The genetic basis of fluconazole resistance development in Candida albicans (Q34135429)

31 July 2017

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title

The genetic basis of fluconazole resistance development in Candida albicans (English)

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31 July 2017

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1

Joachim Morschhäuser

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31 July 2017

language of work or name

English

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publication date

1 July 2002

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Biochimica et Biophysica Acta

31 July 2017

July 2002

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published in

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BBA: Molecular Basis of Disease

31 July 2017

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volume

1587

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31 July 2017

2-3

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31 July 2017

240-248

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Molecular genetic analysis of azole antifungal mode of action

31 July 2017

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Resistance of Candida species to fluconazole

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Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.

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Fluconazole susceptibility and strain variation of Candida albicans isolates from HIV-infected patients with oropharyngeal candidosis

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Multiple resistant phenotypes of Candida albicans coexist during episodes of oropharyngeal candidiasis in human immunodeficiency virus-infected patients

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7 January 2021

Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype.

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7 January 2021

Molecular aspects of fluconazole resistance development in Candida albicans

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7 January 2021

Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta5,6-desaturation

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7 January 2021

Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients

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Isolation and characterization of fluconazole- and amphotericin B-resistant Candida albicans from blood of two patients with leukemia

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7 January 2021

Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450

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7 January 2021

Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans.

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7 January 2021

Multiple amino acid substitutions in lanosterol 14alpha-demethylase contribute to azole resistance in Candida albicans.

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7 January 2021

Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains.

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Diethylcarbamazine-related antimicrobial activity in Mycobacterium tuberculosis-infected blood

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Genetic analysis of azole resistance in the Darlington strain of Candida albicans

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Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients

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The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity

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The R467K amino acid substitution in Candida albicans sterol 14alpha-demethylase causes drug resistance through reduced affinity.

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The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity

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7 January 2021

Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus

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In vitro and in vivo effects of 14alpha-demethylase (ERG11) depletion in Candida glabrata

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Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate

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Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene

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Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals

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Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

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Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors

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Sequential gene disruption in Candida albicans by FLP-mediated site-specific recombination.

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Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.

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The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter

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A fourth gene from the Candida albicans CDR family of ABC transporters

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A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole.

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7 January 2021

Inducible azole resistance associated with a heterogeneous phenotype in Candida albicans.

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Distinct patterns of gene expression associated with development of fluconazole resistance in serial candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis

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Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor

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AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily

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Isolation of a putative Candida albicans transcriptional regulator involved in pleiotropic drug resistance by functional complementation of a pdr1 pdr3 mutation in Saccharomyces cerevisiae

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7 January 2021

Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates.

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Multidrug resistance in Candida albicans: disruption of the BENr gene

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MDR1-mediated drug resistance in Candida dubliniensis

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Microbial fermentation-derived inhibitors of efflux-pump-mediated drug resistance

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Unusual susceptibility of a multidrug-resistant yeast strain to peptidic antifungals.

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Fluconazole versus Candida albicans: a complex relationship.

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Changes of virulence factors accompanying the phenomenon of induced fluconazole resistance in Candida albicans.

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Divergence in fitness and evolution of drug resistance in experimental populations of Candida albicans

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Decrease in Candida albicans strains with reduced susceptibility to fluconazole following changes in prescribing policies

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Resistance of Candida albicans biofilms to antifungal agents in vitro

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Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms

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Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance

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Isolation, characterization, and sequencing of Candida albicans repetitive element 2.

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7 January 2021

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Identifiers

DOI

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