The accessibility in the external part of the TM5 of the glutamate transporter EAAT1 is conformationally sensitive during the transport cycle (Q34146588)

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English	The accessibility in the external part of the TM5 of the glutamate transporter EAAT1 is conformationally sensitive during the transport cycle	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

The accessibility in the external part of the TM5 of the glutamate transporter EAAT1 is conformationally sensitive during the transport cycle (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

author name string

Xiuping Zhang

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Shaogang Qu

2

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Europe PubMed Central

PubMed publication ID

31 July 2017

language of work or name

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publication date

23 January 2012

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Europe PubMed Central

PubMed publication ID

31 July 2017

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Europe PubMed Central

PubMed publication ID

31 July 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

e30961

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

copyright license

Creative Commons Attribution 4.0 International

23 January 2012

1 reference

April 2022 Public Data File from Crossref

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Proximity of transmembrane segments 5 and 8 of the glutamate transporter GLT-1 inferred from paired cysteine mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

The 3-4 loop of an archaeal glutamate transporter homolog experiences ligand-induced structural changes and is essential for transport.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Time-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Substrates and non-transportable analogues induce structural rearrangements at the extracellular entrance of the glial glutamate transporter GLT-1/EAAT2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Dynamics of the extracellular gate and ion-substrate coupling in the glutamate transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Structure of a glutamate transporter homologue from Pyrococcus horikoshii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

A conserved serine-rich stretch in the glutamate transporter family forms a substrate-sensitive reentrant loop

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Structural features of the glutamate transporter family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Two serine residues of the glutamate transporter GLT-1 are crucial for coupling the fluxes of sodium and the neurotransmitter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Molecular determinant of ion selectivity of a (Na+ + K+)-coupled rat brain glutamate transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Flux coupling in a neuronal glutamate transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Expression of a cloned gamma-aminobutyric acid transporter in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Cloning and expression of a rat brain L-glutamate transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Primary structure and functional characterization of a high-affinity glutamate transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Active transport of L-glutamate by membrane vesicles isolated from rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264643

5 July 2018

Expression cloning of a rat glutamate transporter

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030961

21 January 2018

Biotinylation of single cysteine mutants of the glutamate transporter GLT-1 from rat brain reveals its unusual topology

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030961

21 January 2018

Coupled, but not uncoupled, fluxes in a neuronal glutamate transporter can be activated by lithium ions

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030961

21 January 2018

Cysteine scanning of the surroundings of an alkali-ion binding site of the glutamate transporter GLT-1 reveals a conformationally sensitive residue

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030961

21 January 2018

Proximity of two oppositely oriented reentrant loops in the glutamate transporter GLT-1 identified by paired cysteine mutagenesis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030961

21 January 2018

The accessibility of a novel reentrant loop of the glutamate transporter GLT-1 is restricted by its substrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22292083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of arginine 44 of GAT-1, a (Na(+) + Cl(-))-coupled gamma-aminobutyric acid transporter from rat brain, impairs net flux but not exchange

1 reference

https://pubmed.ncbi.nlm.nih.gov/22292083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/22292083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A reentrant loop domain in the glutamate carrier EAAT1 participates in substrate binding and translocation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22292083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple consequences of mutating two conserved beta-bridge forming residues in the translocation cycle of a neuronal glutamate transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/22292083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glutamate and chloride permeation pathways are colocalized in individual neuronal glutamate transporter subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/22292083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rigidity of the subunit interfaces of the trimeric glutamate transporter GltT during translocation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22292083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of an amino acid residue influencing potassium coupling in the glutamate transporter GLT-1 induces obligate exchange

1 reference

https://pubmed.ncbi.nlm.nih.gov/22292083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0030961

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

2012PLoSO...730961Z

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ResearchGate publication ID

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