The double life of a B-1 cell: self-reactivity selects for protective effector functions (Q34154602)

31 July 2017

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title

The double life of a B-1 cell: self-reactivity selects for protective effector functions (English)

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31 July 2017

Nicole Baumgarth

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31 July 2017

10 December 2010

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Nature Reviews Immunology

31 July 2017

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31 July 2017

11

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31 July 2017

34-46

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31 July 2017

1

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Serum immunoglobulin levels and naturally occurring antibodies against carbohydrate antigens in germ-free BALB/c mice fed chemically defined ultrafiltered diet

31 July 2017

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The repertoire of serum IgM in normal mice is largely independent of external antigenic contact

31 March 2020

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Isotypes and specificities of immunoglobulins produced by germ-free mice fed chemically defined ultrafiltered “antigen-free” diet

31 March 2020

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Induction of immunoglobulin and antibody synthesisin vitro by lipopolysaccharides

31 March 2020

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Mechanism of B-cell activation and paralysis by thymus-independent antigens. Additive effects between NNP-LPS and LPS in the specific response to the hapten

31 March 2020

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Innate pathways to B-cell activation and tolerance

31 March 2020

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Toll-like receptors--sentries in the B-cell response

31 March 2020

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B cell autonomous TLR signaling and autoimmunity

31 March 2020

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Antigen receptor proximal signaling in splenic B-2 cell subsets

31 March 2020

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Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion

31 March 2020

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Immunoglobulins did not arise in evolution to fight infection

31 March 2020

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Natural antibodies and the autoimmunity of atherosclerosis.

31 March 2020

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Role of B-1a cells in autoimmunity

31 March 2020

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B-1 B cells: development, selection, natural autoantibody and leukemia

31 March 2020

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The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice

31 March 2020

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Progenitors for Ly-1 B cells are distinct from progenitors for other B cells

31 March 2020

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Differential development of progenitor activity for three B-cell lineages

31 March 2020

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The development and repertoire of B-1 cells (CD5 B cells)

31 March 2020

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Para-aortic splanchnopleura from early mouse embryos contains B1a cell progenitors

31 March 2020

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Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation

31 March 2020

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A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses

31 March 2020

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Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells

31 March 2020

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Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens

31 March 2020

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Origins and functions of B-1 cells with notes on the role of CD5

31 March 2020

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Fetal B-cell lymphopoiesis and the emergence of B-1-cell potential.

31 March 2020

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Feedback regulation of murine Ly-1 B cell development

31 March 2020

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Murine peritoneal Ly-1 B cells do not turn over rapidly

31 March 2020

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Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system

31 March 2020

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Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells.

31 March 2020

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Adult BM generates CD5+ B1 cells containing abundant N-region additions

31 March 2020

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Identification of a B-1 B cell-specified progenitor.

31 March 2020

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B-1a, B-1b and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressures.

31 March 2020

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Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation

31 March 2020

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Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans

31 March 2020

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Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury

31 March 2020

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IgM in microbial infections: taken for granted?

31 March 2020

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Receptor Sensitivity: When T cells Lose Their Sense of Self

31 March 2020

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Positive selection of natural autoreactive B cells

31 March 2020

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B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development.

31 March 2020

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B cell receptor signal strength determines B cell fate.

31 March 2020

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A differentiation pathway for B1 cells in adult bone marrow

31 March 2020

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Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development

31 March 2020

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Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population

31 March 2020

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The role of IL-5 for mature B-1 cells in homeostatic proliferation, cell survival, and Ig production

31 March 2020

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Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells

31 March 2020

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CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity

31 March 2020

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B-1a B cells that link the innate and adaptive immune responses are lacking in the absence of the spleen

31 March 2020

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Evaluation of intranuclear BrdU detection procedures for use in multicolor flow cytometry

31 March 2020

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Maintenance of peritoneal B-1a lymphocytes in the absence of the spleen.

31 March 2020

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Spontaneously Ig-secreting B-1 cells violate the accepted paradigm for expression of differentiation-associated transcription factors

31 March 2020

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Different kinetics of blimp-1 induction in B cell subsets revealed by reporter gene.

31 March 2020

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B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion

31 March 2020

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Dual role for B-1a cells in immunity to influenza virus infection

31 March 2020

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B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection

31 March 2020

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A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection

31 March 2020

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B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae

31 March 2020

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Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity

31 March 2020

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Control of early viral and bacterial distribution and disease by natural antibodies

31 March 2020

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The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies

31 March 2020

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A two-phase model of B-cell activation

31 March 2020

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Roles of B-1 and B-2 cells in innate and acquired IgA-mediated immunity

31 March 2020

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Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells

31 March 2020

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B1 and B2 cells differ in their potential to switch immunoglobulin isotype.

31 March 2020

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B1 Cells Contribute to Serum IgM, But Not to Intestinal IgA, Production in Gnotobiotic Ig Allotype Chimeric Mice

31 March 2020

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Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity

31 March 2020

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B-1 cells and their reactivity with the murine intestinal microflora

31 March 2020

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The functional interactions of commensal bacteria with intestinal secretory IgA.

31 March 2020

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B-1 cells modulate oral tolerance in mice

31 March 2020

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Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM.

31 March 2020

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Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity

31 March 2020

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IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells

31 March 2020

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Macrophage receptors and immune recognition

31 March 2020

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T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice

31 March 2020

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Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10.

31 March 2020

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Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll-like receptors in immunity.

