Relationship between P-glycoprotein and second-generation antipsychotics. (Q34208133)

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title

Relationship between P-glycoprotein and second-generation antipsychotics (English)

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1

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Stephan Claes

series ordinal

3

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10 February 2020

Geert Dom

series ordinal

4

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author name string

Mariska de Roo

series ordinal

2

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publication date

1 August 2011

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volume

12

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issue

8

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page(s)

1193-1211

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Schizophrenia, "just the facts" 5. Treatment and prevention. Past, present, and future

10 February 2020

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Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver

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C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation

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MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype.

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Clinical significance of a CYP2D6 poor metabolizer--a patient with schizophrenia on risperidone treatment

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Agranulocytosis related to clozapine in monozygotic twins and association with allelic variants of multidrug resistance gene MDR1.

21 January 2018

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Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates

21 January 2018

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Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp).

21 January 2018

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How does the benzamide antipsychotic amisulpride get into the brain?--An in vitro approach comparing amisulpride with clozapine

21 January 2018

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

21 January 2018

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Uptake of clozapine into HL-60 promyelocytic leukaemia cells

21 January 2018

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Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells

21 January 2018

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Relationship between passive permeability, efflux, and predictability of clearance from in vitro metabolic intrinsic clearance

21 January 2018

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In vitro P-glycoprotein affinity for atypical and conventional antipsychotics

21 January 2018

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Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein

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Effect of the novel antipsychotic drug perospirone on P-glycoprotein function and expression in Caco-2 cells

21 January 2018

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Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics

21 January 2018

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Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs

21 January 2018

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In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system

21 January 2018

1 reference

P-glycoprotein and cytochrome P450 3A4 involvement in risperidone transport using an in vitro Caco-2/TC7 model and an in vivo model

21 January 2018

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Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

21 January 2018

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Risperidone and paliperidone inhibit p-glycoprotein activity in vitro.

21 January 2018

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A fluorometric screening assay for drug efflux transporter activity in the blood-brain barrier

21 January 2018

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In vivo model systems in P-glycoprotein-mediated multidrug resistance

21 January 2018

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Utility of Mdr1-gene deficient mice in assessing the impact of P-glycoprotein on pharmacokinetics and pharmacodynamics in drug discovery and development

21 January 2018

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Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice

21 January 2018

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Aripiprazole brain concentration is altered in P-glycoprotein deficient mice

21 January 2018

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P-glycoprotein deficient mouse in situ blood-brain barrier permeability and its prediction using an in combo PAMPA model

21 January 2018

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The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

21 January 2018

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Olanzapine penetration into brain is greater in transgenic Abcb1a P-glycoprotein-deficient mice than FVB1 (wild-type) animals

21 January 2018

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P-glycoprotein interaction with risperidone and 9-OH-risperidone studied in vitro, in knock-out mice and in drug-drug interaction experiments

21 January 2018

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Pharmacodynamic consequences of P-glycoprotein-dependent pharmacokinetics of risperidone and haloperidol in mice

21 January 2018

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The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein

21 January 2018

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Induction of Drug Transporters Alters Disposition of Risperidone - A Study in Mice

21 January 2018

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P-glycoprotein inhibition potentiates the behavioural and neurochemical actions of risperidone in rats.

21 January 2018

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Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone: in vivo evidence of involvement of P-glycoprotein in risperidone disposition

21 January 2018

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Effect of rifampin, an inducer of CYP3A and P-glycoprotein, on the pharmacokinetics of risperidone

21 January 2018

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ABCB1 polymorphisms are associated with clozapine plasma levels in psychotic patients

21 January 2018

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ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine.

21 January 2018

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Pharmacokinetics of olanzapine after single-dose oral administration of standard tablet versus normal and sublingual administration of an orally disintegrating tablet in normal volunteers

21 January 2018

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Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure--an impact similar to male gender or smoking in schizophrenic patients

21 January 2018

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Effects of various factors on steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: lack of impact of MDR-1 genotypes

21 January 2018

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21 January 2018

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ABCB1 polymorphisms influence steady-state plasma levels of 9-hydroxyrisperidone and risperidone active moiety.

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21 January 2018

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21 January 2018

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The relationship between P-glycoprotein (PGP) polymorphisms and response to olanzapine treatment in schizophrenia.

21 January 2018

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Associations between MDR1 gene polymorphisms and schizophrenia and therapeutic response to olanzapine in female schizophrenic patients.

21 January 2018

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21 January 2018

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21 January 2018

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Kinetic analyses for species differences in P-glycoprotein-mediated drug transport.

21 January 2018

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Species differences of inhibitory effects on P-glycoprotein-mediated drug transport.

21 January 2018

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21 January 2018

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Association study of MDR1 and 5-HT2C genetic polymorphisms and antipsychotic-induced metabolic disturbances in female patients with schizophrenia.

21 January 2018

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Placental transfer of quetiapine in relation to P-glycoprotein activity

21 January 2018

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Increased (R)-Methadone Plasma Concentrations by Quetiapine in Cytochrome P450s and ABCB1 Genotyped Patients

21 January 2018

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G2677T and C3435T Genotype and Haplotype Are Associated With HepaticABCB1(MDR1) Expression

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/PGS.11.55

1 reference

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10 February 2020

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