Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology (Q34343405)

1 August 2017

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title

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology (English)

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1 August 2017

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1

Semenza GL

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1 August 2017

1 August 2001

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Trends in Molecular Medicine

1 August 2017

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1 August 2017

7

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1 August 2017

345-350

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1 August 2017

8

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Remembrance of things PAS: regulation of development by bHLH-PAS proteins

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

In vivo expression of mRNAs encoding hypoxia-inducible factor 1

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT).

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

ARNT-deficient mice and placental differentiation

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Transitional change in interaction between HIF-1 and HNF-4 in response to hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Early expression of angiogenesis factors in acute myocardial ischemia and infarction

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Age-dependent impairment of angiogenesis

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

The function of hypoxia-inducible factor 1 (HIF-1) is impaired in senescent mice

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Interindividual heterogeneity in the hypoxic regulation of VEGF: significance for the development of the coronary artery collateral circulation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Gene-dosing effect and persistence of reduction in ischemic brain injury in mice lacking inducible nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

HIF-1: using two hands to flip the angiogenic switch

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Suppression of tumor growth through disruption of hypoxia-inducible transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Characterization of the alpha1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Identification of a hypoxia response element in the transferrin receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

An essential role for p300/CBP in the cellular response to hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902090-1

7 January 2021

10.1016/S1471-4914(01)02090-1

Identifiers

DOI

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1 August 2017

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PubMed ID

11516994