BMP signaling in the human fetal ovary is developmentally regulated and promotes primordial germ cell apoptosis (Q34243004)

31 July 2017

title

BMP signaling in the human fetal ovary is developmentally regulated and promotes primordial germ cell apoptosis (English)

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31 July 2017

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Andrew J Childs

1

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author name string

Hazel L Kinnell

2

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31 July 2017

Craig S Collins

3

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31 July 2017

Kirsten Hogg

4

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31 July 2017

Rosemary A L Bayne

5

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31 July 2017

Samira J Green

6

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31 July 2017

Alan S McNeilly

7

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31 July 2017

Richard A Anderson

8

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31 July 2017

language of work or name

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1 August 2010

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31 July 2017

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31 July 2017

volume

28

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31 July 2017

issue

8

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31 July 2017

page(s)

1368-1378

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The primordial pool of follicles and nest breakdown in mammalian ovaries

31 July 2017

cites work

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The forkhead transcription factor FOXL2 is expressed in somatic cells of the human ovary prior to follicle formation.

6 July 2018

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Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes.

6 July 2018

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Production of offspring from a germline stem cell line derived from neonatal ovaries

6 July 2018

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Isolation of primordial germ cells from differentiating human embryonic stem cells

6 July 2018

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The role of oxygen availability in embryonic development and stem cell function

6 July 2018

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Conserved and divergent patterns of expression of DAZL, VASA and OCT4 in the germ cells of the human fetal ovary and testis

6 July 2018

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Retinoid signaling determines germ cell fate in mice

6 July 2018

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Retinoic acid regulates sex-specific timing of meiotic initiation in mice

6 July 2018

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Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors.

6 July 2018

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BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo

6 July 2018

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Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis

6 July 2018

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Germline stem cells and follicular renewal in the postnatal mammalian ovary

6 July 2018

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Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation

6 July 2018

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AMH induces mesonephric cell migration in XX gonads

6 July 2018

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Primordial germ cells in the mouse

6 July 2018

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The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival

6 July 2018

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Continuous loss of oocytes throughout meiotic prophase in the normal mouse ovary

6 July 2018

1 reference

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Msx2 and p21(CIP1/WAF1) mediate the proapoptotic effects of bone morphogenetic protein-4 on ventricular zone progenitor cells

6 July 2018

1 reference

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Formation of ovarian follicles during fetal development in sheep

6 July 2018

1 reference

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A preliminary report on the implication of RT-PCR detection of DAZ, RBMY1, USP9Y and Protamine-2 mRNA in testicular biopsy samples from azoospermic men

6 July 2018

1 reference

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Derivation in culture of primordial germ cells from cells of the mouse epiblast: phenotypic induction and growth control by Bmp4 signalling

6 July 2018

1 reference

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Msx-2 and p21 mediate the pro-apoptotic but not the anti-proliferative effects of BMP4 on cultured sympathetic neuroblasts

6 July 2018

1 reference

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Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Synergistic effects of different bone morphogenetic protein type I receptors on alkaline phosphatase induction

6 July 2018

1 reference

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How cells read TGF-beta signals

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Requirement of Bmp8b for the generation of primordial germ cells in the mouse

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Importin beta mediates nuclear translocation of Smad 3

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Bmp4 is required for the generation of primordial germ cells in the mouse embryo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Derivation of pluripotent stem cells from cultured human primordial germ cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Female mouse germ cells form synchronously dividing cysts.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Msx2 is a transcriptional regulator in the BMP4-mediated programmed cell death pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Bone morphogenetic proteins in development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Requirement for BMP signaling in interdigital apoptosis and scale formation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Clonal analysis of the origin of primordial germ cells in the mouse

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Growth factor regulation of mouse primordial germ cell development.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Stem cell factor and leukemia inhibitory factor promote primordial germ cell survival by suppressing programmed cell death (apoptosis)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Defining the window of germline genesis in vitro from murine embryonic stem cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

KIT ligand and bone morphogenetic protein signaling enhances human embryonic stem cell to germ-like cell differentiation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Prostaglandin E2 as a regulator of germ cells during ovarian development.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Steel factor controls primordial germ cell survival and motility from the time of their specification in the allantois, and provides a continuous niche throughout their migration.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Bmp7 regulates germ cell proliferation in mouse fetal gonads.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Expression of bone morphogenetic proteins 4 and 7 and their receptors IA, IB, and II in human ovaries from fetuses and adults.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Bone morphogenetic proteins induce germ cell differentiation from human embryonic stem cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

BMP signaling regulates PGC numbers and motility in organ culture.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Number of germ cells and somatic cells in human fetal ovaries during the first weeks after sex differentiation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Germ cell proliferation and apoptosis in the developing human ovary.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Differentiation and development of human female germ cells during prenatal gonadogenesis: an immunohistochemical study.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Derivation of human embryonic germ cells: an alternative source of pluripotent stem cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

GP130, the shared receptor for the LIF/IL6 cytokine family in the mouse, is not required for early germ cell differentiation, but is required cell-autonomously in oocytes for ovulation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Developmental expression of BMP4/ALK3/SMAD5 signaling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

A molecular programme for the specification of germ cell fate in mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Differentiation of mouse primordial germ cells into female or male germ cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Mouse ovarian germ cell cysts undergo programmed breakdown to form primordial follicles.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Bmp4 mediates apoptotic cell death in the developing chick eye.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Ectopic expression of Msx-2 in posterior limb bud mesoderm impairs limb morphogenesis while inducing BMP-4 expression, inhibiting cell proliferation, and promoting apoptosis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Adenovirus-mediated ectopic expression of Msx2 in even-numbered rhombomeres induces apoptotic elimination of cranial neural crest cells in ovo.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2964513

Retinoic acid is a potent growth activator of mouse primordial germ cells in vitro

28 October 2018

1 reference

12 December 2020

Functional requirement of gp130-mediated signaling for growth and survival of mouse primordial germ cells in vitro and derivation of embryonic germ (EG) cells

1 reference

12 December 2020

Subcellular distribution of importins correlates with germ cell maturation

1 reference

12 December 2020

Requirement ofBmp8bfor the Generation of Primordial Germ Cells in the Mouse

1 reference

12 December 2020

Identifiers

DOI

10.1002/STEM.440

1 reference

31 July 2017

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31 July 2017

1 reference