A sharp T-cell antigen receptor signaling threshold for T-cell proliferation (Q34144494)

25136127

31 July 2017

title

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation (English)

1 reference

31 July 2017

1

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4 June 2020

Julie Zikherman

2

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4 June 2020

Judith Ashouri

4

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4 June 2020

author name string

James L Mueller

3

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4 June 2020

Mehrdad Matloubian

5

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4 June 2020

Debra A Cheng

6

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4 June 2020

Yiling Chen

7

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4 June 2020

Kevan M Shokat

8

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4 June 2020

Arthur Weiss

9

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4 June 2020

language of work or name

English

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publication date

18 August 2014

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25136127

Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

published in

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4 June 2020

volume

111

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4 June 2020

issue

35

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4 June 2020

page(s)

E3679-88

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Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.

4 June 2020

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5 July 2018

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5 July 2018

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Endogenous antigen tunes the responsiveness of naive B cells but not T cells

5 July 2018

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5 July 2018

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T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

5 July 2018

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A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

5 July 2018

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5 July 2018

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Complete but curtailed T-cell response to very low-affinity antigen

5 July 2018

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Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling

5 July 2018

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Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

5 July 2018

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

5 July 2018

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Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response

5 July 2018

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Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response

5 July 2018

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Distinct temporal programming of naive CD4+ T cells for cell division versus TCR-dependent death susceptibility by antigen-presenting macrophages

5 July 2018

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T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

5 July 2018

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CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 Cytokine

5 July 2018

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A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Differential requirements for ZAP-70 in TCR signaling and T cell development

5 July 2018

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Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells

5 July 2018

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5 July 2018

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5 July 2018

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21 January 2018

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IL-2 secretion by CD4+ T cells in vivo is rapid, transient, and influenced by TCR-specific competition

21 January 2018

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21 January 2018

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Continuous T cell receptor signaling required for synapse maintenance and full effector potential

21 January 2018

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CD8 T cell expansion and memory differentiation are facilitated by simultaneous and sustained exposure to antigenic and inflammatory milieu.

21 January 2018

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Cutting edge: prolonged antigen presentation after herpes simplex virus-1 skin infection

21 January 2018

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21 January 2018

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21 January 2018

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Repeated antigen exposure is necessary for the differentiation, but not the initial proliferation, of naive CD4(+) T cells

28 October 2018

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12 December 2020

Continued antigen stimulation is not required during CD4(+) T cell clonal expansion

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12 December 2020

T cell fitness determined by signal strength

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12 December 2020

Dynamic programming of CD8+ T lymphocyte responses

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12 December 2020

Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling

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12 December 2020

The minimal number of antigen-major histocompatibility complex class II complexes required for activation of naive and primed T cells

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12 December 2020

Transcriptional analysis of clonal deletion in vivo

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12 December 2020

Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity

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12 December 2020

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1413726111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25136127%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

0 references

1 reference

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4 June 2020

25136127

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25136127%20AND%20SRC:MED&resulttype=core&format=json