IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. (Q34120958)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20026737%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis (English)

1 reference

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15 January 2020

0 references

1 reference

10

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15 January 2020

11

Richard S Hotchkiss

1 reference

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15 January 2020

9

Craig M Coopersmith

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15 January 2020

author name string

Shigeaki Inoue

1

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15 January 2020

Jacqueline Unsinger

2

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15 January 2020

Christopher G Davis

3

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15 January 2020

Jared T Muenzer

4

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15 January 2020

Thomas A Ferguson

5

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15 January 2020

Katherine Chang

6

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15 January 2020

Dale F Osborne

7

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15 January 2020

Andrew T Clark

8

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15 January 2020

language of work or name

English

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publication date

21 December 2009

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15 January 2020

published in

Journal of Immunology

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15 January 2020

volume

184

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15 January 2020

issue

3

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15 January 2020

page(s)

1401-1409

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Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis

15 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

The sepsis seesaw: tilting toward immunosuppression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Targeted delivery of siRNA to cell death proteins in sepsis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Cytomegalovirus reactivation in critically ill immunocompetent patients

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

The apoptotic pathway as a therapeutic target in sepsis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Dendritic cells prime natural killer cells by trans-presenting interleukin 15

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Apoptosis and caspases regulate death and inflammation in sepsis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

The disconnect between animal models of sepsis and human sepsis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

The role of BH3-only proteins in the immune system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Injury, sepsis, and the regulation of Toll-like receptor responses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

The pathophysiology and treatment of sepsis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Cytokines in host defense against Salmonella

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

IL-15 and IL-2: a matter of life and death for T cells in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Interleukin 15: biology and relevance to human disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Interleukin-7 or interleukin-15 enhances survival of Mycobacterium tuberculosis-infected mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

The pleiotropic functions of interleukin 15: not so interleukin 2-like after all.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Effect of sepsis on tissue adenine nucleotide levels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Interleukin-15 protects from lethal apoptosis in vivo.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937828

Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis

28 October 2018

1 reference

12 December 2020

Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-alpha-induced apoptosis

1 reference

12 December 2020

Monocyte deactivation in septic patients: restoration by IFN-gamma treatment

1 reference

12 December 2020

Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis

1 reference

12 December 2020

Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis

1 reference

12 December 2020

Pathophysiology of sepsis

1 reference

12 December 2020

IL-15-induced CD8+CD122+ T cells increase antibacterial and anti-tumor immune responses: implications for immune function in aged mice

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.0902307

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20026737%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20026737%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference