How cells read TGF-beta signals (Q29619993)

Europe PubMed Central

title

How cells read TGF-beta signals (English)

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type II transforming growth factor beta receptor binding

30 April 2017

main subject

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Gene Ontology release 2020-05-02

Massagué J

1

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30 April 2017

language of work or name

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30 April 2017

publication date

December 2000

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Nature Reviews Molecular Cell Biology

30 April 2017

published in

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30 April 2017

volume

1

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30 April 2017

issue

3

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30 April 2017

page(s)

169-78

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TGF-beta signal transduction

30 April 2017

cites work

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7 January 2021

Nodal signalling in vertebrate development.

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7 January 2021

Smads and early developmental signaling by the TGFbeta superfamily

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7 January 2021

TGFbeta signaling in growth control, cancer, and heritable disorders

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7 January 2021

Mechanism of activation of the TGF-beta receptor

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7 January 2021

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

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7 January 2021

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

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7 January 2021

TGF-beta family signal transduction in Drosophila development: from Mad to Smads.

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7 January 2021

The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation.

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7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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7 January 2021

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

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7 January 2021

Smad4 and FAST-1 in the assembly of activin-responsive factor

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7 January 2021

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

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7 January 2021

The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain

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7 January 2021

TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

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7 January 2021

Transcriptional control by the TGF-beta/Smad signaling system

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7 January 2021

The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors

1 reference

7 January 2021

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

1 reference

7 January 2021

Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha

1 reference

7 January 2021

Importin beta mediates nuclear translocation of Smad 3

1 reference

7 January 2021

Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4

1 reference

7 January 2021

Functional mapping of the MH1 DNA-binding domain of DPC4/SMAD4.

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7 January 2021

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

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7 January 2021

Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal

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7 January 2021

Identification of two Smad4 proteins in Xenopus. Their common and distinct properties.

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7 January 2021

Determinants of specificity in TGF-beta signal transduction.

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7 January 2021

Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily.

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7 January 2021

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

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7 January 2021

The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry

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7 January 2021

Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression

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7 January 2021

Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2

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7 January 2021

A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity

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7 January 2021

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.

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7 January 2021

Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

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7 January 2021

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

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7 January 2021

Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter

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7 January 2021

OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways

1 reference

7 January 2021

The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis

1 reference

7 January 2021

Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins

1 reference

7 January 2021

A transcriptional partner for MAD proteins in TGF-beta signalling

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7 January 2021

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

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7 January 2021

Expression of the PEBP2alphaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells

1 reference

7 January 2021

Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes

1 reference

7 January 2021

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter

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7 January 2021

Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.

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7 January 2021

Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways

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7 January 2021

A Smad transcriptional corepressor

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7 January 2021

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

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7 January 2021

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling

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7 January 2021

Distinctive gene expression patterns in human mammary epithelial cells and breast cancers

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7 January 2021

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

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7 January 2021

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination

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7 January 2021

Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling.

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7 January 2021

Smad2 role in mesoderm formation, left-right patterning and craniofacial development

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7 January 2021

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

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7 January 2021

Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression

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7 January 2021

ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

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7 January 2021

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development

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7 January 2021

TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

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7 January 2021

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

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7 January 2021

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

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7 January 2021

Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

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7 January 2021

Signaling inputs converge on nuclear effectors in TGF-beta signaling

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7 January 2021

Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs.

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7 January 2021

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7 January 2021

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

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7 January 2021

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

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7 January 2021

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

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7 January 2021

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

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7 January 2021

Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors.

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7 January 2021

Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.

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7 January 2021

Daughters against dpp modulates dpp organizing activity in Drosophila wing development

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7 January 2021

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

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7 January 2021

Evidence for a role of Smad6 in chick cardiac development.

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7 January 2021

Smad7 and Smad6 differentially modulate transforming growth factor beta -induced inhibition of embryonic lung morphogenesis

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7 January 2021

A role for smad6 in development and homeostasis of the cardiovascular system

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7 January 2021

Smad6 inhibits signalling by the TGF-beta superfamily.

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7 January 2021

Betaglycan presents ligand to the TGF beta signaling receptor.

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7 January 2021

Betaglycan binds inhibin and can mediate functional antagonism of activin signalling

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7 January 2021

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.

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7 January 2021

Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts

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7 January 2021

Thrombospondin-1 is a major activator of TGF-beta1 in vivo

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7 January 2021

Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm.

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7 January 2021

The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors

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7 January 2021

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

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7 January 2021

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

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7 January 2021

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

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7 January 2021

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

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7 January 2021

Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia.

1 reference

7 January 2021

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

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7 January 2021

Mixer, a homeobox gene required for endoderm development.

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7 January 2021

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

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7 January 2021

A structural basis for mutational inactivation of the tumour suppressor Smad4

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7 January 2021

Structural basis of Smad2 recognition by the Smad anchor for receptor activation

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7 January 2021

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

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7 January 2021

A human Mad protein acting as a BMP-regulated transcriptional activator

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7 January 2021

BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners

1 reference

7 January 2021

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