Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199 (Q34135298)

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21 March 2020

title

Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199 (English)

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21 March 2020

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lymphoblastic leukemia

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T-cell acute lymphoblastic leukemia

inferred from title

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3

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21 March 2020

Jeremy Ryan

4

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21 March 2020

15

Anthony Letai

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7

Mignon L Loh

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21 March 2020

author name string

Triona Ni Chonghaile

1

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21 March 2020

Justine E Roderick

2

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21 March 2020

Stephen E Sallan

5

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21 March 2020

Lewis B Silverman

6

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21 March 2020

Brent Wood

9

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21 March 2020

Daniel J DeAngelo

10

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21 March 2020

Richard Stone

11

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Marian Harris

12

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21 March 2020

Alejandro Gutierrez

13

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21 March 2020

Michelle A Kelliher

14

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21 March 2020

Stephen P Hunger

8

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21 March 2020

publication date

3 July 2014

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21 March 2020

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21 March 2020

volume

4

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issue

9

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21 March 2020

page(s)

1074-1087

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Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199.

21 March 2020

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Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia

5 July 2018

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BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines

5 July 2018

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ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia

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Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency

5 July 2018

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5 July 2018

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Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

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ETV6 mutations in early immature human T cell leukemias

5 July 2018

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Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy

5 July 2018

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Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia

5 July 2018

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Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.

5 July 2018

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The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs

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5 July 2018

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Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Bcl-XL and Bcl-2 repress a common pathway of cell death

5 July 2018

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5 July 2018

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Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations

5 July 2018

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New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling.

28 October 2018

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Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

28 October 2018

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28 October 2018

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bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation

28 October 2018

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12 December 2020

Acute lymphoblastic leukaemia

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12 December 2020

Antiapoptotic BCL-2 is required for maintenance of a model leukemia

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12 December 2020

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

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12 December 2020

10.1158/2159-8290.CD-14-0353

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24994123%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24994123%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

PubMed publication ID

24994123

1 reference