Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia (Q34208940)

31 July 2017

Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia (English)

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31 July 2017

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Guansong Wang

1

1 reference

31 July 2017

Zhiyuan Zhang

2

1 reference

31 July 2017

Zhi Xu

3

1 reference

31 July 2017

Hongjin Yin

4

1 reference

31 July 2017

Li Bai

5

1 reference

31 July 2017

Zhuang Ma

6

1 reference

31 July 2017

Mark A Decoster

7

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31 July 2017

Guisheng Qian

8

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31 July 2017

Guangyu Wu

9

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31 July 2017

language of work or name

English

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publication date

15 September 2010

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Biochimica et Biophysica Acta

31 July 2017

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31 July 2017

1803

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31 July 2017

12

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31 July 2017

1359-1367

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Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors.

31 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Hedgehog signalling: emerging evidence for non-canonical pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor

5 July 2018

1 reference

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Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

5 July 2018

1 reference

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Gene regulation in the adaptive process to hypoxia in lung epithelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Activation of hedgehog signaling inhibits osteoblast differentiation of human mesenchymal stem cells.

5 July 2018

1 reference

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Sonic hedgehog-responsive genes in the fetal prostate

5 July 2018

1 reference

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Endothelial cell dysfunction and cross talk between endothelium and smooth muscle cells in pulmonary arterial hypertension.

5 July 2018

1 reference

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Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice

5 July 2018

1 reference

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Multiple roles for lipids in the Hedgehog signalling pathway

5 July 2018

1 reference

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Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells

5 July 2018

1 reference

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Hypoxia-induced compensatory effect as related to Shh and HIF-1alpha in ischemia embryo rat heart

5 July 2018

1 reference

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Pathogenic mechanisms of pulmonary arterial hypertension

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Sequential activation of JAKs, STATs and xanthine dehydrogenase/oxidase by hypoxia in lung microvascular endothelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

The effects of hypoxia on the cells of the pulmonary vasculature.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Order in the classroom: graded responses to instructive Hh signaling in the CNS.

5 July 2018

1 reference

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Vascular remodeling in transplant vasculopathy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Mechanisms of vascular smooth muscle cell migration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Angiogenesis in chronic lung disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Regulation of Hh/Gli signaling by dual ubiquitin pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Hypoxia, drug therapy and toxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Biomechanical regulation of hedgehog signaling in vascular smooth muscle cells in vitro and in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Activation of heterotrimeric G proteins by Smoothened

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Role of ion channels in acute and chronic responses of the pulmonary vasculature to hypoxia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Interferon-gamma induces Fas trafficking and sensitization to apoptosis in vascular smooth muscle cells via a PI3K- and Akt-dependent mechanism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Aging, smooth muscle cells and vascular pathobiology: implications for atherosclerosis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Effects of hypoxia and hypercapnia on surfactant protein expression proliferation and apoptosis in A549 alveolar epithelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor

5 July 2018

1 reference

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Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation.

5 July 2018

1 reference

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Tissue repair and stem cell renewal in carcinogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Dysregulation of HSG triggers vascular proliferative disorders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Hedgehog signalling in foregut malignancy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Regulation of the cell surface expression and function of angiotensin II type 1 receptor by Rab1-mediated endoplasmic reticulum-to-Golgi transport in cardiac myocytes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

A conserved motif for the transport of G protein-coupled receptors from the endoplasmic reticulum to the cell surface

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Targeting HIF-1 for cancer therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Distinct pathways for the trafficking of angiotensin II and adrenergic receptors from the endoplasmic reticulum to the cell surface: Rab1-independent transport of a G protein-coupled receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Patched acts catalytically to suppress the activity of Smoothened

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Hedgehog-Gli signalling and the growth of the brain.

5 July 2018

1 reference

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Hedgehog is required for murine yolk sac angiogenesis.

5 July 2018

1 reference

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Hedgehog signaling in animal development: paradigms and principles

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

5 July 2018

1 reference

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Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

5 July 2018

1 reference

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Gli1 is a target of Sonic hedgehog that induces ventral neural tube development

5 July 2018

1 reference

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Identification of an amplified, highly expressed gene in a human glioma

5 July 2018

1 reference

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Regulation of proliferation and membrane potential by chloride currents in rat pulmonary artery smooth muscle cells.

5 July 2018

1 reference

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Gli2 influences proliferation in the developing lung through regulation of cyclin expression.

28 October 2018

1 reference

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The effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in rats.

28 October 2018

1 reference

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Hypoxia induces a hedgehog response mediated by HIF-1alpha.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Inhibition of ocular neovascularization by hedgehog blockade.

28 October 2018

1 reference

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The cytotoxic effect of anthrax lethal toxin on human lung cells in vitro and the protective action of bovine antibodies to PA and LF.

28 October 2018

1 reference

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JAK-STAT signaling pathway in pulmonary arterial smooth muscle cells is activated by hypoxia.

28 October 2018

1 reference

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28 October 2018

1 reference

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Bovine distal pulmonary arterial media is composed of a uniform population of well-differentiated smooth muscle cells with low proliferative capabilities.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Fluvastatin enhances the inhibitory effects of a selective angiotensin II type 1 receptor blocker, valsartan, on vascular neointimal formation

28 October 2018

1 reference

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Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956789

Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo.

28 October 2018

1 reference

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Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice

28 October 2018

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12 December 2020

Targeting the Hedgehog pathway in cancer

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12 December 2020

Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells

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12 December 2020

Nitric oxide regulates expression of sonic hedgehog and hypoxia-inducible factor-1alpha in an experimental model of kidney ischemia-reperfusion

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12 December 2020

Role of the JAK/STAT pathway in rat carotid artery remodeling after vascular injury

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12 December 2020

Smooth muscle-mediated connective tissue remodeling in pulmonary hypertension

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12 December 2020

GLI gene expression in bone and soft tissue sarcomas of adult patients correlates with tumor grade

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12 December 2020

Hypoxia stimulates proliferation and interleukin-1alpha production in human vascular smooth muscle cells

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12 December 2020

10.1016/J.BBAMCR.2010.09.002

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DOI

1 reference

31 July 2017

1 reference

31 July 2017

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