Presenilin and gamma-secretase: structure meets function (Q34190156)

31 July 2017

1 reference

title

Presenilin and gamma-secretase: structure meets function (English)

1 reference

31 July 2017

Wolfe MS

1

1 reference

PubMed ID

11259478

31 July 2017

language of work or name

English

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publication date

1 March 2001

1 reference

Journal of Neurochemistry

31 July 2017

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31 July 2017

76

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31 July 2017

6

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31 July 2017

1615-1620

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Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

31 July 2017

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Alzheimer's disease. A firm base for drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

The Alzheimer family of diseases: many etiologies, one pathogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Evidence for a six-transmembrane domain structure of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

The Notch1 receptor is cleaved constitutively by a furin-like convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

In search of gamma-secretase: presenilin at the cutting edge

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00245.X

10.1046/J.1471-4159.2001.00245.X

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11259478