The role of BH3-only proteins in the immune system (Q36047162)

11 August 2017

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title

The role of BH3-only proteins in the immune system (English)

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11 August 2017

Andreas Strasser

1

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language of work or name

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1 March 2005

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Nature Reviews Immunology

11 August 2017

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11 August 2017

5

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11 August 2017

3

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11 August 2017

189-200

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https://scigraph.springernature.com/pub.10.1038/nri1568

11 August 2017

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cites work

Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more

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31 March 2020

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Cell death: critical control points

31 March 2020

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Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

31 March 2020

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Fas ligand-induced apoptosis

31 March 2020

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bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

31 March 2020

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Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

31 March 2020

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Bcl-2 expression promotes B- but not T-lymphoid development in scid mice

31 March 2020

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Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene

31 March 2020

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Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

31 March 2020

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A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

31 March 2020

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FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

31 March 2020

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Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer

31 March 2020

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31 March 2020

T cell death and memory

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T-lymphocyte death during shutdown of an immune response

31 March 2020

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Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.

31 March 2020

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The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

31 March 2020

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The molecular biology of apoptosis

31 March 2020

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Mechanisms of caspase activation and inhibition during apoptosis

31 March 2020

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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

31 March 2020

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DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

31 March 2020

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Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

31 March 2020

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FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

31 March 2020

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Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

31 March 2020

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Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

31 March 2020

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The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.

31 March 2020

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Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

31 March 2020

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Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

31 March 2020

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

31 March 2020

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BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

31 March 2020

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The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

31 March 2020

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

31 March 2020

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Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

31 March 2020

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Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

31 March 2020

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Testicular degeneration in Bclw-deficient mice

31 March 2020

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Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant

31 March 2020

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Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation

31 March 2020

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Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

31 March 2020

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Structure of Bax: coregulation of dimer formation and intracellular localization

31 March 2020

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

31 March 2020

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Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

31 March 2020

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Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

31 March 2020

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The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

31 March 2020

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

31 March 2020

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BH3-Only proteins-essential initiators of apoptotic cell death

31 March 2020

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

31 March 2020

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Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K

31 March 2020

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Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist

31 March 2020

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BID: a novel BH3 domain-only death agonist

31 March 2020

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harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

31 March 2020

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Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death

31 March 2020

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

31 March 2020

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31 March 2020

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

31 March 2020

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PUMA, a novel proapoptotic gene, is induced by p53

31 March 2020

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PUMA induces the rapid apoptosis of colorectal cancer cells

31 March 2020

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Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

31 March 2020

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Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

31 March 2020

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The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

31 March 2020

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

31 March 2020

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

31 March 2020

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Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

31 March 2020

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

31 March 2020

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

31 March 2020

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Movement of Bax from the cytosol to mitochondria during apoptosis

31 March 2020

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The Bcl2 family: regulators of the cellular life-or-death switch

31 March 2020

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The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

31 March 2020

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Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

31 March 2020

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The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

31 March 2020

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Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival

31 March 2020

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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

31 March 2020

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Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

31 March 2020

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Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim

31 March 2020

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Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

31 March 2020

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Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

31 March 2020

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Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

31 March 2020

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CD95's deadly mission in the immune system

31 March 2020

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Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide

31 March 2020

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Fas ligand mediates activation-induced cell death in human T lymphocytes

31 March 2020

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

31 March 2020

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

31 March 2020

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Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

31 March 2020

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Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

31 March 2020

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Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

31 March 2020

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JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

31 March 2020

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JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

31 March 2020

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Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

31 March 2020

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Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

31 March 2020

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Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

31 March 2020

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Pro-apoptotic BH3-only Bcl-2 family members in vertebrate model organisms suitable for genetic experimentation

31 March 2020

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DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

31 March 2020

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

31 March 2020

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

31 March 2020

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Integral role of Noxa in p53-mediated apoptotic response

31 March 2020

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

31 March 2020

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

31 March 2020

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

31 March 2020

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Bad-deficient mice develop diffuse large B cell lymphoma

31 March 2020

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Solution structure of BID, an intracellular amplifier of apoptotic signaling

31 March 2020

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Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

31 March 2020

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

31 March 2020

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

31 March 2020

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Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

31 March 2020

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Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

31 March 2020

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Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis

31 March 2020

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Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death

31 March 2020

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Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death.

31 March 2020

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

31 March 2020

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

31 March 2020

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Proapoptotic BID is required for myeloid homeostasis and tumor suppression

31 March 2020

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Bim is a suppressor of Myc-induced mouse B cell leukemia

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Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors

31 March 2020

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Delineating the genetic basis of systemic lupus erythematosus

31 March 2020

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Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

31 March 2020

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Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice

31 March 2020

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Loss of Bim allows precursor B cell survival but not precursor B cell differentiation in the absence of interleukin 7

31 March 2020

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Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

31 March 2020

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CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

31 March 2020

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Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

31 March 2020

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Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL

31 March 2020

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Bcl-G, a novel pro-apoptotic member of the Bcl-2 family

31 March 2020

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Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1568

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PubMed ID

15719025

Dimensions Publication ID

11 August 2017

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PubMed ID

15719025