Synthetic lethality: General principles, utility and detection using genetic screens in human cells (Q34151015)

31 July 2017

1 reference

8 February 2021

Synthetic lethality: general principles, utility and detection using genetic screens in human cells (English)

1 reference

31 July 2017

Synthetic lethality: General principles, utility and detection using genetic screens in human cells (English)

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2010.11.024

31 August 2024

main subject

gene regulatory network

1 reference

5 September 2020

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6 November 2020

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8 February 2021

1

Sebastian M. B. Nijman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21094158

31 August 2024

language of work or name

English

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publication date

19 November 2010

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full work available at URL

31 July 2017

3 January 2011

7 references

3 April 2019

20 June 2019

30 June 2019

14 September 2019

5 September 2020

6 November 2020

8 February 2021

https://doi.org/10.1016/j.febslet.2010.11.024

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21094158

https://europepmc.org/articles/PMC3018572

31 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21094158

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.febslet.2010.11.024

31 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2010.11.024

http://onlinelibrary.wiley.com/wol1/doi/10.1016/j.febslet.2010.11.024/fullpdf

31 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2010.11.024

31 August 2024

8 references

31 July 2017

3 April 2019

20 June 2019

30 June 2019

14 September 2019

5 September 2020

6 November 2020

8 February 2021

585

1 reference

31 July 2017

issue

1

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31 July 2017

page(s)

1-6

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

31 July 2017

copyright license

7 references

3 April 2019

20 June 2019

30 June 2019

14 September 2019

5 September 2020

6 November 2020

on focus list of Wikimedia project

8 February 2021

ScienceSource

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cites work

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Synthetic lethality: a framework for the development of wiser cancer therapeutics

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Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma

5 July 2018

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5 July 2018

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Systematic mapping of genetic interaction networks

5 July 2018

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

5 July 2018

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Synthetic lethality--a new direction in cancer-drug development

5 July 2018

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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

5 July 2018

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Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

5 July 2018

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Functional organization of the S. cerevisiae phosphorylation network

5 July 2018

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Principles of cancer therapy: oncogene and non-oncogene addiction

5 July 2018

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Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.

5 July 2018

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Decanalization and the origin of complex disease

5 July 2018

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Highly parallel identification of essential genes in cancer cells

5 July 2018

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Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells

5 July 2018

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Combination chemical genetics

5 July 2018

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Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes

5 July 2018

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Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

5 July 2018

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Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota

5 July 2018

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Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast

5 July 2018

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5 July 2018

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A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair

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5 July 2018

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A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Synthetic lethal screen identification of chemosensitizer loci in cancer cells

5 July 2018

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Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions

5 July 2018

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Multi-target therapeutics: when the whole is greater than the sum of the parts

5 July 2018

1 reference

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RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival

5 July 2018

1 reference

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The NCI60 human tumour cell line anticancer drug screen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

A loss-of-function RNA interference screen for molecular targets in cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

HSP90 and the chaperoning of cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

The concept of synthetic lethality in the context of anticancer therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

Combining biological networks to predict genetic interactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

Cancer. Addiction to oncogenes--the Achilles heal of cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

Use of isogenic human cancer cells for high-throughput screening and drug discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

Principles for the buffering of genetic variation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

Hsp90 as a capacitor for morphological evolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

Integrating genetic approaches into the discovery of anticancer drugs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways

5 July 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.11.024

Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.11.024

Evolutionary plasticity of genetic interaction networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.11.024

Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.11.024

Genetics of natural populations; recombination and variability in populations of Drosophila pseudoobscura

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018572

28 October 2018

Identifiers

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release_rjug7tiisbgqvlp5hj4ykmng5m

31 July 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/rjug7tiisbgqvlp5hj4ykmng5m

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

3018572

1 reference

31 July 2017

1 reference