Size matters: use of YACs, BACs and PACs in transgenic animals (Q34220676)

31 July 2017

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title

Size matters: use of YACs, BACs and PACs in transgenic animals (English)

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31 July 2017

Giraldo P

1

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31 July 2017

Montoliu L

series ordinal

2

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31 July 2017

language of work or name

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1 April 2001

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31 July 2017

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31 July 2017

10

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31 July 2017

2

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31 July 2017

83-103

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https://scigraph.springernature.com/pub.10.1023/a:1008918913249

31 July 2017

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cites work

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs

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12 December 2020

Production of pigs transgenic for human regulators of complement activation using YAC technology

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12 December 2020

Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins

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12 December 2020

A locus control region at -12 kb of the tyrosinase gene

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12 December 2020

A method for high efficiency YAC lipofection into murine embryonic stem cells

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12 December 2020

BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin.

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12 December 2020

YACs, BACs, PACs and MACs: artificial chromosomes as research tools

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12 December 2020

A positive selection vector for cloning high molecular weight DNA by the bacteriophage P1 system: improved cloning efficacy

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12 December 2020

Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse

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12 December 2020

Position-independent and copy-number-related expression of a goat bacterial artificial chromosome alpha-lactalbumin gene in transgenic mice.

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12 December 2020

Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region.

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12 December 2020

Alterations of yeast artificial chromosome transgenic sequences in stretched embryonic stem-cell chromatin visualized by fluorescence in situ hybridization

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12 December 2020

Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.

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12 December 2020

Isolation of yeast artificial chromosomes free of endogenous yeast chromosomes: construction of alternate hosts with defined karyotypic alterations

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12 December 2020

Position-independent, high-level expression of the human beta-globin gene in transgenic mice

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12 December 2020

Mutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic mice

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12 December 2020

Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

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12 December 2020

Expression of the human cholesterol 7alpha-hydroxylase gene in transgenic mice

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12 December 2020

High-avidity human IgG kappa monoclonal antibodies from a novel strain of minilocus transgenic mice.

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12 December 2020

Faithful expression of the Myf-5 gene during mouse myogenesis requires distant control regions: a transgene approach using yeast artificial chromosomes

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12 December 2020

Transgenic modification of cows milk for value-added processing

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12 December 2020

Chromatin structure and gene activity

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12 December 2020

Apolipoprotein B gene expression in a series of human apolipoprotein B transgenic mice generated with recA-assisted restriction endonuclease cleavage-modified bacterial artificial chromosomes. An intestine-specific enhancer element is located betwee

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12 December 2020

Rapid induction of B-cell lymphomas in mice carrying a human IgH/c-mycYAC

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12 December 2020

Recovery and potential utility of YACs as circular YACs/BACs

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12 December 2020

Mutagenesis of the human apolipoprotein B gene in a yeast artificial chromosome reveals the site of attachment for apolipoprotein(a)

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12 December 2020

YAC transgenics and the study of genetics and human disease

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12 December 2020

Engineering EGFP reporter constructs into a 200 kb human beta-globin BAC clone using GET Recombination

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12 December 2020

A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice.

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12 December 2020

Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector

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12 December 2020

Transgenic mice expressing a human apolipoprotein[a] allele

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12 December 2020

Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus

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12 December 2020

A new logic for DNA engineering using recombination in Escherichia coli

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12 December 2020

Construction of a mouse model of Charcot-Marie-Tooth disease type 1A by pronuclear injection of human YAC DNA.

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12 December 2020

Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages.

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12 December 2020

Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants

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12 December 2020

A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype

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12 December 2020

Xist yeast artificial chromosome transgenes function as X-inactivation centers only in multicopy arrays and not as single copies

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12 December 2020

Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype

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12 December 2020

Visualization of alpha9 acetylcholine receptor expression in hair cells of transgenic mice containing a modified bacterial artificial chromosome

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12 December 2020

Effect of flanking matrix attachment regions on the expression of microinjected transgenes during preimplantation development of mouse embryos.

