Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? (Q34212543)

31 July 2017

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title

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? (English)

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31 July 2017

traumatic brain injury

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author name string

Chrysanthy Ikonomidou

series ordinal

1

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PubMed ID

12849400

31 July 2017

Lechoslaw Turski

series ordinal

2

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31 July 2017

1 October 2002

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31 July 2017

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31 July 2017

1

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31 July 2017

383-386

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31 July 2017

6

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Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Brain lesions in an infant rhesus monkey treated with monsodium glutamate

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Synaptic activity mediates death of hypoxic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

The role of excitatory amino acids and NMDA receptors in traumatic brain injury

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Excitatory amino acids as a final common pathway for neurologic disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Alternative excitotoxic hypotheses

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

L-Glutamate has higher affinity than other amino acids for [3H]-D-AP5 binding sites in rat brain membranes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

The changing landscape of ischaemic brain injury mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: results of two phase III clinical trials. The Selfotel Investigators.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Selfotel in acute ischemic stroke : possible neurotoxic effects of an NMDA antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Future of neuroprotective drugs in doubt

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Aptiganel hydrochloride in acute ischemic stroke: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

N-Methyl-D-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Neuronal death enhanced by N-methyl-D-aspartate antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Immunohistochemical analysis of cyclic AMP response element binding protein phosphorylation in focal cerebral ischemia in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Activated phosphorylation of cyclic AMP response element binding protein is associated with preservation of striatal neurons after focal cerebral ischemia in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Is CREB a key to neuronal survival?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Excitatory amino acids in cerebrospinal fluid following traumatic brain injury in humans.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Plasma and cerebrospinal fluid free amino acid concentration in post-traumatic cerebral oedema in patients with shock

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Excitatory amino acid antagonists and their potential for the treatment of ischaemic brain damage in man.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Acute stroke therapy at the millennium: consummating the marriage between the laboratory and bedside. The Feinberg lecture.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Medical treatment and neuroprotection in traumatic brain injury

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

N-methyl-D-aspartate receptor-mediated increase of neurogenesis in adult rat dentate gyrus following stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

Letter: Neurotoxic effects of glutamate.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2802%2900164-3

7 January 2021

10.1016/S1474-4422(02)00164-3

Identifiers

DOI

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release_zq6drjpsevbt5bxwgnjupgqinm

31 July 2017

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Fatcat

https://api.fatcat.wiki/v0/release/zq6drjpsevbt5bxwgnjupgqinm

24 November 2022

mapped directly with Wikidata item

PubMed ID

12849400

1 reference

PubMed ID

12849400