY-induced food intake in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Familial risk of obesity and central adipose tissue distribution in the general Canadian population

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Linkage and Association of the Sodium Potassium-Adenosine Triphosphatase 2 and 1 Genes with Respiratory Quotient and Resting Metabolic Rate in the Quebec Family Study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Obesity in the Pima Indians: its magnitude and relationship with diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Synergic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on weight loss in obese Japanese

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Hypothalamic CART is a new anorectic peptide regulated by leptin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Stimulation of feeding by galanin: Anatomical localization and behavioral specificity of this peptide's effects in the brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

A role for neuropeptide-Y, dynorphin, and noradrenaline in the central control of food intake after food deprivation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Familial risk ratios for extreme obesity: implications for mapping human obesity genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Genome scan for human obesity and linkage to markers in 20q13.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Genetic and environmental factors in relative body weight and human adiposity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Congenital leptin deficiency is associated with severe early-onset obesity in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Peripherally administered calcitonin gene-related peptide decreases food intake in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

The mahogany protein is a receptor involved in suppression of obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

The "thrifty genotype" in 1998

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

A candidate gene for the mouse mutation tubby

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Effects of the obese gene product on body weight regulation in ob/ob mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

A brief overview of human energy metabolism and its relationship to essential obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Metabolic predictors of weight gain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Reduced rate of energy expenditure as a risk factor for body-weight gain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Effects of a traditional lifestyle on obesity in Pima Indians

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Amylin and insulin interact to reduce food intake in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

The cost of obesity: the Australian perspective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Time trends in obesity: an epidemiological perspective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Assessing obesity: classification and epidemiology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Mice lacking melanin-concentrating hormone are hypophagic and lean

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. European Multicentre Orlistat Study Group

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Neurotensin: effects of hypothalamic and intravenous injections on eating and drinking in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

A leptin missense mutation associated with hypogonadism and morbid obesity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Identification and expression cloning of a leptin receptor, OB-R

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Ghrelin induces adiposity in rodents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

A frameshift mutation in human MC4R is associated with a dominant form of obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Glucagon-like peptide-1 (7-36) amide: a central regulator of satiety and interoceptive stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Behavioural treatment of the overweight patient

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

The PPARs: from orphan receptors to drug discovery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Structure and function of ASP, the human homolog of the mouse agouti gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Current estimates of the economic cost of obesity in the United States

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

A frameshift mutation in MC4R associated with dominantly inherited human obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Positional cloning of the mouse obese gene and its human homologue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2800%2900811-6

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0014-2999(00)00811-6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11134665%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference