Trithorax group proteins: switching genes on and keeping them active (Q34235226)

31 July 2017

Trithorax group proteins: switching genes on and keeping them active (English)

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31 July 2017

Bernd Schuettengruber

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object named as

Bernd Schuettengruber

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31 July 2017

Anne-Marie Martinez

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31 July 2017

Nicola Iovino

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3

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31 July 2017

Giacomo Cavalli

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4

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31 July 2017

23 November 2011

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Nature Reviews Molecular Cell Biology

31 July 2017

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31 July 2017

12

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31 July 2017

12

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31 July 2017

799-814

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https://scigraph.springernature.com/pub.10.1038/nrm3230

31 July 2017

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Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

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Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins

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An MLL/COMPASS subunit functions in the C. elegans dosage compensation complex to target X chromosomes for transcriptional regulation of gene expression

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Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene

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CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.

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Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference

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Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers

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GC-rich sequence elements recruit PRC2 in mammalian ES cells

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CpG islands influence chromatin structure via the CpG-binding protein Cfp1.

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NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters

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Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

21 January 2018

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A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

21 January 2018

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Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain

21 January 2018

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Prediction of Polycomb target genes in mouse embryonic stem cells

21 January 2018

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Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc

21 January 2018

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The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

21 January 2018

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Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling

21 January 2018

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Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice

21 January 2018

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Intergenic transcription through a polycomb group response element counteracts silencing

21 January 2018

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Noncoding RNAs of trithorax response elements recruit Drosophila Ash1 to Ultrabithorax

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Genome regulation by polycomb and trithorax proteins

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Long noncoding RNAs with enhancer-like function in human cells

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Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis

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Double chromodomains cooperate to recognize the methylated histone H3 tail

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Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns

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Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions

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RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells

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A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation

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Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

21 January 2018

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Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation

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WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

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PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

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Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes

21 January 2018

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The language of histone crosstalk

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Alternative epigenetic chromatin states of polycomb target genes

21 January 2018

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The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins

21 January 2018

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Genome-wide chromatin occupancy analysis reveals a role for ASH2 in transcriptional pausing.

21 January 2018

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Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4

21 January 2018

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Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression

21 January 2018

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Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity.

21 January 2018

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AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia

21 January 2018

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A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

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Expression of leukemic MLL fusion proteins in Drosophila affects cell cycle control and chromosome morphology.

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The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression

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The regulation of INK4/ARF in cancer and aging

21 January 2018

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Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

21 January 2018

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Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

21 January 2018

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A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

21 January 2018

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Reduction of menin expression enhances cell proliferation and is tumorigenic in intestinal epithelial cells

21 January 2018

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Menin induces apoptosis in murine embryonic fibroblasts

21 January 2018

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Functional interaction between tumor suppressor menin and activator of S-phase kinase

21 January 2018

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DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation

21 January 2018

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Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis

21 January 2018

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MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia

21 January 2018

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A gene-trap strategy identifies quiescence-induced genes in synchronized myoblasts

21 January 2018

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MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation

21 January 2018

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E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.

21 January 2018

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Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.

21 January 2018

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Mitotic inactivation of a human SWI/SNF chromatin remodeling complex

21 January 2018

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Biphasic MLL takes helm at cell cycle control: implications in human mixed lineage leukemia

21 January 2018

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Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

21 January 2018

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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

21 January 2018

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pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

21 January 2018

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

21 January 2018

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SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus

21 January 2018

1 reference

Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint

21 January 2018

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Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.

21 January 2018

1 reference

Characterization of DNA damage-dependent cell cycle checkpoints in a menin-deficient model

21 January 2018

1 reference

The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene

21 January 2018

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Menin stimulates homology-directed DNA repair

21 January 2018

1 reference

Genetic screens for enhancers of brahma reveal functional interactions between the BRM chromatin-remodeling complex and the delta-notch signal transduction pathway in Drosophila

21 January 2018

1 reference

Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes

21 January 2018

1 reference

Genetic and epigenetic mechanisms regulating hedgehog expression in the Drosophila wing.

21 January 2018

1 reference

Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23)

21 January 2018

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

21 January 2018

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The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila

21 January 2018

1 reference

A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network.

21 January 2018

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Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling.

21 January 2018

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The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth

21 January 2018

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c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

21 January 2018

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Su(z)2 antagonizes auto-repression of Myc in Drosophila, increasing Myc levels and subsequent trans-activation

21 January 2018

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Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1

21 January 2018

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The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

21 January 2018

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p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation

21 January 2018

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p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci

21 January 2018

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Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation

21 January 2018

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Histone code pathway involving H3 S28 phosphorylation and K27 acetylation activates transcription and antagonizes polycomb silencing

21 January 2018

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Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex

21 January 2018

1 reference

Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.

