Protein phosphatase 2Cbetal regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. (Q34127902)

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5 February 2020

title

Protein phosphatase 2Cbetal regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells (English)

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5 February 2020

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Satyanarayana R Pondugula

1

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5 February 2020

author name string

Alexander A Tong

2

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5 February 2020

Jing Wu

3

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5 February 2020

Jimmy Cui

4

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5 February 2020

Taosheng Chen

5

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5 February 2020

publication date

10 June 2010

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Drug Metabolism and Disposition

5 February 2020

published in

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5 February 2020

volume

38

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5 February 2020

issue

9

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5 February 2020

page(s)

1411-1416

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Augmenter of liver regeneration causes different kinetics of ERK1/2 and Akt/PKB phosphorylation than EGF and induces hepatocyte proliferation in an EGF receptor independent and liver specific manner

5 February 2020

cites work

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5 July 2018

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PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation

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Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells

5 July 2018

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5 July 2018

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Protein phosphatases types 2Calpha and 2Cbeta in apoptosis

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PP2C family members play key roles in regulation of cell survival and apoptosis

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Purification of full-length human pregnane and xenobiotic receptor: polyclonal antibody preparation for immunological characterization

5 July 2018

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Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT).

5 July 2018

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Repression of cytochrome P450 activity in human hepatocytes in vitro by a novel hepatotrophic factor, augmenter of liver regeneration

5 July 2018

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Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity

5 July 2018

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5 July 2018

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Uniquely conserved non-translated regions are involved in generation of the two major transcripts of protein phosphatase 2Cbeta

5 July 2018

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Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms

5 July 2018

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Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases

5 July 2018

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Cytochrome P-450 3A4: regulation and role in drug metabolism

5 July 2018

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

5 July 2018

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The cloning expression and tissue distribution of human PP2Cbeta

5 July 2018

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

5 July 2018

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A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor

5 July 2018

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Cyclic AMP-dependent protein kinase signaling modulates pregnane x receptor activity in a species-specific manner

28 October 2018

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Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents.

28 October 2018

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28 October 2018

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Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway

28 October 2018

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A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand

28 October 2018

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Regulation of phenobarbital induction of the cytochrome P450 2b9/10 genes in primary mouse hepatocyte culture. Involvement of calcium- and cAMP-dependent pathways

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20538721

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20538721

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytes in primary culture

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20538721

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/DMD.110.032128

1 reference

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5 February 2020

1 reference

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5 February 2020

PubMed publication ID

20538721

1 reference