Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. (Q34217927)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25187556%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET (English)

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16 February 2020

1

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16 February 2020

Katherine C Fuh

2

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16 February 2020

Adam J. Krieg

13

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14

Amato J Giaccia

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16 February 2020

author name string

Laura Castellini

3

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16 February 2020

Kartik Viswanathan

4

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16 February 2020

Elizabeth C Finger

5

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16 February 2020

Anh N Diep

6

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16 February 2020

Edward L LaGory

7

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16 February 2020

Mihalis S Kariolis

8

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16 February 2020

Andy Chan

9

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16 February 2020

David Lindgren

10

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16 February 2020

Håkan Axelson

11

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16 February 2020

Yu R Miao

12

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16 February 2020

language of work or name

English

0 references

publication date

3 September 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25187556%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

16 February 2020

published in

1 reference

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16 February 2020

volume

111

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16 February 2020

page(s)

13373-13378

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16 February 2020

issue

37

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Targeting the hepatocyte growth factor/c-Met signaling pathway in renal cell carcinoma

16 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

HIF1α and HIF2α independently activate SRC to promote melanoma metastases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Pathways and targets in hepatocellular carcinoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Hypoxia-inducible factor-1alpha: molecular-targeted therapy for hepatocellular carcinoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Axl is essential for VEGF-A-dependent activation of PI3K/Akt

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

HGF-independent potentiation of EGFR action by c-Met

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

AXL is an essential factor and therapeutic target for metastatic ovarian cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Gas6 and the receptor tyrosine kinase Axl in clear cell renal cell carcinoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

The human receptor tyrosine kinase Axl gene--promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

28 July 2018

A renaissance for SRC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Gene expression profiling in a renal cell carcinoma cell line: dissecting VHL and hypoxia-dependent pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Identification of the von Hippel-Lindau disease tumor suppressor gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Purification and characterization of hypoxia-inducible factor 1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Tumour suppression by the human von Hippel-Lindau gene product

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Characterization of the invasive and metastatic phenotype in human renal cell carcinoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4169907

Treatment selection in metastatic renal cell carcinoma: expert consensus

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1404848111

Inhibition of transcription elongation by the VHL tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1404848111

Hypoxia-inducible factors in physiology and medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1404848111

A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1404848111

A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1404848111

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1404848111

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1404848111

Inactivation of von Hippel-Lindau gene induces constitutive phosphorylation of MET protein in clear cell renal carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1404848111

Differential expression of Axl and Gas6 in renal cell carcinoma reflecting tumor advancement and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1404848111

Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1404848111

First Axl inhibitor enters clinical trials

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25187556

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1404848111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25187556%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25187556%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25187556%20AND%20SRC:MED&resulttype=core&format=json