Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine (Q34217662)

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English	Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine	scientific article

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scholarly article

1 reference

Europe PubMed Central

31 July 2017

Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine (English)

1 reference

Europe PubMed Central

31 July 2017

author name string

Lawrence M Gelbert

1

1 reference

Europe PubMed Central

31 July 2017

Shufen Cai

2

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Europe PubMed Central

31 July 2017

Xi Lin

3

1 reference

Europe PubMed Central

31 July 2017

Concepcion Sanchez-Martinez

4

1 reference

Europe PubMed Central

31 July 2017

Miriam Del Prado

5

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Europe PubMed Central

31 July 2017

Maria Jose Lallena

6

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Europe PubMed Central

31 July 2017

Raquel Torres

7

1 reference

Europe PubMed Central

31 July 2017

Rose T Ajamie

8

1 reference

Europe PubMed Central

31 July 2017

Graham N Wishart

9

1 reference

Europe PubMed Central

31 July 2017

Robert Steven Flack

10

1 reference

Europe PubMed Central

31 July 2017

Blake Lee Neubauer

11

1 reference

Europe PubMed Central

31 July 2017

Jamie Young

12

1 reference

Europe PubMed Central

31 July 2017

Edward M Chan

13

1 reference

Europe PubMed Central

31 July 2017

Philip Iversen

14

1 reference

Europe PubMed Central

31 July 2017

Damien Cronier

15

1 reference

Europe PubMed Central

31 July 2017

Emiko Kreklau

16

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Europe PubMed Central

31 July 2017

Alfonso de Dios

17

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Europe PubMed Central

31 July 2017

publication date

13 June 2014

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Europe PubMed Central

31 July 2017

Investigational New Drugs

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Europe PubMed Central

31 July 2017

32

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31 July 2017

5

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Europe PubMed Central

31 July 2017

825-837

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Europe PubMed Central

31 July 2017

copyright license

Creative Commons Attribution 4.0 International

13 June 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

https://scigraph.springernature.com/pub.10.1007/s10637-014-0120-7

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Semi-mechanistic pharmacokinetic/pharmacodynamic modeling of the antitumor activity of LY2835219, a new cyclin-dependent kinase 4/6 inhibitor, in mice bearing human tumor xenografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169866

5 July 2018

PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169866

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A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells

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Brain metastases as preventive and therapeutic targets

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Hallmarks of Cancer: The Next Generation

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5 July 2018

New combination therapies with cell-cycle agents

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Constitutively activated FLT3 phosphorylates BAD partially through pim-1.

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Cyclin-dependent kinase pathways as targets for cancer treatment

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Location, location, location: the role of cyclin D1 nuclear localization in cancer

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Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

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5 July 2018

Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

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5 July 2018

An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines

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5 July 2018

The management of brain metastases

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The genetics of malignant melanoma: lessons from mouse and man.

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The restriction point of the cell cycle

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Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication

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Cyclin D-dependent kinases, INK4 inhibitors and cancer

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To cycle or not to cycle: a critical decision in cancer.

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Regulation of RNA polymerase II activity by CTD phosphorylation and cell cycle control

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Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

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Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patients with locally advanced or metastatic non-small-cell lung cancer

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Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

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Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation

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The regulation of E2F by pRB-family proteins

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Cyclin D1 and human neoplasia

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Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

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The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2

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https://pubmed.ncbi.nlm.nih.gov/24919854

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10.1007/S10637-014-0120-7

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Europe PubMed Central

31 July 2017

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Europe PubMed Central

31 July 2017

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Europe PubMed Central

31 July 2017

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