Potential roles of antisense oligonucleotides in cancer therapy. The example of Bcl-2 antisense oligonucleotides (Q34160291)

31 July 2017

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title

Potential roles of antisense oligonucleotides in cancer therapy. The example of Bcl-2 antisense oligonucleotides (English)

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31 July 2017

Nathalie Dias

1

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PubMed ID

12445555

31 July 2017

C A Stein

series ordinal

2

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PubMed ID

12445555

31 July 2017

language of work or name

English

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publication date

1 November 2002

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European Journal of Pharmaceutics and Biopharmaceutics

31 July 2017

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31 July 2017

54

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31 July 2017

3

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31 July 2017

263-269

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Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

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A simple method for delivering morpholino antisense oligos into the cytoplasm of cells

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Electroporation enhances c-myc antisense oligodeoxynucleotide efficacy

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An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers

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Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo

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Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression

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Selecting optimal oligonucleotide composition for maximal antisense effect following streptolysin O-mediated delivery into human leukaemia cells

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Multiple mechanisms may contribute to the cellular anti-adhesive effects of phosphorothioate oligodeoxynucleotides.

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Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix

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Increased specificity for antisense oligodeoxynucleotide targeting of RNA cleavage by RNase H using chimeric methylphosphonodiester/phosphodiester structures

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RNase H-mediated inhibition of translation by antisense oligodeoxyribonucleotides: use of backbone modification to improve specificity

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2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

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Pattern and kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice

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Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides

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Effect of different chemically modified oligodeoxynucleotides on immune stimulation

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Dynamics of the internalization of phosphodiester oligodeoxynucleotides in HL60 cells

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In vitro transport and delivery of antisense oligonucleotides

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Cell-specific optimization of phosphorothioate antisense oligodeoxynucleotide delivery by cationic lipids

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Mechanism of oligonucleotide release from cationic liposomes

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Programmable fusogenic vesicles for intracellular delivery of antisense oligodeoxynucleotides: enhanced cellular uptake and biological effects

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Development of efficient transient transfection systems for introducing antisense oligonucleotides into human epithelial skin cells

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Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers

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Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles

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Inhibition of hepadnaviral replication by polyethylenimine-based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver

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Protamine-fragment peptides fused to an SV40 nuclear localization signal deliver oligonucleotides that produce antisense effects in prostate and bladder carcinoma cells

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Trojan peptides: the penetratin system for intracellular delivery.

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Life-or-death decisions by the Bcl-2 protein family.

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

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BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense

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Regulation of chemoresistance by the bcl-2 oncoprotein in non-Hodgkin's lymphoma and lymphocytic leukemia cell lines

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Investigations of antisense oligonucleotides targeted against bcl-2 RNAs.

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Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression.

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Bcl-2 and bcl-xL antisense oligonucleotides induce apoptosis in melanoma cells of different clinical stages

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BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

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Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma

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bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

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Bcl-2 antisense oligonucleotides chemosensitize human gastric cancer in a SCID mouse xenotransplantation model

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Synergistic chemosensitization and inhibition of progression to androgen independence by antisense Bcl-2 oligodeoxynucleotide and paclitaxel in the LNCaP prostate tumor model

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Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines

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7 January 2021

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

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7 January 2021

10.1016/S0939-6411(02)00060-7

Identifiers

DOI

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31 July 2017

1 reference

PubMed ID

12445555