21 January 2018

1 reference

Fgfr3 is a transcriptional target of Ap2delta and Ash2l-containing histone methyltransferase complexes

21 January 2018

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The ISWI-containing NURF complex regulates the output of the canonical Wingless pathway

21 January 2018

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The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation

21 January 2018

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The Putzig-NURF nucleosome remodeling complex is required for ecdysone receptor signaling and innate immunity in Drosophila melanogaster.

21 January 2018

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The nucleosome remodeling factor (NURF) regulates genes involved in Drosophila innate immunity.

21 January 2018

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Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates

21 January 2018

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Regulation of chromatin remodeling by inositol polyphosphates

21 January 2018

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Embryonic stem cell lines derived from human blastocysts

21 January 2018

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Integration of external signaling pathways with the core transcriptional network in embryonic stem cells

21 January 2018

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Dissecting self-renewal in stem cells with RNA interference

21 January 2018

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An extended transcriptional network for pluripotency of embryonic stem cells

21 January 2018

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T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways

21 January 2018

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Chromatin states in pluripotent, differentiated, and reprogrammed cells

21 January 2018

1 reference

Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells

21 January 2018

1 reference

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

21 January 2018

1 reference

The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis

21 January 2018

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Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains

21 January 2018

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Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation

21 January 2018

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Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.

21 January 2018

1 reference

MLL5 contributes to hematopoietic stem cell fitness and homeostasis

21 January 2018

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Epigenetic regulation of neural gene expression and neuronal function

21 January 2018

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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

21 January 2018

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Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.

21 January 2018

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Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development

21 January 2018

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Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex

21 January 2018

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The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment

21 January 2018

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High histone acetylation and decreased polycomb repressive complex 2 member levels regulate gene specific transcriptional changes during early embryonic stem cell differentiation induced by retinoic acid.

21 January 2018

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Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation

21 January 2018

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Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells.

21 January 2018

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Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis

21 January 2018

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Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal.

21 January 2018

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MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing

21 January 2018

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Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation.

21 January 2018

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A role for Set1/MLL-related components in epigenetic regulation of the Caenorhabditis elegans germ line

21 January 2018

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Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells

21 January 2018

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SWI/SNF-Brg1 regulates self-renewal and occupies core pluripotency-related genes in embryonic stem cells.

21 January 2018

1 reference

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes

21 January 2018

1 reference

ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a

21 January 2018

1 reference

Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development

21 January 2018

1 reference

The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression

21 January 2018

1 reference

Baf60c is essential for function of BAF chromatin remodelling complexes in heart development

21 January 2018

1 reference

An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network.

21 January 2018

1 reference

A unique chromatin signature uncovers early developmental enhancers in humans

21 January 2018

1 reference

Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells

21 January 2018

1 reference

Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes

21 January 2018

1 reference

Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones

21 January 2018

1 reference

A model for transmission of the H3K27me3 epigenetic mark

21 January 2018

1 reference

Role of the polycomb protein EED in the propagation of repressive histone marks

21 January 2018

1 reference

Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll.

21 January 2018

1 reference

A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit.

21 January 2018

1 reference

Differential expression of bithorax complex genes in the absence of the extra sex combs and trithorax genes.

21 January 2018

2 references

21 January 2018

12 December 2020

Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T-cell acute lymphoblastic leukemia

1 reference

Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis

21 January 2018

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Chd1 regulates open chromatin and pluripotency of embryonic stem cells

31 March 2020

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A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

31 March 2020

1 reference

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

31 March 2020

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Mechanisms of polycomb gene silencing: knowns and unknowns

31 March 2020

1 reference

Multiple endocrine neoplasia type 1 (MEN1) as a cancer predisposition syndrome: clues into the mechanisms of MEN1-related carcinogenesis

31 March 2020

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12 December 2020

The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis

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12 December 2020

The molecular basis for metameric pattern in the Drosophila embryo

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12 December 2020

Transcriptional activation by the Myc oncoprotein.

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12 December 2020

Menin associates with FANCD2, a protein involved in repair of DNA damage

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12 December 2020

Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection

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12 December 2020

trithorax and the regulation of homeotic gene expression in Drosophila: a historical perspective.

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12 December 2020

The molecular basis for metameric pattern in the Drosophila embryo

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19 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1242/DEV.101.1.1

Identifiers

DOI

10.1038/NRM3230

1 reference

Dimensions Publication ID

31 July 2017

0 references

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