Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models (Q34162785)

31 July 2017

Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models (English)

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31 July 2017

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Rosalind J Jackson

1

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31 July 2017

Jalila Adnane

2

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31 July 2017

Domenico Coppola

3

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31 July 2017

Alan Cantor

4

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31 July 2017

Saïd M Sebti

5

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31 July 2017

W Jock Pledger

6

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31 July 2017

language of work or name

English

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publication date

1 December 2002

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31 July 2017

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31 July 2017

21

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31 July 2017

55

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31 July 2017

8486-8497

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205946

31 July 2017

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cites work

Transgenic models of tumor development.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Repression of p27kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Radiation-induced cell cycle arrest compromised by p21 deficiency

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

49 Rapid DNA isolations for enzymatic and hybridization analysis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Integration of positive and negative growth signals during ras pathway activation in vivo

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Cyclins and cell cycle checkpoints

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Ras effectors and their role in mitogenesis and oncogenesis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Role of p27Kip1 and cyclin-dependent kinase 2 in the proliferation of non-small cell lung cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Activation of ras oncogenes preceding the onset of neoplasia.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

The carcinogenic action and metabolism of urethan and N-hydroxyurethan

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Specific Ki-ras codon 61 mutations may determine the development of urethan-induced mouse lung adenomas or adenocarcinomas.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

p27(Kip1) is an inducer of intestinal epithelial cell differentiation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Inhibitors of mammalian G1 cyclin-dependent kinases

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

p21WAF1 mutations and human malignancies

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F 1 hybrids

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

p53 function and dysfunction

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Loss of p21CIP1/WAF1 does not recapitulate accelerated malignant conversion caused by p53 loss in experimental skin carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3 F1 mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Prognostic impact of p21/waf1/cip1 in colorectal cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205946

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205946

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Dimensions Publication ID

31 July 2017

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1 reference