Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. (Q34139532)

31 July 2017

title

Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. (English)

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31 July 2017

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Ellen Weisberg

1

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31 July 2017

Christina Boulton

2

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31 July 2017

Louise M Kelly

3

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31 July 2017

Paul Manley

4

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31 July 2017

Doriano Fabbro

5

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31 July 2017

Thomas Meyer

6

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31 July 2017

D Gary Gilliland

7

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31 July 2017

James D Griffin

8

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31 July 2017

publication date

1 June 2002

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31 July 2017

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31 July 2017

volume

1

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31 July 2017

issue

5

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31 July 2017

page(s)

433-443

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

31 July 2017

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Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells

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FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

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Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho)

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Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

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A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations

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Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia

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Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C.

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Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene

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Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

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Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor

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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

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In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor

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7 January 2021

10.1016/S1535-6108(02)00069-7

Identifiers

DOI

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31 July 2017

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