Pharmacokinetic modeling of an induction regimen for in vivo combined testing of novel drugs against pediatric acute lymphoblastic leukemia xenografts. (Q34221738)

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English	Pharmacokinetic modeling of an induction regimen for in vivo combined testing of novel drugs against pediatric acute lymphoblastic leukemia xenografts.	scientific article

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28 January 2020

Pharmacokinetic modeling of an induction regimen for in vivo combined testing of novel drugs against pediatric acute lymphoblastic leukemia xenografts (English)

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28 January 2020

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lymphoblastic leukemia

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pharmacokinetics

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3

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28 January 2020

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28 January 2020

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28 January 2020

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Ingrid Boehm

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Clinton F Stewart

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Clinton F Stewart

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Hernan Carol

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28 January 2020

Barbara Szymanska

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Barbara Szymanska

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Urszula Wilczynska-Kalak

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Urszula Wilczynska-Kalak

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28 January 2020

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Natalia L M Liem

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28 January 2020

Daniel Groepper

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29 March 2012

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28 January 2020

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28 January 2020

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28 January 2020

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28 January 2020

e33894

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28 January 2020

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Creative Commons Attribution 4.0 International

29 March 2012

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0 references

Biology, risk stratification, and therapy of pediatric acute leukemias: an update

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28 July 2018

Recent research advances in childhood acute lymphoblastic leukemia

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28 July 2018

The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs

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28 July 2018

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

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28 July 2018

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

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28 July 2018

Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program

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28 July 2018

BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.

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28 July 2018

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

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28 July 2018

Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis

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28 July 2018

Pharmacological and clinical evaluation of L-asparaginase in the treatment of leukemia.

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28 July 2018

Long-term follow-up of people who have survived cancer during childhood

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28 July 2018

Childhood acute lymphoblastic leukaemia and relapse

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28 July 2018

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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28 July 2018

DIMSCAN: a microcomputer fluorescence-based cytotoxicity assay for preclinical testing of combination chemotherapy.

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28 July 2018

Pharmacokinetic/pharmacodynamic relationships of asparaginase formulations: the past, the present and recommendations for the future

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28 July 2018

Therapeutic synergy of oral taxane BMS-275183 and cetuximab versus human tumor xenografts

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Can the pharmaceutical industry reduce attrition rates?

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28 July 2018

Microtubules as a target for anticancer drugs

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28 July 2018

Monitoring of Erwinia asparaginase therapy in childhood ALL in the Nordic countries

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28 July 2018

Outcome of patients treated for relapsed or refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium study

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21 January 2018

Clinical outcome of children with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia treated between 1995 and 2005.

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Childhood all blasts retain phenotypic and genotypic characteristics upon long-term serial passage in NOD/SCID mice.

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21 January 2018

Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies

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21 January 2018

Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.

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21 January 2018

The pharmacokinetic profiles of dexamethasone and methylprednisolone concentration in perilymph and plasma following systemic and local administration

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21 January 2018

Asparaginase may influence dexamethasone pharmacokinetics in acute lymphoblastic leukemia

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21 January 2018

Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia.

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21 January 2018

Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition.

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21 January 2018

Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines

1 reference

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21 January 2018

Vincristine pharmacokinetics is related to clinical outcome in children with standard risk acute lymphoblastic leukemia

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Dexamethasone as a probe for vinorelbine clearance

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21 January 2018

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21 January 2018

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21 January 2018

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

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Growth of human T-cell lineage acute leukemia in severe combined immunodeficiency (SCID) mice and non-obese diabetic SCID mice

1 reference

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Good engraftment of B-cell precursor ALL in NOD-SCID mice

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between topotecan systemic exposure and tumor response in human neuroblastoma xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/22479469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of human B-cell precursor leukemia in SCID mice by using a combination of the anti-CD19 immunotoxin B43-PAP with the standard chemotherapeutic drugs vincristine, methylprednisolone, and L-asparaginase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22479469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monitoring of engraftment and progression of acute lymphoblastic leukemia in individual NOD/SCID mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22479469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/22479469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transition of pemphigus vulgaris into pemphigus foliaceus confirmed by antidesmoglein ELISA profile

1 reference

https://pubmed.ncbi.nlm.nih.gov/22479469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vincristine in childhood leukaemia: no pharmacokinetic rationale for dose reduction in adolescents

1 reference

https://pubmed.ncbi.nlm.nih.gov/22479469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22479469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0033894

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28 January 2020

2012PLoSO...733894S

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28 January 2020

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28 January 2020

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