Cell surface lactate receptor GPR81 is crucial for cancer cell survival (Q34203416)

31 July 2017

title

Cell surface lactate receptor GPR81 is crucial for cancer cell survival (English)

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31 July 2017

9

Huamin Wang

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31 July 2017

Christina L Roland

1

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31 July 2017

Thiruvengadam Arumugam

2

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31 July 2017

Defeng Deng

3

1 reference

31 July 2017

Shi He Liu

4

1 reference

31 July 2017

Bincy Philip

5

1 reference

31 July 2017

Sobeyda Gomez

6

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31 July 2017

William R Burns

7

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31 July 2017

Vijaya Ramachandran

8

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31 July 2017

Zobeida Cruz-Monserrate

10

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31 July 2017

Craig D Logsdon

11

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31 July 2017

language of work or name

English

0 references

publication date

13 June 2014

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31 July 2017

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31 July 2017

volume

74

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31 July 2017

issue

18

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31 July 2017

page(s)

5301-5310

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Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.

31 July 2017

cites work

1 reference

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Mechanistic insights into self-reinforcing processes driving abnormal histogenesis during the development of pancreatic cancer

5 July 2018

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Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells

5 July 2018

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Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay

5 July 2018

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

5 July 2018

1 reference

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Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

5 July 2018

1 reference

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CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis.

5 July 2018

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Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors.

5 July 2018

1 reference

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Lactate: a metabolic key player in cancer

5 July 2018

1 reference

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Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments

5 July 2018

1 reference

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PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.

5 July 2018

1 reference

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Trefoil factor 1 stimulates both pancreatic cancer and stellate cells and increases metastasis

5 July 2018

1 reference

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Hallmarks of Cancer: The Next Generation

5 July 2018

1 reference

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Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis

5 July 2018

1 reference

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Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Understanding the Warburg effect: the metabolic requirements of cell proliferation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Tumor cell metabolism: cancer's Achilles' heel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Statistical significance of quantitative PCR

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Lactate sensitive transcription factor network in L6 cells: activation of MCT1 and mitochondrial biogenesis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Effect of cromolyn on S100P interactions with RAGE and pancreatic cancer growth and invasion in mouse models

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

PGC-1alpha: a key regulator of energy metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

On respiratory impairment in cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Tissue microarrays: applications in neuropathology research, diagnosis, and education.

5 July 2018

1 reference

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Discovery and mapping of ten novel G protein-coupled receptor genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Correlation of high lactate levels in head and neck tumors with incidence of metastasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism.

5 July 2018

1 reference

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Study of GPR81, the lactate receptor, from distant species identifies residues and motifs critical for GPR81 functions

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

PGC-1alpha increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Elucidation of signaling and functional activities of an orphan GPCR, GPR81.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167222

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24928781

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-14-0319

1 reference

31 July 2017

1 reference

31 July 2017

1 reference