Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival. (Q34202836)

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English	Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival.	scientific article

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26 January 2020

Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival (English)

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26 January 2020

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26 January 2020

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26 January 2020

Manuel López Cabrera

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26 January 2020

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26 January 2020

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Rafael Selgas

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26 January 2020

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Elisa Conde

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26 January 2020

Laura Alegre

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26 January 2020

Ignacio Blanco-Sánchez

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26 January 2020

David Sáenz-Morales

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26 January 2020

Elia Aguado-Fraile

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26 January 2020

Belén Ponte

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26 January 2020

Ana Sáiz

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26 January 2020

Angel Ordoñez

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26 January 2020

Manuel O de Landázuri

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26 January 2020

Fernando Liaño

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26 January 2020

Jose Antonio Sanchez-Tomero

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26 January 2020

María Laura García-Bermejo

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26 January 2020

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14 March 2012

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26 January 2020

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26 January 2020

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26 January 2020

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26 January 2020

e33258

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26 January 2020

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14 March 2012

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Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites

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Differential resolution of inflammation and recovery after renal ischemia-reperfusion injury in Brown Norway compared with Sprague Dawley rats.

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Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

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15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation.

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HIF-1 in the inflammatory microenvironment

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Creatinine kinetics and the definition of acute kidney injury

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Hypoxia response and VEGF-A expression in human proximal tubular epithelial cells in stable and progressive renal disease

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HIF activation protects from acute kidney injury

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Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury

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Hypoxia and the HIF system in kidney disease

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Requirements for proximal tubule epithelial cell detachment in response to ischemia: role of oxidative stress.

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Novel renoprotective actions of erythropoietin: new uses for an old hormone

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Hypoxia inducible factor-1: regulation by nitric oxide in posthypoxic microvascular endothelium.

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Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene

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PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.

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Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription

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Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension.

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Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics

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Immunohistochemical detection of hypoxia-inducible factor-1alpha in human renal allograft biopsies.

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Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide

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The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors

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Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury

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ERK1/2 mediates cytoskeleton and focal adhesion impairment in proximal epithelial cells after renal ischemia.

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Renal ischemia/reperfusion injury: functional tissue preservation by anti-activated {beta}1 integrin therapy.

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Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats

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Repetitive hypoxic preconditioning attenuates renal ischemia/reperfusion induced oxidative injury via upregulating HIF-1 alpha-dependent bcl-2 signaling.

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Signal transduction of MEK/ERK and PI3K/Akt activation by hypoxia/reoxygenation in renal epithelial cells

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Acute kidney injury

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Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension

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Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure

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12 December 2020

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10.1371/JOURNAL.PONE.0033258

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26 January 2020

2012PLoSO...733258C

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26 January 2020

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26 January 2020

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