Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats (Q34236634)

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English	Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats	scientific article

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scholarly article

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PubMed publication ID

31 July 2017

Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats (English)

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31 July 2017

author name string

John P Redrobe

1

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31 July 2017

Lisbeth Elster

2

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31 July 2017

Kristen Frederiksen

3

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31 July 2017

Christoffer Bundgaard

4

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31 July 2017

Inge E M de Jong

5

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31 July 2017

Garrick P Smith

6

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31 July 2017

Anne Techau Bruun

7

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31 July 2017

Peter H Larsen

8

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31 July 2017

Michael Didriksen

9

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31 July 2017

publication date

29 November 2011

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31 July 2017

Psychopharmacology

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31 July 2017

221

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31 July 2017

3

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31 July 2017

451-468

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Europe PubMed Central

PubMed publication ID

31 July 2017

Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine

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Preclinical and clinical pharmacology of the GABAA receptor alpha5 subtype-selective inverse agonist alpha5IA.

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GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement

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L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors.

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RO4938581, a novel cognitive enhancer acting at GABAA alpha5 subunit-containing receptors

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CNTRICS final task selection: executive control

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Evaluation of a neurodevelopmental model of schizophrenia--early postnatal PCP treatment in attentional set-shifting.

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Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting.

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Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats.

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Impairment in perceptual attentional set-shifting following PCP administration: a rodent model of set-shifting deficits in schizophrenia

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A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data

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Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat--a back translational study

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Executive function in first-episode schizophrenia.

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The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia

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The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction

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21 January 2018

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropsychological evidence for frontostriatal dysfunction in schizophrenia

2 references

https://api.crossref.org/works/10.1007%2FS00213-011-2593-9

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GABAA receptors: subtypes, regional distribution, and function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodevelopmental consequences of early exposure to phencyclidine and related drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptors, cognition and schizophrenia--testing the validity of the NMDA receptor hypofunction hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modelling prefrontal cortex deficits in schizophrenia: implications for treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired recognition memory in rats after damage to the hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term potentiation and cognitive drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[3H]RY 80: A high-affinity, selective ligand for gamma-aminobutyric acidA receptors containing alpha-5 subunits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Medial frontal cortex mediates perceptual attentional set shifting in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A selective decrease in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine system dysregulation by the hippocampus: implications for the pathophysiology and treatment of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subanesthetic doses of ketamine stimulate psychosis in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memory impairment in schizophrenia: a meta-analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22124672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1007/S00213-011-2593-9

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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