Therapeutic modulation of transcription factor activity (Q34243153)

31 July 2017

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title

Therapeutic modulation of transcription factor activity (English)

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31 July 2017

Emery JG

1

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PubMed ID

11339974

31 July 2017

Ohlstein EH

series ordinal

2

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PubMed ID

11339974

31 July 2017

Jaye M

series ordinal

3

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31 July 2017

1 May 2001

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Trends in Pharmacological Sciences

31 July 2017

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31 July 2017

22

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31 July 2017

5

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31 July 2017

233-240

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TRANSFAC: an integrated system for gene expression regulation

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Transport-Dependent Proteolysis of SREBP

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Four cholesterol-sensing proteins.

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Nuclear hormone receptor coregulators in action: diversity for shared tasks

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Orphan nuclear receptors: shifting endocrinology into reverse

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

The RXR heterodimers and orphan receptors

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Increasing the complexity of coactivation in nuclear receptor signaling

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Transcriptional repression by nuclear hormone receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Molecular basis of agonism and antagonism in the oestrogen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Comparative analyses of mechanistic differences among antiestrogens

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

An issue of tissues: divining the split personalities of selective estrogen receptor modulators

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Molecular mechanism of a cross-talk between oestrogen and growth factor signalling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Regulation of lipid and lipoprotein metabolism by PPAR activators

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Peroxisome proliferator-activated receptors: insight into multiple cellular functions

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: a randomized controlled trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Activation of PPARdelta alters lipid metabolism in db/db mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

PPAR delta functions as a prostacyclin receptor in blastocyst implantation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

The Homeodomain Resource: sequences, structures and genomic information

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Homeodomain protein IDX-1: a master regulator of pancreas development and insulin gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

The nuclear localization signal (NLS) of PDX-1 is part of the homeodomain and represents a novel type of NLS.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Identification of a nuclear localization signal, RRMKWKK, in the homeodomain transcription factor PDX-1

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sen

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Transforming growth factor beta induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Transcription factors of the NFAT family: regulation and function

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Manipulating immune responses with immunosuppressive agents that target NFAT.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

FK506, an immunosuppressant targeting calcineurin function

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

NF-kappa B: ten years after

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

The NF-kappa B and I kappa B proteins: new discoveries and insights

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Structure, regulation and function of NF-kappa B

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

IKK1-deficient mice exhibit abnormal development of skin and skeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Limb and skin abnormalities in mice lacking IKKalpha

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Sulindac inhibits activation of the NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

Evaluation of the effectiveness of DNA-binding drugs to inhibit transcription using the c-fos serum response element as a target

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901661-8

7 January 2021

10.1016/S0165-6147(00)01661-8

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11339974