Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain (Q34189079)

31 July 2017

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain (English)

1 reference

31 July 2017

protein ubiquitination

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Melanie A McGill

1

1 reference

PubMed ID

12682059

31 July 2017

C Jane McGlade

series ordinal

2

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PubMed ID

12682059

31 July 2017

language of work or name

English

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publication date

7 April 2003

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Journal of Biological Chemistry

31 July 2017

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31 July 2017

278

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31 July 2017

25

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31 July 2017

23196-23203

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Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

31 July 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Numb antagonizes Notch signaling to specify sibling neuron cell fates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Asymmetric segregation of Numb and Prospero during cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Mouse numb is an essential gene involved in cortical neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Multiple roles of mouse Numb in tuning developmental cell fates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Arbiter of differentiation and death: Notch signaling meets apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Involvement of Notch1 in the development of mouse mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Notch signalling pathway and human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The Notch pathway: democracy and aristocracy in the selection of cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The Notch1 receptor is cleaved constitutively by a furin-like convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Nuclear access and action of notch in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Protein degradation: four E3s for the notch pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

RING finger proteins: mediators of ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The Mdm2 oncoprotein interacts with the cell fate regulator Numb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Siah-1 binds and regulates the function of Numb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Calcium depletion dissociates and activates heterodimeric notch receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Dominant-negative mutation in the beta2 and beta6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Numb is an endocytic protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

21 January 2018

Identifiers

DOI

10.1074/JBC.M302827200

1 reference

31 July 2017

1 reference

PubMed ID

12682059