A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain (Q34118030)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510930%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

title

A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain (English)

1 reference

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4 February 2020

2

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4 February 2020

6

David Julius

1 reference

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4 February 2020

author name string

Christopher J Bohlen

1

1 reference

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4 February 2020

Sharleen Zhou

3

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4 February 2020

David King

4

1 reference

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4 February 2020

Jan Siemens

5

1 reference

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4 February 2020

language of work or name

English

0 references

publication date

1 May 2010

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4 February 2020

1 reference

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4 February 2020

volume

141

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4 February 2020

issue

5

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4 February 2020

page(s)

834-845

1 reference

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Structural and functional characterization of a novel homodimeric three-finger neurotoxin from the venom of Ophiophagus hannah (king cobra)

4 February 2020

cites work

1 reference

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Interactions between lipids and voltage sensor paddles detected with tarantula toxins

5 July 2018

1 reference

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Polypeptide and peptide toxins, magnifying lenses for binding sites in nicotinic acetylcholine receptors.

5 July 2018

1 reference

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A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors

5 July 2018

1 reference

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Rapid sensitive analysis of cysteine rich peptide venom components.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Pore region of TRPV3 ion channel is specifically required for heat activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Sensing voltage across lipid membranes

5 July 2018

1 reference

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Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane

5 July 2018

1 reference

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A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating

5 July 2018

1 reference

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Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Portability of paddle motif function and pharmacology in voltage sensors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Folding of conotoxins: formation of the native disulfide bridges during chemical synthesis and biosynthesis of Conus peptides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Voltage is a partial activator of rat thermosensitive TRP channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

5 July 2018

1 reference

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Voltage-gated ion channels and gating modifier toxins.

5 July 2018

1 reference

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Tarantula toxins interacting with voltage sensors in potassium channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Spider toxins activate the capsaicin receptor to produce inflammatory pain.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

How does voltage open an ion channel?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

An introduction to TRP channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Conformational changes of pore helix coupled to gating of TRPV5 by protons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Voltage-sensor activation with a tarantula toxin as cargo.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

An overview of peptide toxins from the venom of the Chinese bird spider Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)].

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Tarantulas: eight-legged pharmacists and combinatorial chemists

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Molecular determinants of vanilloid sensitivity in TRPV1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Conus venoms: a rich source of novel ion channel-targeted peptides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

The KNOTTIN website and database: a new information system dedicated to the knottin scaffold.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Evolutionary origin of inhibitor cystine knot peptides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Molecular mechanisms of nociception

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

The cystine knot motif in toxins and implications for drug design.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Localization and molecular determinants of the Hanatoxin receptors on the voltage-sensing domains of a K(+) channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Molecular genetics of ecological diversification: duplication and rapid evolution of toxin genes of the venomous gastropod Conus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

The charybdotoxin family of K+ channel-blocking peptides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

The charybdotoxin receptor of a Shaker K+ channel: peptide and channel residues mediating molecular recognition.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

cDNA sequence analysis of seven peptide toxins from the spider Selenocosmia huwena.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Interaction between extracellular Hanatoxin and the resting conformation of the voltage-sensor paddle in Kv channels

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Molecular basis for species-specific sensitivity to "hot" chili peppers

28 October 2018

1 reference

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Transfer of the scorpion toxin receptor to an insensitive potassium channel.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2905675

Spanning binding sites on allosteric proteins with polymer-linked ligand dimers

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20510930

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2010.03.052

Identifiers

DOI

10.1016/J.CELL.2010.03.052

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510930%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510930%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference