Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity (Q34161517)

31 July 2017

Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity (English)

1 reference

31 July 2017

1 reference

1 reference

Wenzhong Guo

1

1 reference

31 July 2017

Diana Smith

2

1 reference

31 July 2017

Katja Aviszus

3

1 reference

31 July 2017

Thiago Detanico

4

1 reference

31 July 2017

Ryan A Heiser

5

1 reference

31 July 2017

Lawrence J Wysocki

6

1 reference

31 July 2017

language of work or name

English

0 references

publication date

30 August 2010

1 reference

Journal of Experimental Medicine

31 July 2017

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31 July 2017

207

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31 July 2017

2225-2237

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31 July 2017

10

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Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

31 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Sites and stages of autoreactive B cell activation and regulation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Autoreactivity in human IgG+ memory B cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

VH replacement in mice and humans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Receptor editing in lymphocyte development and central tolerance.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Complete sequence assembly and characterization of the C57BL/6 mouse Ig heavy chain V region

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Early preplasma cells define a tolerance checkpoint for autoreactive B cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

The evolution of human anti-double-stranded DNA autoantibodies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Cellular and genetic mechanisms of self tolerance and autoimmunity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Chromatin specificity of anti-double-stranded DNA antibodies and a role for Arg residues in the third complementarity-determining region of the heavy chain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Autoreactive B cells in the marginal zone that express dual receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Crystal structure of an antigen-binding fragment bound to single-stranded DNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Amino acid-base interactions: a three-dimensional analysis of protein-DNA interactions at an atomic level

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

The importance of somatic mutations in the V(lambda) gene 2a2 in human monoclonal anti-DNA antibodies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain complementarity-determining region 3 Arg in binding of double- and single-stranded DNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Directed evolution of green fluorescent protein by a new versatile PCR strategy for site-directed and semi-random mutagenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Terminal deoxynucleotidyl transferase deficiency reduces the incidence of autoimmune nephritis in (New Zealand Black x New Zealand White)F1 mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Residues that mediate DNA binding of autoimmune antibodies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Receptor editing: an approach by autoreactive B cells to escape tolerance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Receptor editing in self-reactive bone marrow B cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Mice lacking TdT: mature animals with an immature lymphocyte repertoire

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Effect of heavy chain signal peptide mutations and NH2-terminal chain length on binding of anti-digoxin antibodies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Genetic and structural evidence for antigen selection of anti-DNA antibodies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

kappa+lambda+ dual receptor B cells are present in the human peripheral repertoire

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Somatic evolution of variable region structures during an immune response

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Molecular analysis of original antigenic sin. I. Clonal selection, somatic mutation, and isotype switching during a memory B cell response

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Structural studies of protein-nucleic acid interaction: the sources of sequence-specific binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Intraclonal generation of antibody mutants in germinal centres

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Increased frequency of both total and specific monoclonal antibody producing hybridomas using a fusion partner that constitutively expresses recombinant IL-6.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Assembly and analysis of the mouse immunoglobulin kappa gene sequence.

5 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092712

Specificity-based negative selection of autoreactive B cells during memory formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092712

Somatic mutations to arginine residues affect the binding of human monoclonal antibodies to DNA, histones, SmD and Ro antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092712

Bcl-2 obstructs negative selection of autoreactive, hypermutated antibody V regions during memory B cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092712

Functional and modelling studies of the binding of human monoclonal anti-DNA antibodies to DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092712

Codon bias and plasticity in immunoglobulins

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092712

Dual isotype expressing B cells [kappa(+)/lambda(+)] arise during the ontogeny of B cells in the bone marrow of normal nontransgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092712

Tolerance to DNA in (NZB x NZW)F1 mice that inherit an anti-DNA V(H) as a conventional micro H chain transgene but not as a V(H) knock-in transgene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092712

Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092712

A receptor presentation hypothesis for T cell help that recruits autoreactive B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092712

Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodies.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

The mechanism of autoantibody production in an autoimmune MRL/lpr mouse.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947070

The structural basis for DNA binding by an anti-DNA autoantibody

28 October 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092712

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092712

The role of clonal selection and somatic mutation in autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092712

The in vivo and in vitro glomerular deposition of isolated anti-double-stranded-DNA antibodies in NZB/W mice

21 January 2018

1 reference

12 December 2020

Murine models of systemic lupus erythematosus

1 reference

12 December 2020

Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice

1 reference

12 December 2020

Selection of anti-double-stranded DNA B cells in autoimmune MRL-lpr/lpr mice

1 reference

12 December 2020

Structural patterns in anti-DNA antibodies from MRL/lpr mice

1 reference

12 December 2020

Somatic mutations in antibodies expressed by germinal centre B cells early after primary immunization

1 reference

12 December 2020

Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus

1 reference

12 December 2020

Evolution of Ig DNA sequence to target specific base positions within codons for somatic hypermutation

1 reference

12 December 2020

Evolution of autoantibody responses via somatic hypermutation outside of germinal centers

1 reference

12 December 2020

Dominant, hierarchical induction of peripheral tolerance during foreign antigen-driven B cell development

1 reference

12 December 2020

Effect of genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production and renal disease in MRL/lpr mice

1 reference

12 December 2020

Autoimmune NZB/NZW F1 mice utilize B cell receptor editing for generating high-affinity anti-dsDNA autoantibodies from low-affinity precursors

1 reference

12 December 2020

Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus. Comparison of antibodies in serum and renal eluates

1 reference

12 December 2020

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1 reference

12 December 2020

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20092712

1 reference

31 July 2017

1 reference

31 July 2017

1 reference