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12 December 2020

Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice

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12 December 2020

Yeast kar1 mutants provide an effective method for YAC transfer to new hosts

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12 December 2020

Introns increase transcriptional efficiency in transgenic mice

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12 December 2020

Xist expression from an Xist YAC transgene carried on the mouse Y chromosome

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12 December 2020

A simple and efficient method for making site-directed mutants, deletions, and fusions of large DNA such as P1 and BAC clones

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12 December 2020

Beta-globin YAC transgenes exhibit uniform expression levels but position effect variegation in mice

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12 December 2020

Chromatin domains as potential units of eukaryotic gene function

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12 December 2020

A 5' differentially methylated sequence and the 3'-flanking region are necessary for H19 transgene imprinting

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12 December 2020

Complete sequence of the yeast artificial chromosome cloning vector pYAC4.

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12 December 2020

Association of the 5'HS4 sequence of the chicken beta-globin locus control region with human EF1 alpha gene promoter induces ubiquitous and high expression of human CD55 and CD59 cDNAs in transgenic rabbits.

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12 December 2020

A dicistronic construct allows easy detection of human CFTR expression from YAC DNA in human cells.

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12 December 2020

Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis

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12 December 2020

Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region

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12 December 2020

YAC transgene-mediated olfactory receptor gene choice

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12 December 2020

Rapid identification of essential and nonessential herpesvirus genes by direct transposon mutagenesis

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12 December 2020

Position effects on eukaryotic gene expression

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12 December 2020

Insertion of disease-causing mutations in BACs by homologous recombination in Escherichia coli

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12 December 2020

Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development

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12 December 2020

Expression of the human beta-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice

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12 December 2020

An efficient recombination system for chromosome engineering in Escherichia coli

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12 December 2020

Human X inactivation center induces random X chromosome inactivation in male transgenic mice

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12 December 2020

Transgenic mice generated by pronuclear injection of a yeast artificial chromosome.

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12 December 2020

Generation of a 50,000-member human DNA library with an average DNA insert size of 75-100 kbp in a bacteriophage P1 cloning vector

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12 December 2020

Manipulating large genomic clones via in vivo recombination in bacteria.

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12 December 2020

Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene.

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12 December 2020

Apolipoprotein(a) yeast artificial chromosome transgenic rabbits. Lipoprotein(a) assembly with human and rabbit apolipoprotein B.

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12 December 2020

Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors

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12 December 2020

Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes

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12 December 2020

Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosome

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12 December 2020

Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin kappa locus.

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12 December 2020

Genomic interval engineering of mice identifies a novel modulator of triglyceride production

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12 December 2020

Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome.

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12 December 2020

Transcriptional regulation in endoderm development: characterization of an enhancer controlling Hnf3g expression by transgenesis and targeted mutagenesis

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12 December 2020

YAC rescue of downless locus mutations in mice

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12 December 2020

A new approach for studying gene regulation by distant DNA elements in transgenic mice

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12 December 2020

Production of pigs transgenic for human regulators of complement activation.

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12 December 2020

Transgenic mice carrying an Xist-containing YAC.

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12 December 2020

Position-independent and high-level expression of human alpha-lactalbumin in the milk of transgenic rats carrying a 210-kb YAC DNA

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12 December 2020

Visualization of large DNA molecules by electron microscopy with polyamines: application to the analysis of yeast endogenous and artificial chromosomes

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12 December 2020

LCR-dependent gene expression in beta-globin YAC transgenics: detailed structural studies validate functional analysis even in the presence of fragmented YACs.

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12 December 2020

A recombinogenic targeting method to modify large-inserts for cis-regulatory analysis in transgenic mice: construction and expression of a 100-kb, zebrafish Hoxa-11b-lacZ reporter gene.

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12 December 2020

Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a).

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12 December 2020

A new bacteriophage P1-derived vector for the propagation of large human DNA fragments

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12 December 2020

Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury.

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12 December 2020

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

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12 December 2020

Transgenic mice expressing human ApoB95 and ApoB97. Evidence that sequences within the carboxyl-terminal portion of human apoB100 are important for the assembly of lipoprotein

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12 December 2020

Analysis of mammalian central nervous system gene expression and function using bacterial artificial chromosome-mediated transgenesis

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12 December 2020

Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

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12 December 2020

Analysis of control elements for position-independent expression of human alpha-lactalbumin YAC.

