Ocular neuroprotection by siRNA targeting caspase-2 (Q34192944)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21677688%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Ocular neuroprotection by siRNA targeting caspase-2 (English)

1 reference

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5 February 2020

15

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5 February 2020

author name string

Z Ahmed

1

1 reference

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5 February 2020

H Kalinski

2

1 reference

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5 February 2020

M Berry

3

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5 February 2020

M Almasieh

4

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5 February 2020

H Ashush

5

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5 February 2020

N Slager

6

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5 February 2020

A Brafman

7

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5 February 2020

I Spivak

8

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5 February 2020

N Prasad

9

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5 February 2020

I Mett

10

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5 February 2020

E Shalom

11

1 reference

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5 February 2020

E Alpert

12

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5 February 2020

A Di Polo

13

1 reference

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5 February 2020

E Feinstein

14

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5 February 2020

publication date

16 June 2011

1 reference

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5 February 2020

published in

Cell Death and Disease

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5 February 2020

volume

2

1 reference

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5 February 2020

page(s)

e173

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Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?

5 February 2020

cites work

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Retinal ganglion cell death postponed: giving apoptosis a break?

5 July 2018

1 reference

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Characterization of cytoplasmic caspase-2 activation by induced proximity.

5 July 2018

1 reference

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Non-arteritic anterior ischaemic optic neuropathy: a review and update

5 July 2018

1 reference

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siRNA and innate immunity

5 July 2018

1 reference

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Caspase-2 activation in the absence of PIDDosome formation

5 July 2018

1 reference

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Neurodegenerative diseases of the retina and potential for protection and recovery

5 July 2018

1 reference

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Neurotrophin roles in retinal ganglion cell survival: lessons from rat glaucoma models

5 July 2018

1 reference

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The enigma of caspase-2: the laymen's view

5 July 2018

1 reference

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The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats

5 July 2018

1 reference

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Time course profiling of the retinal transcriptome after optic nerve transection and optic nerve crush

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Induction of the interferon response by siRNA is cell type- and duplex length-dependent

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Real-time quantification of microRNAs by stem-loop RT-PCR

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Intraocular delivery of oligonucleotides.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

The biochemical mechanism of caspase-2 activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Gene therapy for proliferative ocular diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Challenges and strategies: the immune responses in gene therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Activation of the interferon system by short-interfering RNAs

5 July 2018

1 reference

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Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

5 July 2018

1 reference

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Apoptosis. A cinderella caspase takes center stage

5 July 2018

1 reference

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TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo.

5 July 2018

1 reference

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Involvement of caspase-2 long isoform in Fas-mediated cell death of human leukemic cells.

5 July 2018

1 reference

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Short communication: protection of axotomized retinal ganglion cells by adenovirally delivered BDNF in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Effects of GDNF on retinal ganglion cell survival following axotomy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

YVAD protect post-natal retinal ganglion cells against axotomy-induced but not free radical-induced axonal degeneration in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Processing of the Nedd2 precursor by ICE-like proteases and granzyme B.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

RAIDD is a new 'death' adaptor molecule

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Non-arteritic anterior ischemic optic neuropathy and refraction.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats

5 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.54

Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.54

Caspase-2 is required for cell death induced by cytoskeletal disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.54

In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.54

DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.54

Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.54

Optic nerve regeneration after intravitreal peripheral nerve implants: trajectories of axons regrowing through the optic chiasm into the optic tracts

21 January 2018

1 reference

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Schwann cell-derived factor-induced modulation of the NgR/p75NTR/EGFR axis disinhibits axon growth through CNS myelin in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.54

Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.54

Neurotrophic factor synergy is required for neuronal survival and disinhibited axon regeneration after CNS injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.54

Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.54

Virology and immunology of gene therapy, or virology and immunology of high MOI infection with defective viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.54

Caspase-2: vestigial remnant or master regulator?

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3168996

Induction of an interferon response by RNAi vectors in mammalian cells

28 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.54

Protection of retinal ganglion cells and preservation of function after optic nerve lesion in bcl-2 transgenic mice

21 January 2018

1 reference

12 December 2020

Transplantation of activated macrophages overcomes central nervous system regrowth failure

1 reference

12 December 2020

BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia

1 reference

12 December 2020

Co-expression of AMPA/kainate receptor-operated channels with high and low Ca2+ permeability in single rat retinal ganglion cells

1 reference

12 December 2020

1 reference

12 December 2020

Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2

1 reference

12 December 2020

Caspase-2 mediates neuronal cell death induced by beta-amyloid

1 reference

12 December 2020

Alice in caspase land. A phylogenetic analysis of caspases from worm to man

1 reference

12 December 2020

Non-arteritic anterior ischemic optic neuropathy, PDE-5 inhibitors, and amiodarone: may there be a sex hormone effect for the eye?

1 reference

12 December 2020

Matrix metalloproteases: degradation of the inhibitory environment of the transected optic nerve and the scar by regenerating axons

1 reference

12 December 2020

Identifiers

DOI

10.1038/CDDIS.2011.54

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21677688%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21677688%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

21677688

1 reference