Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression (Q37284901)

19 August 2017

1 reference

title

Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression (English)

1 reference

protein-protein interaction

19 August 2017

0 references

1 reference

inferred from title

author name string

Satyanarayana R Pondugula

series ordinal

1

1 reference

19 August 2017

Hanqing Dong

series ordinal

2

1 reference

19 August 2017

Taosheng Chen

series ordinal

3

1 reference

19 August 2017

language of work or name

English

0 references

publication date

1 August 2009

1 reference

Expert Opinion on Drug Metabolism & Toxicology

19 August 2017

1 reference

19 August 2017

5

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19 August 2017

8

1 reference

19 August 2017

861-873

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Using ontogeny information to build predictive models for drug elimination

19 August 2017

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Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4.

6 September 2017

1 reference

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Inflammation and altered drug clearance in cancer: transcriptional repression of a human CYP3A4 transgene in tumor-bearing mice

6 September 2017

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PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy

6 September 2017

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Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes

6 September 2017

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6 September 2017

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Inflammation and CYP3A4-mediated drug metabolism in advanced cancer: impact and implications for chemotherapeutic drug dosing

6 September 2017

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Ontogeny of human hepatic cytochromes P450.

6 September 2017

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The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.

6 September 2017

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Steroid receptor phosphorylation: a key modulator of multiple receptor functions

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Human PXR forms a tryptophan zipper-mediated homodimer

6 September 2017

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6 September 2017

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6 September 2017

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Liver regeneration: from myth to mechanism

6 September 2017

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Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes

6 September 2017

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Modulation of glucocorticoid receptor function via phosphorylation.

6 September 2017

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Cytochrome P450 regulation and drug biotransformation during inflammation and infection

6 September 2017

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Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reporting

6 September 2017

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The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation

6 September 2017

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6 September 2017

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6 September 2017

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The role of cytokines in liver failure and regeneration: potential new molecular therapies

6 September 2017

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The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

6 September 2017

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

6 September 2017

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Alteration of drug biotransformation and elimination during infection and inflammation

6 September 2017

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Regulation of cytochrome p450 by inflammatory mediators: why and how?

6 September 2017

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The regulation of protein function by multisite phosphorylation--a 25 year update

6 September 2017

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Protein-protein interactions define specificity in signal transduction

6 September 2017

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Increased activity of MAP, p70S6 and p90rs kinases is associated with AP-1 activation in spontaneous liver tumours, but not in adjacent tissue in mice.

6 September 2017

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Modulating nuclear receptor function: may the phos be with you

6 September 2017

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Cytochrome P-450 3A4: regulation and role in drug metabolism

6 September 2017

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

6 September 2017

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

6 September 2017

1 reference

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Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies

6 September 2017

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Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-kappaB.

6 September 2017

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

6 September 2017

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6 September 2017

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Differential suppression by protease inhibitors and cytokines of apoptosis induced by wild-type p53 and cytotoxic agents

6 September 2017

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Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration

6 September 2017

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Altered expression of cytochrome P450 mRNA during chemical-induced hepatocarcinogenesis and following partial hepatectomy

6 September 2017

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Phosphorylation of steroid hormone receptors

6 September 2017

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Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1.

6 September 2017

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Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells

14 September 2017

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Human pregnane X receptor and resistance to chemotherapy in prostate cancer

14 September 2017

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Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localization

14 September 2017

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Purification of full-length human pregnane and xenobiotic receptor: polyclonal antibody preparation for immunological characterization

14 September 2017

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Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver

14 September 2017

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Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450.

14 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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26 June 2018

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26 June 2018

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26 June 2018

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Evaluation of the xenobiotic biotransformation capability of six rodent hepatoma cell lines in comparison with rat hepatocytes

26 June 2018

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26 June 2018

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Tumor necrosis factor production by Kupffer cells requires protein kinase C activation.

26 June 2018

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A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor

26 June 2018

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Cyclic AMP-dependent protein kinase signaling modulates pregnane x receptor activity in a species-specific manner

3 September 2018

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Pregnane X receptor is essential for normal progression of liver regeneration

3 September 2018

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Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer.

3 September 2018

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The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

3 September 2018

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3 September 2018

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Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents.

3 September 2018

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3 September 2018

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Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C.

3 September 2018

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mTOR and P70 S6 kinase expression in primary liver neoplasms

3 September 2018

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Gene regulation for the senescence marker protein DHEA-sulfotransferase by the xenobiotic-activated nuclear pregnane X receptor (PXR).

3 September 2018

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Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway

3 September 2018

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The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice

3 September 2018

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3 September 2018

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3 September 2018

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3 September 2018

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Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats

3 September 2018

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Expression and potential roles of pregnane X receptor in endometrial cancer

3 September 2018

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Altered expression and function of P-glycoprotein in dextran sodium sulfate-induced colitis in mice.

3 September 2018

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3 September 2018

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Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response

3 September 2018

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3 September 2018

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3 September 2018

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Role of nitric oxide in down-regulation of CYP2B1 protein, but not RNA, in primary cultures of rat hepatocytes

3 September 2018

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Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes

3 September 2018

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Hepatic and central nervous system cytochrome P450 are down-regulated during lipopolysaccharide-evoked localized inflammation in brain.

3 September 2018

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Negative regulation of the forkhead transcription factor FKHR by Akt.

3 September 2018

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Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis

3 September 2018

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Altered expression of hepatic CYP1A enzymes in rat hepatocarcinogenesis.

3 September 2018

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The Nature of Adverse Events in Hospitalized Patients

3 September 2018

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Inhibition of cytochrome P-450p (P450IIIA1) gene expression during liver regeneration from two-thirds hepatectomy in the rat

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Cytochrome P450 in livers of diabetic rats: regulation by growth hormone and insulin

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Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture

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12 December 2020

The enzymatic composition of rat liver microsomes during liver regeneration

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12 December 2020

The regulation of cytochrome P450 2E1 during LPS-induced inflammation in the rat

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12 December 2020

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12 December 2020

Suppression of the constitutive expression of cytochrome P-450 2C11 by cytokines and interferons in primary cultures of rat hepatocytes: comparison with induction of acute-phase genes and demonstration that CYP2C11 promoter sequences are involved in

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12 December 2020

Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture

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12 December 2020

Insulin suppresses the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes

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12 December 2020

Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture

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12 December 2020

Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytes in primary culture

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12 December 2020

Insulin-mediated modulation of cytochrome P450 gene induction profiles in primary rat hepatocyte cultures

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12 December 2020

Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer

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12 December 2020

Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved

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12 December 2020

10.1517/17425250903012360

Identifiers

DOI

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

19505191

1 reference