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12 December 2020

YAC transgenic analysis reveals Wilms' tumour 1 gene activity in the proliferating coelomic epithelium, developing diaphragm and limb.

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12 December 2020

Generation of transgenic mice with yeast artificial chromosomes

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12 December 2020

Efficient and precise engineering of a 200 kb beta-globin human/bacterial artificial chromosome in E. coli DH10B using an inducible homologous recombination system

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12 December 2020

Isolated sequences from the linked Myf-5 and MRF4 genes drive distinct patterns of muscle-specific expression in transgenic mice.

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12 December 2020

Imprinted expression of the Igf2r gene depends on an intronic CpG island.

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12 December 2020

The mouse tyrosinase promoter is sufficient for expression in melanocytes and in the pigmented epithelium of the retina

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12 December 2020

Locus control regions: coming of age at a decade plus

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12 December 2020

Functional screening of an asthma QTL in YAC transgenic mice.

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12 December 2020

Germ line transmission of a yeast artificial chromosome spanning the murine alpha 1(I) collagen locus

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12 December 2020

Androgen receptor YAC transgenic mice carrying CAG 45 alleles show trinucleotide repeat instability.

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12 December 2020

Insertion of expanded CAG trinucleotide repeat motifs into a yeast artificial chromosome containing the human Machado-Joseph disease gene

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12 December 2020

Heterologous introns can enhance expression of transgenes in mice

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12 December 2020

High-level expressing YAC vector for transgenic animal bioreactors

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12 December 2020

Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain

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12 December 2020

B-cell tumorigenesis in mice carrying a yeast artificial chromosome-based immunoglobulin heavy/c-myc translocus is independent of the heavy chain intron enhancer (Emu).

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12 December 2020

Human XIST yeast artificial chromosome transgenes show partial X inactivation center function in mouse embryonic stem cells

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12 December 2020

Correct function of the locus control region may require passage through a nonerythroid cellular environment.

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12 December 2020

Linearization and purification of BAC DNA for the development of transgenic mice

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12 December 2020

Dominant expression of a 1.3 Mb human Ig kappa locus replacing mouse light chain production.

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12 December 2020

Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice

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12 December 2020

Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion

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12 December 2020

High resolution DNA fiber-fish on yeast artificial chromosomes: direct visualization of DNA replication

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12 December 2020

Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb betas-globin yeast artificial chromosome: A mouse model of sickle cell anemia

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12 December 2020

Insertion of a pathogenic mutation into a yeast artificial chromosome containing the human amyloid precursor protein gene

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12 December 2020

Retrofitting vectors for Escherichia coli-based artificial chromosomes (PACs and BACs) with markers for transfection studies

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12 December 2020

Functional identification of the mouse circadian Clock gene by transgenic BAC rescue

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12 December 2020

Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities.

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12 December 2020

Rational design of an animal model for Alzheimer's disease: introduction of multiple human genomic transgenes to reproduce AD pathology in a rodent

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12 December 2020

High-level rearrangement and transcription of yeast artificial chromosome-based mouse Ig kappa transgenes containing distal regions of the contig

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12 December 2020

Efficient Cre-lox linearisation of BACs: applications to physical mapping and generation of transgenic animals

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12 December 2020

Single-step conversion of P1 and P1 artificial chromosome clones into yeast artificial chromosomes

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12 December 2020

Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription

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12 December 2020

YAC transgenesis in farm animals: rescue of albinism in rabbits

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12 December 2020

A simple assay to determine the functionality of Cre or FLP recombination targets in genomic manipulation constructs.

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12 December 2020

YAC transgenes: bigger is probably better

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12 December 2020

Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2

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12 December 2020

Germ-line transformation of mice

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12 December 2020

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

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12 December 2020

The use of yeast artificial chromosomes in transgenic animals: expression studies of the tyrosinase gene in transgenic mice

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12 December 2020

Artificial chromosome transgenesis reveals long-distance negative regulation of rag1 in zebrafish.

