The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras (Q34189442)

31 July 2017

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras (English)

1 reference

31 July 2017

Jose Luis Oliva

1

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31 July 2017

Dolores Pérez-Sala

2

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31 July 2017

Antonio Castrillo

3

1 reference

31 July 2017

Natalia Martínez

4

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31 July 2017

F Javier Cañada

5

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31 July 2017

Lisardo Boscá

6

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31 July 2017

José M Rojas

7

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31 July 2017

language of work or name

English

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publication date

8 April 2003

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31 July 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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31 July 2017

100

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31 July 2017

8

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31 July 2017

4772-4777

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15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis

31 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Differential activation of the Rac pathway by Ha-Ras and K-Ras

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgamma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

The isoform-specific stretch of hSos1 defines a new Grb2-binding domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Understanding Ras: 'it ain't over 'til it's over'.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Delta(12,14)-prostaglandin J(2) in activated murine macrophages

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Novel aspects of Ras proteins biology: regulation and implications.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Isoform-specific insertion near the Grb2-binding domain modulates the intrinsic guanine nucleotide exchange activity of hSos1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Potent prostaglandin A1 analogs that suppress tumor cell growth through induction of p21 and reduction of cyclin E.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Rho GTPases and the actin cytoskeleton

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Antiviral activity of cyclopentenone prostanoids

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Inhibition of nuclear factor kappa B by prostaglandin A1: an effect associated with heat shock transcription factor activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

A 15 amino acid stretch close to the Grb2-binding domain defines two differentially expressed hSos1 isoforms with markedly different Grb2 binding affinity and biological activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Organic synthesis of prostaglandins: advancing biology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

The murine N-ras gene is not essential for growth and development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Differential expression of the ras gene family in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Occurrence of 9-deoxy-delta 9,delta 12-13,14-dihydroprostaglandin D2 in human urine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153631

Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

Cell cycle-dependent activation of Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

Multiple ras effector pathways contribute to G(1) cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

Structural and Functional Analysis of a Mutant Ras Protein That Is Insensitive to Nitric Oxide Activation†

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

Prostaglandin A2 and delta 12-prostaglandin J2 induce apoptosis in L1210 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

Inducible cyclooxygenase may have anti-inflammatory properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

Ras--a versatile cellular switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

K-ras is essential for the development of the mouse embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0735842100

Prostaglandin A2 protein interactions and inhibition of cellular proliferation

21 January 2018

1 reference

12 December 2020

Compartmentalization of Ras proteins

1 reference

12 December 2020

Antitumor activity of delta 7-prostaglandin A1 and delta 12-prostaglandin J2 in vitro and in vivo

1 reference

12 December 2020

Alterations of MCF-7 human breast cancer cell after prostaglandins PGA1 and PGF2 alpha treatment

1 reference

12 December 2020

Site and mechanism of growth inhibition by prostaglandins. III. Distribution and binding of prostaglandin A2 and delta 12-prostaglandin J2 in nuclei

1 reference

12 December 2020

Expression of ras proto-oncogene proteins in normal human tissues

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0735842100

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31 July 2017

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31 July 2017

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