The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome (Q34214146)

31 July 2017

The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome (English)

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31 July 2017

3

Måns Ehrenberg

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31 July 2017

Tanel Tenson

1

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ORCID Public Data File 2021

author name string

Martin Lovmar

series ordinal

2

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PubMed ID

12860123

31 July 2017

language of work or name

English

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publication date

1 July 2003

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Journal of Molecular Biology

31 July 2017

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31 July 2017

330

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31 July 2017

5

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31 July 2017

1005-1014

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Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms.

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

The structures of four macrolide antibiotics bound to the large ribosomal subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

The structural basis of ribosome activity in peptide bond synthesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

The involvement of RNA in ribosome function

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Erythromycin resistance by ribosome modification

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

The macrolides: erythromycin, clarithromycin, and azithromycin

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Short peptides conferring resistance to macrolide antibiotics

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Macrolide resistance conferred by base substitutions in 23S rRNA.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

The emerging new generation of antibiotic: ketolides

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Structural basis for the antibiotic activity of ketolides and azalides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Interaction of the antibiotics clindamycin and lincomycin with Escherichia coli 23S ribosomal RNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Erythromycin, a peptidyltransferase effector

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Inhibition of protein synthesis by streptogramins and related antibiotics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Location of exit channel for nascent protein in 80S ribosome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

A tunnel in the large ribosomal subunit revealed by three-dimensional image reconstruction

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Regulatory nascent peptides in the ribosomal tunnel

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Release of (oligo) peptidyl-tRNA from ribosomes by erythromycin A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Elongating ribosomes in vivo are refractory to erythromycin

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Selective action of erythromycin on initiating ribosomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Cooperative and Antagonistic Interactions of Peptidyl-tRNA and Antibiotics with Bacterial Ribosomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Movement of the 3'-end of tRNA through the peptidyl transferase centre and its inhibition by antibiotics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Release factor RF3 in E.coli accelerates the dissociation of release factors RF1 and RF2 from the ribosome in a GTP-dependent manner

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

A plasmid-coded and site-directed mutation in Escherichia coli 23S RNA that confers resistance to erythromycin: implications for the mechanism of action of erythromycin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Inhibition of polypeptide synthesis in cell-free systems by virginiamycin S and erythromycin. Evidence for a common mode of action of type B synergimycins and 14-membered macrolides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Action of erythromycin and virginiamycin S on polypeptide synthesis in cell-free systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Nucleotide Sequence of the Gene Coding for the Bacteriophage MS2 Coat Protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

7 January 2021

A coat for all sequences

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https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Insights into erythromycin action from studies of its activity as inducer of resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Receptor site for the 5'-phosphate of elongator tRNAs governs substrate selection by peptidyl-tRNA hydrolase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Origins of minigene-dependent growth inhibition in bacterial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Lincosamide antibiotics stimulate dissociation of peptidyl-tRNA from ribosomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Erythromycin, lincosamides, peptidyl-tRNA dissociation, and ribosome editing.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Ketolide resistance conferred by short peptides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Erythromycin resistance peptides selected from random peptide libraries

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Nucleoside triphosphate regeneration decreases the frequency of translation errors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Rate of translation of natural mRNAs in an optimized in vitro system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

GTP consumption of elongation factor Tu during translation of heteropolymeric mRNAs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Purification procedure for bacterial translational initiation factors IF2 and IF3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

High-speed preparative-scale separation and purification of ribosomal 5S and 5.8S RNA's via Sephacryl S-300 gel filtration chromatography

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

Ribosome structure and the mechanism of translation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900662-4

10.1016/S0022-2836(03)00662-4

7 January 2021

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

12860123