AXL is an essential factor and therapeutic target for metastatic ovarian cancer (Q36127308)

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14 February 2020

title

AXL is an essential factor and therapeutic target for metastatic ovarian cancer (English)

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14 February 2020

1 reference

1

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14 February 2020

Katherine C Fuh

2

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14 February 2020

Adam J. Krieg

4

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14 February 2020

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Amato J Giaccia

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14 February 2020

author name string

Tiffany E Taylor

3

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14 February 2020

Margaret Musser

5

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14 February 2020

Jenny Yuan

6

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14 February 2020

Kevin Wei

7

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14 February 2020

Calvin J Kuo

8

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14 February 2020

Teri A Longacre

9

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14 February 2020

language of work or name

English

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publication date

21 September 2010

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14 February 2020

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14 February 2020

volume

70

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14 February 2020

issue

19

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14 February 2020

page(s)

7570-7579

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The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory

14 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408227

Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

2 October 2017

1 reference

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Tumor self-seeding by circulating cancer cells

2 October 2017

1 reference

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Inflammation: a hidden path to breaking the spell of ovarian cancer

2 October 2017

1 reference

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Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis

2 October 2017

1 reference

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The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target

2 October 2017

1 reference

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Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis

2 October 2017

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TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer

2 October 2017

1 reference

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Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1.

2 October 2017

1 reference

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AXL is a potential target for therapeutic intervention in breast cancer progression.

2 October 2017

1 reference

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Role of Gas6 in erythropoiesis and anemia in mice

2 October 2017

1 reference

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Targeting phosphoinositide 3-kinase: moving towards therapy

2 October 2017

1 reference

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Illuminating the metastatic process

2 October 2017

1 reference

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Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL.

2 October 2017

1 reference

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2 October 2017

1 reference

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Mechanisms of transcoelomic metastasis in ovarian cancer.

2 October 2017

1 reference

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Twist mediates suppression of inflammation by type I IFNs and Axl

2 October 2017

1 reference

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Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases

2 October 2017

1 reference

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Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408227

Gonadotropins activate proteolysis and increase invasion through protein kinase A and phosphatidylinositol 3-kinase pathways in human epithelial ovarian cancer cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408227

Expression of axl in lung adenocarcinoma and correlation with tumor progression

2 October 2017

1 reference

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New agents for the treatment of ovarian cancer: the next generation

2 October 2017

1 reference

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Multiple roles for the receptor tyrosine kinase axl in tumor formation

2 October 2017

1 reference

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RETRACTED: Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum

2 October 2017

1 reference

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Ovarian cancer metastasis: integrating insights from disparate model organisms

2 October 2017

1 reference

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Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains

2 October 2017

1 reference

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New functions for the matrix metalloproteinases in cancer progression

2 October 2017

1 reference

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Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

2 October 2017

1 reference

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The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy

2 October 2017

1 reference

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Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family

2 October 2017

1 reference

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Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer

2 October 2017

1 reference

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Precursor lesions of ovarian epithelial malignancy

2 October 2017

1 reference

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Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.

2 October 2017

1 reference

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Expression of the receptor protein-tyrosine kinases Tyro-3, Axl, and mer in the developing rat central nervous system

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408227

Tyro-3 family receptors are essential regulators of mammalian spermatogenesis

2 October 2017

1 reference

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Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408227

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408227

R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408227

Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408227

Identification of genes associated with ovarian cancer metastasis using microarray expression analysis.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408227

Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408227

AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408227

Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice

23 September 2018

1 reference

12 December 2020

GAS6 induces Axl-mediated chemotaxis of vascular smooth muscle cells

1 reference

12 December 2020

Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer

1 reference

12 December 2020

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

1 reference

12 December 2020

10.1158/0008-5472.CAN-10-1267

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20858715%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

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14 February 2020

1 reference