31 March 2020

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Regulation of B1 cell migration by signals through Toll-like receptors

31 March 2020

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Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse

31 March 2020

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Administration of interleukin-5 or -10 activates peritoneal B-1 cells and induces autoimmune hemolytic anemia in anti-erythrocyte autoantibody-transgenic mice

31 March 2020

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Division and differentiation of natural antibody-producing cells in mouse spleen

31 March 2020

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TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses

31 March 2020

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The unique antigen receptor signaling phenotype of B-1 cells is influenced by locale but induced by antigen

31 March 2020

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Abnormal transcription factor induction through the surface immunoglobulin M receptor of B-1 lymphocytes

31 March 2020

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CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells

31 March 2020

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Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity

31 March 2020

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Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cells

31 March 2020

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Defective CD19-dependent signaling in B-1a and B-1b B lymphocyte subpopulations

31 March 2020

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Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck.

31 March 2020

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Normal B-1 cell development but defective BCR signaling in Lck-/- mice

31 March 2020

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B-1 cells are deficient in Lck: defective B cell receptor signal transduction in B-1 cells occurs in the absence of elevated Lck expression

31 March 2020

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Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population

31 March 2020

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Peritoneal CD5+ B-1 cells have signaling properties similar to tolerant B cells

31 March 2020

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CD5 maintains tolerance in anergic B cells

31 March 2020

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A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes.

31 March 2020

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Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy

31 March 2020

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Reduced life span of anergic self-reactive B cells in a double-transgenic model

31 March 2020

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Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses

31 March 2020

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Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge

31 March 2020

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B1b lymphocytes confer T cell-independent long-lasting immunity

31 March 2020

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Mac-1-negative B-1b phenotype of natural antibody-producing cells, including those responding to Gal alpha 1,3Gal epitopes in alpha 1,3-galactosyltransferase-deficient mice

31 March 2020

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Extravascular T-cell recruitment requires initiation begun by Valpha14+ NKT cells and B-1 B cells

31 March 2020

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Identification of initiator B cells, a novel subset of activation-induced deaminase-dependent B-1-like cells that mediate initiation of contact sensitivity

31 March 2020

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Natural killer T cells and innate immune B cells from lupus-prone NZB/W mice interact to generate IgM and IgG autoantibodies

31 March 2020

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Migration and differentiation of autoreactive B-1 cells induced by activated gamma/delta T cells in antierythrocyte immunoglobulin transgenic mice

31 March 2020

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Identification of the target self-antigens in reperfusion injury

31 March 2020

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The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response

31 March 2020

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Enhanced trafficking to the pancreatic lymph nodes and auto-antigen presentation capacity distinguishes peritoneal B lymphocytes in non-obese diabetic mice

31 March 2020

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Mls presentation by peritoneal cavity B cells

31 March 2020

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B1 cells promote pancreas infiltration by autoreactive T cells.

31 March 2020

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Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs.

31 March 2020

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Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset

31 March 2020

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Rheumatoid factor secretion from human Leu-1+ B cells.

31 March 2020

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Autoimmunity-prone B-1 (CD5 B) cells, natural antibodies and self recognition

31 March 2020

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Characterization of cells of the B lineage in the human adult greater omentum.

31 March 2020

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CD19+CD5+ B cells in primary IgA nephropathy.

31 March 2020

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CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients

31 March 2020

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Peripheral development of B cells in mouse and man.

31 March 2020

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Identification and characterization of a human CD5+ pre-naive B cell population

31 March 2020

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31 March 2020

Marginal zone B cells

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Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

31 March 2020

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Impairment of the antipolysaccharide response in splenectomized patients is due to the lack of immunoglobulin M memory B cells.

31 March 2020

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Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants

31 March 2020

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A checkpoint for autoreactivity in human IgM+ memory B cell development

31 March 2020

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Predominant autoantibody production by early human B cell precursors

31 March 2020

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Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells.

31 March 2020

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Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells

31 March 2020

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Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

31 March 2020

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B-cell immunophenotyping.

31 March 2020

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A practical approach to multicolor flow cytometry for immunophenotyping

31 March 2020

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CD11b expression distinguishes sequential stages of peritoneal B-1 development

31 March 2020

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CD5+/Mac-1- peritoneal B cells: a novel B cell subset that exhibits characteristics of B-1 cells

31 March 2020

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Treatment of murine CD5- B cells with anti-Ig, but not LPS, induces surface CD5: two B-cell activation pathways.

31 March 2020

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Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor alpha chain expression on activated B cells.

31 March 2020

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CD9 is a unique marker for marginal zone B cells, B1 cells, and plasma cells in mice.

31 March 2020

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31 March 2020

Marginal-zone B cells

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Origin of murine B cell lineages

31 March 2020

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Regulatory B cells as inhibitors of immune responses and inflammation

31 March 2020

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The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals

31 March 2020

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Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow

31 March 2020

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Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells

31 March 2020

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From the fetal liver to spleen and gut: the highway to natural antibody.

31 March 2020

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Unique properties of memory B cells of different isotypes

31 March 2020

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Ontogeny of terminal deoxynucleotidyl transferase-positive cells in lymphohemopoietic tissues of rat and mouse

31 March 2020

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12 December 2020

B-1 cells: the lineage question revisited

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12 December 2020

From natural polyreactive autoantibodies to à la carte monoreactive antibodies to infectious agents: is it a small world after all?

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12 December 2020

Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM

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12 December 2020

CD5+ peritoneal B cells express high levels of membrane, but not secretory, C mu mRNA

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12 December 2020

Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands.

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12 December 2020

Identification and analysis of a novel human surface CD5- B lymphocyte subset producing natural antibodies

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12 December 2020

CD43 (S7) expression identifies peripheral B cell subsets

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12 December 2020

B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a "natural immune memory".

1 reference

12 December 2020

An unbiased analysis of V(H)-D-J(H) sequences from B-1a, B-1b, and conventional B cells.

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12 December 2020

Identifiers

DOI

10.1038/NRI2901

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31 July 2017

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PubMed ID

21151033