Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling (Q39773899)

14 September 2017

title

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling (English)

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14 September 2017

author

Nicholas R J Gascoigne

9

object named as

Nicholas R J Gascoigne

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14 September 2017

Mark A Daniels

1

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14 September 2017

Emma Teixeiro

2

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14 September 2017

Jason Gill

3

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14 September 2017

Barbara Hausmann

4

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14 September 2017

Dominique Roubaty

5

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14 September 2017

Kaisa Holmberg

6

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14 September 2017

Guy Werlen

7

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14 September 2017

Georg A Holländer

8

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14 September 2017

Ed Palmer

10

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14 September 2017

language of work or name

English

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publication date

1 November 2006

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14 September 2017

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14 September 2017

volume

444

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14 September 2017

issue

7120

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14 September 2017

page(s)

724-729

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Positive and negative selection of T cells

14 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

The T cell receptor for antigen: signaling and ligand discrimination

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Positive and negative thymocyte selection induced by different concentrations of a single peptide

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Evidence for a differential avidity model of T cell selection in the thymus

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Central tolerance: learning self-control in the thymus

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Kinetic proofreading in T-cell receptor signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Mathematical and computational models of immune-receptor signalling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

T-cell-receptor affinity and thymocyte positive selection

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Ligand recognition by alpha beta T cell receptors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

T cell positive selection by a high density, low affinity ligand

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

T cell antigen-receptor signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

The Ras/MAPK cascade and the control of positive selection

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Signaling life and death in the thymus: timing is everything

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Negative selection--clearing out the bad apples from the T-cell repertoire

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

MEK activity regulates negative selection of immature CD4+CD8+ thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

MAP kinases in the immune response

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

T cell receptor antagonist peptides induce positive selection

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

A kinetic basis for T cell receptor repertoire selection during an immune response

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Subcellular localization determines MAP kinase signal output.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Compartmentalized Ras/MAPK signaling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

CD8 lineage commitment in the absence of CD8.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

In vitro models of T cell development

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https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

A requirement for sustained ERK signaling during thymocyte positive selection in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

T cell division and death are segregated by mutation of TCRbeta chain constant domains

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

T cell receptor-mediated signal transduction controlled by the beta chain transmembrane domain: apoptosis-deficient cells display unbalanced mitogen-activated protein kinases activities upon T cell receptor engagement.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05269

7 January 2021

Identifiers

DOI

10.1038/NATURE05269

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Dimensions Publication ID

14 September 2017

1051905835

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