Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction (Q34241307)

31 July 2017

Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction (English)

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31 July 2017

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10

Paul Dent

1 reference

31 July 2017

Anindita Das

1

1 reference

31 July 2017

David Durrant

2

1 reference

31 July 2017

Clint Mitchell

3

1 reference

31 July 2017

Eric Mayton

4

1 reference

31 July 2017

Nicholas N Hoke

5

1 reference

31 July 2017

Fadi N Salloum

6

1 reference

31 July 2017

Margaret A Park

7

1 reference

31 July 2017

Ian Qureshi

8

1 reference

31 July 2017

Ray Lee

9

1 reference

31 July 2017

Rakesh C Kukreja

11

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31 July 2017

language of work or name

English

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publication date

30 September 2010

1 reference

Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

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31 July 2017

107

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31 July 2017

42

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31 July 2017

18202-18207

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Sulindac confers high level ischemic protection to the heart through late preconditioning mechanisms

31 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Understanding the Warburg effect: the metabolic requirements of cell proliferation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Topical sulindac combined with hydrogen peroxide in the treatment of actinic keratoses

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Ciprofloxacin sensitizes hormone-refractory prostate cancer cell lines to doxorubicin and docetaxel treatment on a schedule-dependent manner.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Brick by brick: metabolism and tumor cell growth

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Use of cardiac markers to assess the toxic effects of anthracyclines given to children with cancer: a systematic review.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Rationale for phosphodiesterase 5 inhibitor use post-radical prostatectomy: experimental and clinical review.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Therapeutic integration of c-myc and bcl-2 antisense molecules with docetaxel in a preclinical model of hormone-refractory prostate cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Protectors against doxorubicin-induced cardiotoxicity: flavonoids

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Pharmacological preconditioning with sildenafil: Basic mechanisms and clinical implications

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Liposomal anthracyclines in metastatic breast cancer: clinical update

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Phase I and II study of exisulind in combination with capecitabine in patients with metastatic breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Adriamycin-induced heart failure: mechanism and modulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Mitochondrial control of cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964209

Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006965107

Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006965107

Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006965107

Vardenafil: a novel type 5 phosphodiesterase inhibitor reduces myocardial infarct size following ischemia/reperfusion injury via opening of mitochondrial K(ATP) channels in rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006965107

Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006965107

Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006965107

Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006965107

Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006965107

Exisulind in combination with celecoxib modulates epidermal growth factor receptor, cyclooxygenase-2, and cyclin D1 against prostate carcinogenesis: in vivo evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006965107

Use of combined intracorporal injection and a phosphodiesterase-5 inhibitor therapy for men with a suboptimal response to sildenafil and/or vardenafil monotherapy after radical retropubic prostatectomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006965107

The efficacy of sildenafil citrate following radiation therapy for prostate cancer: temporal considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006965107

Analysis of the impact of androgen deprivation therapy on sildenafil citrate response following radiation therapy for prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006965107

Doxorubicin pretreatment sensitizes prostate cancer cell lines to TRAIL induced apoptosis which correlates with the loss of c-FLIP expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006965107

Reactive oxygen species mediate doxorubicin induced p53-independent apoptosis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20884855

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20884855

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1006965107

1 reference

31 July 2017

0 references

1 reference

31 July 2017

1 reference