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12 December 2020

Rapid modification of bacterial artificial chromosomes by ET-recombination.

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12 December 2020

A method for the generation of YAC transgenic mice by pronuclear microinjection

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12 December 2020

An improved method for routine preparation of intact artificial chromosome DNA (340-1000 kb) for transfection into human cells

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12 December 2020

Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice

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12 December 2020

Melanization in albino mice transformed by introducing cloned mouse tyrosinase gene

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12 December 2020

The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.

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12 December 2020

Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia

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12 December 2020

Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

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12 December 2020

Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains

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12 December 2020

Transgenic analysis of a 100-kb human beta-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome

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12 December 2020

Deletion of a region that is a candidate for the difference between the deletion forms of hereditary persistence of fetal hemoglobin and deltabeta-thalassemia affects beta- but not gamma-globin gene expression

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12 December 2020

YAC transgenesis: a study of conditions to protect YAC DNA from breakage and a protocol for transfection

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12 December 2020

A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice

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12 December 2020

Production and analysis of transgenic mice containing yeast artificial chromosomes

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12 December 2020

Evolutionary duplication of a hepatic control region in the human apolipoprotein E gene locus. Identification of a second region that confers high level and liver-specific expression of the human apolipoprotein E gene in transgenic mice

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12 December 2020

Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice.

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12 December 2020

Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.

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12 December 2020

Production of transgenic mice with yeast artificial chromosomes

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12 December 2020

Position-independent expression of a human nerve growth factor-luciferase reporter gene cloned on a yeast artificial chromosome vector

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12 December 2020

A generic intron increases gene expression in transgenic mice

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12 December 2020

Germ-line transmission and expression of a human-derived yeast artificial chromosome

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12 December 2020

Microinjection of intact 200- to 500-kb fragments of YAC DNA into mammalian cells

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12 December 2020

Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes

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12 December 2020

Exploring gene function: use of yeast artificial chromosome transgenesis

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12 December 2020

Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.

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12 December 2020

Production of gene-targeted sheep by nuclear transfer from cultured somatic cells

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12 December 2020

Imprinting of Igf2 and H19 from a 130 kb YAC transgene.

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12 December 2020

A membrane cofactor protein transgenic mouse model for the study of discordant xenograft rejection

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12 December 2020

Pre-selection of integration sites imparts repeatable transgene expression

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12 December 2020

The apolipoprotein(a) gene is regulated by sex hormones and acute-phase inducers in YAC transgenic mice.

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12 December 2020

A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

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12 December 2020

YAC vectors. Humanizing the mouse genome

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12 December 2020

Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2.

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12 December 2020

Partial rescue of GATA-3 by yeast artificial chromosome transgenes.

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12 December 2020

Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs

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12 December 2020

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene

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12 December 2020

Targeting expression to the mammary gland: intronic sequences can enhance the efficiency of gene expression in transgenic mice

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12 December 2020

YAC transfer by microinjection.

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12 December 2020

Complementation of null CF mice with a human CFTR YAC transgene

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12 December 2020

Effects of altered gene order or orientation of the locus control region on human beta-globin gene expression in mice.

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12 December 2020

Yeast artificial chromosomes: tools for mapping and analysis of complex genomes.

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12 December 2020

Use of yeast artificial chromosomes to express genes in transgenic mice

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12 December 2020

The human beta globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in transgenic mice.

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12 December 2020

Human apolipoprotein B transgenic mice generated with 207- and 145-kilobase pair bacterial artificial chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine.

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12 December 2020

Germ line transmission of yeast artificial chromosomes in transgenic mice.

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12 December 2020

Functional screening and complex traits: human 21q22.2 sequences affecting learning in mice

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12 December 2020

The structural H19 gene is required for transgene imprinting

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12 December 2020

Expression of large genomic clones in transgenic mice: new insights into apolipoprotein B structure, function and regulation

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12 December 2020

Identifiers

DOI

10.1023/A:1008918913249

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Dimensions Publication ID

31 July 2017

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